A. Villechenous

Thrilled to join Prof. Aidan McDonald’s group at @tcddublin.bsky.social as a postdoc!🤩👨🏾‍🔬🤩
Excited to contribute to Bioinspired Catalysis, exploring molecular catalysts to address global challenges. 🧪🌍
Ready for this new adventure! 🤓🤜🏾🤛🏾 #Organometallic #Catalysis #PostdocLife

Molecular Design Principles for Photoactive Transition Metal Complexes: A Guide for “Photo-Motivated” Chemists Luminescence and photochemistry involve electronically excited states that are inherently unstable and therefore spontaneously decay to electronic ground states, in most cases by nonradiative energy release that generates heat. This energy dissipation can occur on a time scale of 100 fs (∼10–13 s) and usually needs to be slowed down to at least the nanosecond (∼10–9 s) time scale for luminescence and intermolecular photochemistry to occur. This is a challenging task with many different factors to consider. An alternative emerging strategy is to target dissociative excited states that lead to metal–ligand bond homolysis on the subnanosecond time scale to access synthetically useful radicals. Based on a thorough review at the most recent advances in the field, this article aims to provide a concise guide to obtaining luminescent and photochemically useful coordination compounds with d-block elements. We hope to encourage “photo-motivated” chemists who have been reluctant to apply their synthetic and other knowledge to photophysics and photochemistry, and we intend to stimulate new approaches to the synthetic control of excited state behavior.

A simple guide to the design of metal complexes in luminescence and photoredox catalysis.

With Giacomo Morselli and Christian Reber in JACS @jacs.acspublications.org

pubs.acs.org/doi/10.1021/...

🫣😮🤯

Manipulating metal–ligand binding in allosteric coordination complexes through ring strain The weak-link approach (WLA) to organometallic complexes offers a powerful method to create allosteric shape-shifting coordination complexes. However, chemically tuning the metal–ligand interactions…

Check out this article from Chad Mirkin and colleagues at @iinanonu.bsky.social

'Manipulating metal–ligand binding in allosteric coordination complexes through ring strain'

#OpenAccess 🔓

Catalysis in the Excited State: Bringing Innate Transition Metal Photochemistry into Play Transition metal catalysis is an indispensable tool for organic synthesis that has been harnessed, modulated, and perfected for many decades by careful selection of metal centers and ligands, giving r...

If you wonder about how to harness innate excited-state reactivity in TM photocatalysis to design new synthetic methods, you can find some guidelines and a rationalization attending to orbitals in this Perspective, just published in
ACSCatalysis @acs.org:
pubs.acs.org/doi/10.1021/...
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Discovery of Phototoxic Metal Complexes with Antibacterial Properties via a Combinatorial Approach | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Vilar and co-workers @InorgChem #iridium #antibacterial #combinatorial #S_aureus #MRSA #phototoxic #ROS #permeability #bactericidal

Happy to share some of the results coming from my PhD with SCK CEN and @gassergroup.bsky.social accepted in @chemicalscience.rsc.org ! This work focuses on radiolabelling methods to attach Re-188 to a Nanobody for use in the targeted radionuclide therapy of cancer ☢️

🚀 Exciting news! Our paper “Copper(II) cyclopeptides with high ROS-mediated cytotoxicity” has been accepted in Bioconjugate Chemistry! @pubs.acs.org 🎉

More details soon!

#Metallodrugs #ROS #BioconjugateChem #MetalPeptides #ChemSky