Danve Castroverde

Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR - Nature SUMM2, a coiled-coil NLR, promotes the assembly of higher-order resistosome clusters to initiate cell death in plants.

To activate plant immunity, NLR receptors such as SUMM2 form resistosome complexes, which act as Ca2+-permeable plasma-membrane channels. Work @nature shows how SUMM2 and its associates assemble into even higher-order clusters to initiate cell death.
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A sorghum pangenome reference improves global crop trait discovery - Nature A pangenome reference for the phenotypically diverse crop sorghum aims to help accelerate future efforts to breed crops that are better adapted to changing environments.

A sorghum pangenome reference improves global crop trait discovery

www.nature.com/articles/s41...

Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR - Nature SUMM2, a coiled-coil NLR, promotes the assembly of higher-order resistosome clusters to initiate cell death in plants.

Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR

www.nature.com/articles/s41...

Gene regulatory networks: from correlative models to causal explanations - Nature Reviews Genetics In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without compromising explanatory power.

Gene regulatory networks: from correlative models to causal explanations

www.nature.com/articles/s41...

NAD+ hydrolysis catalyzed by SelO is required for mitochondrial homeostasis SelO, a conserved mitochondrial enzyme, hydrolyzes NAD+ in response to elevated matrix pH, directly regulating lipid metabolism and safeguarding mitochondrial homeostasis.

Now online! NAD+ hydrolysis catalyzed by SelO is required for mitochondrial homeostasis

Arabidopsis acclimation to daily environmental fluctuations converts a defense response regulator into a susceptibility factor toward Sclerotinia Acclimation enables plants to adjust to immediate environmental fluctuations and is therefore key to the resilience of plant disease resistance in a time of climate change. Here, we report on the ac.....

Arabidopsis acclimation to daily environmental fluctuations converts a defense response regulator into a susceptibility factor toward Sclerotinia

nph.onlinelibrary.wiley.com/doi/10.1111/...

CUL3LRB E3 ubiquitin ligases control thermosensory growth in Arabidopsis by differentially regulating HY5 and PIF4 protein stability LRBs potentiate thermosensory growth by inhibiting HY5 activity while promoting PIF4 function.

Delighted to share new research from Plant_EnSiGn Lab_IISER Kolkata, India

CUL3LRB E3 ubiquitin ligases control thermosensory growth in Arabidopsis by differentially regulating HY5 and PIF4 protein stability | Science Advances www.science.org/doi/10.1126/...

The brassinosteroid receptor BRL3 triggers acclimation to elevated temperature from phloem companion cells in Arabidopsis Phloem companion cell-enriched BRASSINOSTEROID-INSENSITIVE 1-LIKE3 controls Arabidopsis temperature adaptation.

The brassinosteroid receptor BRL3 triggers acclimation to elevated temperature from phloem companion cells in Arabidopsis

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An H3K4me3 reader recruits the positive transcription elongation factor B complex to facilitate transcription elongation in Arabidopsis The molecular mechanisms by which H3K4me3 promotes transcription elongation remain largely unclear. Yu et al. show that the H3K4me3 reader RGSA1 recruits the positive transcription elongation factor B...

An H3K4me3 reader recruits the positive transcription elongation factor B complex to facilitate transcription elongation in Arabidopsis

www.cell.com/developmenta...

Model of the site-specific coumarin secretion coordinately driven by NRT1/PTR FAMILY 7.2 and PDR9.

The Arabidopsis NPF7.2 mediates #coumarin uptake for root iron acquisition

📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
by Watanabe et al.

#PlantScience

odel of the involvement of Copper transporter4 in CuTI in Arabidopsis. C

The COPTs‒ATX1 axis is upstream of the bHLH107‒ACS8 module for copper-triggered immunity.

📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
by Xia et al.

#PlantScience

Image was created using the software BioGDP.com (Jiang et al., 2025).

The emerging role of kinase fusion proteins in cereal immunity Lehti-Shiu, M. D. & Shiu, S. H. Diversity, classification and function of the plant protein kinase superfamily. Philos. Trans. R. Soc. Lond. B Biol. Sci. 367, 2619–2639 (2012). Jamieson, P. A., Shan, L. & He, P. Plant cell surface molecular cypher: receptor-like proteins and their roles in immunity and development. Plant Sci. 274, 242–251 (2018). DeFalco, T. A. & Zipfel, C. Molecular mechanisms of early plant pattern-triggered immune signaling. Mol. Cell 81, 3449–3467 (2021). Yu, X., Feng, B., He, P. & Shan, L. From chaos to harmony: responses and signaling upon microbial pattern recognition. Annu. Rev. Phytopathol. 55, 109–137 (2017). Kourelis, J. & van der Hoorn, R. A. L. Defended to the nines: 25 years of resistance gene cloning identifies nine mechanisms for R protein function. Plant Cell. 30, 285–299 (2018). Liang, X. et al. A Phytophthora capsici RXLR effector targets and inhibits the central immune kinases to suppress plant immunity. New Phytol. 232, 264–278 (2021). Wan, C. et al. A serine-rich effector from the stripe rust pathogen targets a Raf-like kinase to suppress host immunity. Plant Physiol. 190, 762–778 (2022). Chen, R., Gajendiran, K. & Wulff, B. B. H. R we there yet? Advances in cloning resistance genes for...

The emerging role of kinase fusion proteins in cereal immunity
->Nature | More on "Kinase fusion proteins cereal immunity" at BigEarthData.ai

In Vivo Monitoring of Energy Metabolism with Genetically Encoded Fluorescent Biosensors All organisms fuel and build themselves through their energy metabolism. While classic biochemistry conceptualizes the fluxes of energy and matter, our understanding of how energy metabolism works in ...

Freshly online 🗞️
In Vivo Monitoring of Energy Metabolism with Genetically Encoded Fluorescent Biosensors 🌱🔋🌈🔬

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@morganlab-saarland.bsky.social
@uni-muenster.de
doi.org/10.1146/annu...

A dual role of Arabidopsis PAL nuclear localization in fine tuning flavonoid biosynthesis PAL’s dual localization links metabolism with transcription, revealing feedback that fine-tunes phenylpropanoid regulation.

Interesting paper: Metabolic enzyme PAL can go into the nucleus in response to high product build up and sequester an activating TF of the pathway, thus acting as a feedback inhibition loop.

From: www.science.org/doi/full/10....
#PlantScience

An unconventional Rubisco small subunit underpins the CO2-concentrating organelle in land plants In many algae, photosynthesis is boosted by biophysical CO2-concentrating mechanisms, which pack the CO2-fixing enzyme Rubisco into liquid-like organelles called pyrenoids. Engineering C3 crops with a...

An unconventional Rubisco small subunit underpins the CO2-concentrating organelle in land plants

www.science.org/doi/10.1126/...

Nanodomain-localized formin gates symbiotic microbial entry in legume and solanaceous plants Colonization of plant roots by symbionts requires substantial morphodynamic reorganization. Examples are actin-scaffolded microcompartments called infection pockets formed during root nodule symbiosis...

Nanodomain-localized formin gates symbiotic microbial entry in legume and solanaceous plants

www.science.org/doi/10.1126/...

Decoding Arabidopsis growth-defense trade-offs through ADR1-associated transcriptional networks Using DANGEROUS MIX autoimmune plants with constitutively active NLRs, Hu et al. dissect growth-defense trade-offs. Two major transcriptional modules, representing growth and defense, show a strong in...

Decoding Arabidopsis growth-defense trade-offs through ADR1-associated transcriptional networks

www.cell.com/cell-reports...

Genome modelling and design across all domains of life with Evo 2 - Nature Evo 2 is an artificial intelligence-based biological foundation model trained on 9 trillion DNA base pairs spanning all domains of life that predicts functional properties from genomic sequences and p...

First released one year ago, Evo 2 predicts variant effects & generates functional DNA across all domains of life, from bacteria to humans, from a single set of weights, with no fine-tuning required.

www.nature.com/articles/s41...

A prominent role of the circadian proteins PRR5 and PRR7 in governing Arabidopsis immunity The core clock components PSEUDO-RESPONSE REGULATOR 5 (PRR5) and PRR7 antagonized function of the complex of NONEXPRESSER OF PATHOGENESIS-RELATED GENES 1 with the transcription factor TGA3 to directl....

A prominent role of the circadian proteins PRR5 and PRR7 in governing Arabidopsis immunity

onlinelibrary.wiley.com/doi/10.1111/...

The HIRA-interacting histone chaperone CABIN1 negatively regulates plant immunity mediated by immune receptor gene SNC1 The HIRA-interacting histone chaperone protein CABIN1 negatively regulates plant immunity via modulating expression of an intracellular immune receptor gen

The HIRA-interacting histone chaperone CABIN1 negatively regulates plant immunity mediated by immune receptor gene SNC1

academic.oup.com/plphys/advan...

The trans‐Golgi network adaptor protein 4 complex contributes to basal defense and immunity mediated through plasma membrane and intracellular immune receptors The trans-Golgi network adaptor protein 4 (AP4) complex, which mediates protein sorting to the plant vacuole, is essential for broad immune responses including basal defense as well as pattern- and e...

The trans-Golgi network adaptor protein 4 complex contributes to basal defense and immunity mediated through plasma membrane and intracellular immune receptors

onlinelibrary.wiley.com/doi/10.1111/...

Immune activation reprograms growth mRNA stability to shape plant growth-defense trade-offs Zhou et al. show that plant immunity naturally represses growth by promoting PTBP3-dependent degradation of pyrimidine-rich, Y-motif-containing growth mRNAs. Notably, artificial antagonism of this pos...

Immune activation reprograms growth mRNA stability to shape plant growth-defense trade-offs

www.cell.com/cell-host-mi...

Dynamic regulation of protein homeostasis underlies thermopriming-mediated acquired thermotolerance in Arabidopsis Summary Thermopriming (pre-exposure to sublethal high temperature) restores proteostasis by temporally activating the HSFA1-dependent heat shock response, the unfolded protein response, and autophagy,...

Dynamic regulation of protein homeostasis underlies thermopriming-mediated acquired thermotolerance in Arabidopsis

www.cell.com/plant-commun...

OsWRI1a coordinates systemic growth responses to nitrogen availability in rice Nitrogen (N) deficiency–induced increases in the root-to-shoot biomass ratio in plants are adaptive in nature but suboptimal for agriculture. Understanding the regulatory mechanisms governing this dev...

OsWRI1a coordinates systemic growth responses to nitrogen availability in rice

www.science.org/doi/10.1126/...

Viral action on the auxin signaling repressor IAA16 reveals a conserved negative regulator of plant growth and immunity Chen et al. report that viral proteins subvert both plant growth and immunity by stabilizing the master negative regulator IAA16 via disrupting the recruitment of the E3 ubiquitin ligase ATL52. IAA16 ...

Viral action on the auxin signaling repressor IAA16 reveals a conserved negative regulator of plant growth and immunity

www.cell.com/cell-reports...

Immune activation suppresses reproductive growth in Arabidopsis through cytokinin signaling Johnston et al. report that defense hormones suppress cytokinin signaling, causing yield penalties. Restoring cytokinin in autoimmune plants relieves reproductive defects, confers broad pathogen resis...

Immune activation suppresses reproductive growth in Arabidopsis through cytokinin signaling

www.cell.com/current-biol...

Calcium signaling in plants: Universal and unique paradigms This review discusses how recent discoveries are transforming our understanding of the function of Ca2+ in plants and its signaling pathways.

This issue features a Review on plant calcium signaling
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Rewiring an E3 ligase enhances cold resilience and phosphate use in maize - Nature The E3 ubiquitin ligase NLA postively regulates cold tolerance and negatively regulates phosphate uptake in maize, and a genetically engineered variant of this enzyme leads to improved cold ...

Rewiring an E3 ligase enhances cold resilience and phosphate use in maize

www.nature.com/articles/s41...

Editing strigolactone hormone receptor for robust antiviral silencing in rice Precise genome editing of the rice strigolactone receptor DWARF14 confers robust, transgene-free antiviral resistance by blocking viral suppression of endogenous RNA silencing, offering a promising st...

Editing strigolactone hormone receptor for robust antiviral silencing in rice

www.cell.com/cell/fulltex...