Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
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#MolBio 🧪
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Congratulations!
Thank you, Ahmad!
*tough
Excited to share this preprint from my lab. We report a potent and site-specific inhibition of translation initiation by 2’O methylation.
It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology
New Wall Street Journal about Northwestern and the funding freeze.
[Gift link]
www.wsj.com/us-news/educ...
1/n
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@thedailynu.bsky.social Northwestern is still supporting our research despite not receiving any $ from active and new fundable grants. Definitely unsustainable and anxieties are piling up..
Funding freeze at Northwestern from Emma Mairson at
grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis.
Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.
I helped explain to the Chicago Tribune the enourmous and irrational damage the NIH funding freeze is causing at Northwestern. “You’re at risk of losing an entire next generation of scientists" "it’s terrifying; it’s completely senseless." www.chicagotribune.com/2025/06/07/w...
Keep in mind: these are AWARDED grants, with Notice of Awards. The federal government is not honoring existing contracts with this university, refusing to reimburse for costs charge on awarded grants.
Professors and researchers at Chicago-area universities said federal funding cuts are leaving research projects unfinished.
Julius Lucks, a chemical engineering professor at Northwestern, speaks on if another sector could fund university research.
to.wttw.com/3Ygl3T8
Ready for the next RNA session in @asbmb.bsky.social meeting. We start soon...
Happened to me too
In the midst of everything it feels particularly appropriate to highlight all the amazing #RNA research taking place at #NIH!
Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!
It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...
Letter from the NIH indicating that my grant has been terminated (though it seems we can keep the remaining funds for this year?)
Finally got the notice. Very sad day for the MOSAIC program that supported some of the most amazing scientists I know, as well as some of the awesome people on my lab.
So proud of this incredible work from @g-agarwal.bsky.social from our group with help from many fantastic folks in our lab and inspiring collaborators, including @kharaslab.bsky.social, Alex Bick, @yashpershad.bsky.social, and many others! Please check out Gaurav's awesome 🧵👇👇
Small proteins can be more complex than they look!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
We were delighted to have @king5news.com.web.brid.gy visit us in the Termini Lab to discuss how NIH funding cuts could affect cancer research:
m.youtube.com/watch?v=Szo9...
We NEED indirect costs to provide funding needed complete research studies that will lead to life saving discoveries.
NIH is the best investment there is.
www.forbes.com/sites/michae...
The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. Read our statement: https://buff.ly/4gRXNB8
Online Now: The integrated stress response regulates 18S nonfunctional rRNA decay in mammals
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Interested in RNA biology, cancer or vascular research? I have a position open for either a research assistant or a new postdoc to start expanding the fast-growing research area of cardio-oncology! Apply here: jobs.ncl.ac.uk/job/Newcastl...
Happy to have informal chats! Please share 🧬.
