Linda Kim

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy - Nature Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari...

Excited to share our latest Nature publication, headed by the Pacold lab. Our experimental compound shows great promise as a novel, mechanistic treatment for a pediatric disorder that can prove fatal. It also highlights the therapeutic relevance of the cerebellum. #neuroskyence tinyurl.com/yh9736m9

The molecular and cellular underpinnings of human brain lateralization Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization

🔗 doi.org/10.1101/2025...

🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇

#neuroskyence

Key players in brain aging: New research identifies age-related damage on a cellular level New research identifies age-related damage on a cellular level

In case you missed it, we recently published one of the largest studies of the aging brain.

It reveals new insights into how the brain ages including possible connections between diet, inflammation, and brain health.

🧠📈 More at alleninstitute.org/news/key-pla...

#studyBRAIN #BrainAwarenessWeek

What are the cells that make up our brains? YouTube video by Allen Institute

To understand the brain, we must first understand its parts — the cells. 🧠📈

Together with our partners across the country, we're cataloging cell types in the brain with the most detailed map of the motor cortex ever.

🎬 www.youtube.com/watch?v=ylt2...

#BrainWeek #BrainAwarenessWeek #studyBRAIN

Between Nothing and Everything: Phenomenology in Movement Disorders Click on the article title to read more.

Viewpoint with Mark Edwards debating the relevance of clinical phenomenology in movement disorders!

doi.org/10.1002/mds....

New in 𝐶𝑒𝑙𝑙

𝗣𝗮𝘆(𝗹𝗼𝗮𝗱) 𝗧𝗵𝗿𝗼𝘂𝗴𝗵 𝘁𝗵𝗲 𝗡𝗼𝘀𝗲

Intranasal 𝐿𝑎𝑐𝑡𝑜𝑏𝑎𝑐𝑖𝑙𝑙𝑢𝑠 𝑝𝑙𝑎𝑛𝑡𝑎𝑟𝑢𝑚 (Lp) engineered to release drugs in the olfactory epithelium, facilitating their transport to the brain

intranasal Lp-secreted leptin (appetite-regulating hormone) reduced obesity in mice

www.cell.com/cell/fulltex...

US drug agency approves potent painkiller — the first non-opioid in decades The FDA’s nod for suzetrigine bolsters confidence in the pharmaceutical industry’s strategy to target sodium channels.

FDA approves new pain killer- First non-opioid analgesic in decades targets sodium channels.

#painresearch
#physio
#neuroskyence
🛟🧪

www.nature.com/articles/d41...

Varying the intensity of vagal nerve stimulation differentially activates NTS and NTS TH neuron c-Fos expression.

VNS at mid-intensity decreased anxiety-like behavior without affecting reward or aversion in rats. This intensity also increased c-Fos expression in noradrenergic NTS neurons while reducing it in the LC. #neuroskyence 🩺
Butler et al. Brain Stim
www.sciencedirect.com/science/arti...

I think it is obvious we need to pay 'more' attention to resilience factors, and invest 'more' in understanding what is vulnerable. How can we use 'intrinsic characteristics' of cells to our advantage? To use a Star Wars analogy, 'use the force Luke.' Let us move – a fortiori – with stronger reason.

Guess what? There are early motor signs even in Alzheimer's and Lewy Body Disease. Are there early motor features that predict pathology or co-pathology? Spoiler alert: Look at the face. Daniel Oh and colleagues collected the information and collected brains to teach us.

Mysterious Blobs in Cells Are Changing the Way We Understand Life Tiny specks called biomolecular condensates are leading to a new understanding of the cell

Mysterious Blobs Found inside Cells Are Rewriting the Story of How Life Works

Tiny specks called biomolecular condensates are leading to a new understanding of the cell

www.scientificamerican.com/article/myst...

🚨 New Research! 🚨

Our new preprint is live on BioRxiv. Check out the link below if you're interested in learning more about how spinal circuits modulate breathing!

www.biorxiv.org/content/10.1...

Newly characterized striatal circuits add twist to ‘go/no-go’ model of movement control The two novel pathways control dopamine release in opposing ways and may link motivation and mood to action, a new study shows.

The ‘go’ and ‘no-go’ pathways in the basal ganglia are not the only pathways that control movement, as a new study reveals two additional circuits that modulate dopamine and movement.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/basal-gangli...

Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice Age-related neurodegenerative diseases involve reduced cell numbers and impaired behavioral capacity. Neurodegeneration and behavioral deficits also occur during aging, and notably in the absence of d...

New from @sarahdonofrio.bsky.social: Aging leads to patterned Purkinje cell loss in the cerebellum, seen in both mice and humans. More insights into how aging shapes neuronal vulnerability here: www.biorxiv.org/content/10.1...
#neuroskyence

How important are your #postdoc years in the likelihood of you staying & succeeding in #academia?

In our newly published paper in @pnas.org, "Postdoc Publications and Citations Link to Academic Retention and Faculty Success," we study the journey of #CareerSuccess of ~45,000 #postdocs.

🧵1/7

Dynamical constraints on neural population activity - Nature Neuroscience Oby, Degenhart, Grigsby and colleagues used a brain–computer interface to challenge monkeys to override their natural time courses of neural activity. They found the time courses to be highly robust, ...

Nature Neuroscience

Dynamical constraints on neural population activity

www.nature.com/articles/s41...

Tiny Sea Creatures Caught 'Talking' to Their Colony Mates In a discovery that challenges our understanding of social behavior, researchers have found that tiny single-celled organisms can coordinate their actions

New study demonstrates that tiny one-celled sea creatures use the same type of molecular machinery that
#neurons and muscle cells use to communicate. Could be a pathway to advance #AI and #robotics? scienceblog.com/553045/tiny-... #neuroscience

Huge congrats to @sarahdonofrio.bsky.social for her beautiful science communication piece, highlighted in Nature Features and Opinion! Dive into the fascinating story of how a neuroscientist unraveled his own long COVID mystery. www.youcanknowthings.com/how-one-neur.... #neuroskyence

The unbearable slowness of being: Why do we live at 10 bits/s? Zheng and Meister write about the paradoxical slowness of human behavior. Although our senses gather data at 109 bits/s, our overall information throughput is only 10 bits/s. This stark contrast touches on many fundamental aspects of brain function.

Lots of good discussion on this compelling new paper this week:
www.cell.com/neuron/abstr...
I'd like to offer my $0.02 along with some historical background that the article didn't give. 1/ #Neuroskyence #PsychSciSky

really great thread by Blake. Each neuron in an artificial neural network (ANN) isn't supposed to accurately model a neuron in the brain.
Instead, ANNs are good models of computation (through dynamics/manifolds) based on the collective activity of simpler "functions" (i.e., the neurons)

A neurocognitive pathway for engineering artificial touch Neurocognitive congruence is key to designing artificial touch that best integrates with human perception and action.

Very proud to share a new review (more like a long perspective), just out in Science Advances: rebrand.ly/mdbi8q8. Ilana Nisky and Tamar @cambridgeuni.bsky.social joined heads (brains) to reimagine how to make the most out of artificial haptic interfaces. A thread (1/8)

Final first-author paper from my postdoc w/ the brilliant @sylvainbaillet.bsky.social + crew!

We find converging evidence for a pathway b/w norepinephrine ➡️ cortical alpha rhythms ➡️ cognitive dysfunction in #Parkinson's disease

academic.oup.com/brain/advanc...

🧵👇

(1/n)

How neurons work together: A fractal approach to brain efficiency Brains balance individual neuron activity and scalable teamwork using a fractal hierarchy, optimizing efficiency and adaptability. This universal principle, found across species, enables resilience and rapid adaptation.

Brains balance individual neuron activity and scalable teamwork using a fractal hierarchy, optimizing efficiency and adaptability. This universal principle, found across species, enables resilience and rapid adaptation. #Neuroscience #BrainEfficiency #FractalApproach #Neurons #BrainResearch

Multi-timescale neural dynamics for multisensory integration - Nature Reviews Neuroscience How the brain routinely processes information from different sensory modalities during everyday tasks is not well understood. In this Perspective, Engel and Senkowski propose how oscillatory neural me...

Multi-timescale neural dynamics for multisensory integration
www.nature.com/articles/s41...
#neuroscience

I'm excited about this new analysis approach because we can now estimate when changes in strategy, goal choice, conflict etc. occur in open state spaces. Providing metrics for studies with patients & sec-sec metrics for upcoming fMRI data and existing iEEG data with Sea Hero Quest
#neuroskyence

Our paper on MouseGoggles - an open-source mini VR headset for mice - just came out! Really excited about finally integrating eye-tracking into the headset. Nice working with you @hongyuchang.bsky.social!
www.nature.com/articles/s41...
github.com/sn-lab/Mouse...
#neuroskyence

Since I need a first bsky post, here's a rehash of @nickhedger.bsky.social's thread announcing our preprint with Kendrick Kay & Thomas Naselaris. TLDR; High-level visual cortex is tiled with maps 'multiplexing' vision and touch. tinyurl.com/seesoma 🧵 1/n

Canadian Ph.D. student, Sam Mestern, wins first MapMySpikes challenge The Allen Institute for Brain Science's MapMySpikes challenge aimed to address a key challenge in neuroscience by making connections between cells' electrical and molecular properties.

Congrats to Sam Mestern, Ph.D. student at @westernu.bsky.social, for winning the MapMySpikes challenge! His tool, PatchOTDA, excelled in mapping electrophysiological data to molecular properties. 🧠📈

More on his tool and the MapMySpikes challenge: alleninstitute.org/news/canadia...

Thank you for the list! I would love to be added as well.