Arkadi Mazin @ Lifespan.io

Producing Thymic Factors in the Liver Rejuvenates Immunity A new study proposes a novel approach to fighting immune system decline caused by thymic involution: making the liver produce proteins that support T cell development and function [1]. Bringing back t...

I'm keeping a close eye on everything related to immunosenescence - I think it's a huge driver of aging and a likely bottleneck on the way to max lifespan extension. No wonder this study caught my attention:

www.lifespan.io/news/produci...

DNA Methylation Patterns Trace Blood Aging Dynamics Scientists have created a new, highly effective method of tracing blood cells’ lineage. This can improve our understanding of clonal hematopoiesis and its impact on an aging organism [1]. Hostile take...

Here's some cool research for you.

www.lifespan.io/news/dna-met...

Playing the Long Game Towards Radical Life Extension For most of the history of human civilization, humanity expanded at an astonishing pace: faster than exponential, nearly hyperbolic. This trend was famously described in a 1960 paper by Heinz von Foer...

My little pet project - op-eds by prominent geroscientists - just got a big boost with a fascinating piece by Peter Fedichev, CEO of Gero. If you are a renowned expert and want to join the conversation, or if you know one, please DM me. The field needs debate! www.lifespan.io/news/playing...

I'm sure it's all merit-based.

I know what Agent Orange is, but for a second, my brain thought it was a designation for Trump.

Undocumented immigrants' payments into Social Security detailed in report Undocumented residents paid £25.7 billion into Social Security funds and $6 billion into Medicare in 2022.

Who said all those numbers are collecting Social Security? Those numbers can be used for tax fraud, but it's far smaller sums than what undocumented immigrants pay to Social Security without receiving benefits. Getting rid of those numbers would COST, not save money.
www.newsweek.com/undocumented...

Mitochondrial Damage May Drive Type 2 Diabetes | Lifespan.io A new study suggests that damaged mitochondria activate the integrated stress response, which causes pancreatic β-cells, as well as liver and fat cells, to lose their identity and malfunction [1]. Blo...

New research led by Scott A. Soleimanpour, M.D. explores how mitochondrial dysfunction impacts type II diabetes—potentially paving the way for new treatment strategies and aging therapies.

www.lifespan.io/news/mitocho...
By: @arkadimazin.bsky.social

#longevity #health #diabetes

Correct me if I'm wrong, but this sounds like direct evidence for the genocide case in ICJ - POTUS himself (with the Israeli PM by his side) saying that Gaza has been reduced to rubble and is unlivable.

Do you dispute the figures?

I see that a lot of people here are attacking the messenger. Those numbers are probably real, and CNN has a duty to report them. Stop behaving like MAGA. Our advantage should be in being able to confront the reality.

New Drug Eliminates Breast Cancer in a Single Dose Researchers have discovered a small molecule that effectively kills cancer cells in the most prevalent type of breast cancer. The new […]

Good news!

www.lifespan.io/news/new-dru...

The Battle for Long Life Has Been Accomplished: What’s Next? How long can people live? This is not just a foundational question in science. The answer has important public policy implications and is of interest to […]

This is, hopefully, just the beginning of the op-ed project I’ve been working on. We want to give leading voices in the field a platform to share their views and spark discussion. If that’s you, and you’ve got something to say - DM me!
www.lifespan.io/news/the-bat...

Well, I guess California and other Blue States should just stop sending money to the federal budget.

Precision Targeting of Senescent Cells | Lifespan.io In a journal called Small, researchers have described a new targeting mechanism for delivering senolytic compounds where they need to go. Finding […]

Removing harmful senescent cells while sparing healthy cells = improve health.

Scientists are uncovering ways to precisely target these 'zombie cells,' paving the way for safer, more effective anti-aging therapies.

www.lifespan.io/news/precisi...
By: Josh Conway

#longevity

This might actually backfire for him.

An obvious choice would be Canada... Oh, wait...

Drinking and Dying: Alcohol as a Risk Factor for Cancer A new advisory by the US Surgeon General highlights a topic that – as the document itself notes – has been flying mostly under the public’s radar: the relationship between alcohol consumption and canc...

Everything in moderation... right?

When it comes to alcohol, it may not be that simple. Discover what new research and experts are saying about the link between drinking and cancer risk:

www.lifespan.io/news/drinkin...
By: @ArkadyMazin

#longevity #alcohol #cancerawareness

With its current government and public opinion, Israel has to be pushed hard towards the deal. The world must step in and eliminate this power imbalance. Technically, the two-state solution is achievable, but currently, there are zero incentives for Israel to go there.

There cannot be a territorial compromise except for minor and equal exchanges. I mean, I won't mind if Palestinians AGREE to a compromise, but they don't have to. This is fundamentally an oppressor vs the oppressed situation, so there's no equality, even if the latter is sometimes wrong.

Peter Diamandis: “Stay Healthy, Anti-Aging Tech is Coming” To many people, Peter Diamandis needs no introduction, and to the rest, it’s going to be a long one. To put it as concisely as possible, Peter is […]

Here's another highlight from 2024. I'm not going to lie, I've received a lot of compliments for this one 😜

www.lifespan.io/news/peter-d...

The Accords meant peace based on the current international law, which prohibits land acquisition by force (see UN SC resolution 242). This is why Egypt (and later Jordan) got ALL their land back in exchange for peace. Not sure about accountability, care to elaborate?

"Carter's flip from peace broker to contentious critic is odd, innit?" - not really. Israel pissed all over its obligation in the Framework for Peace in the Middle East agreement (part of the Camp David Accords) to solve the Palestinian problem.

I Dined with Bryan Johnson and Didn’t Die | Lifespan.io Anxious about being late and distrustful of LA’s afternoon traffic, I got to my destination quite a few minutes early and found myself in a quiet middle-class neighborhood. The house I was looking for...

Since I'm new here, posting some of my 2024 articles sounds like a good idea. Let's start with this one. Not sure how popular Bryan is on BlueSky, though 😀. But his views are worth considering if you ask me.
www.lifespan.io/news/i-dined...

The Best Talks From Longevity Summit 2024 | Lifespan.io Earlier this month, for the third year in a row, the famed Buck Institute for Research on Aging hosted the Longevity Summit. This two-day event was organized by Longevity Global, a community of longev...

In case you were looking for a longevity-related long read for the holidays, here's my latest:

www.lifespan.io/news/best-ta...

Why Research Teams Should Email XPRIZE Healthspan Now With the deadline for submissions just around the corner, Jamie Justice, Executive Director of XPRIZE HealthSpan, explains to researchers still on […]

Seriously though, you should :)
www.lifespan.io/news/why-res...

Announcing Vitalist Bay, a Pop-Up City in the Bay Area A unique project is set to go live next spring in the Bay Area. Organized by the Vitalism Foundation, it promises to be one of the largest longevity-related events ever. They’re popping up! Since the ...

This is going to be one of the coolest longevity events ever. Come to the Bay Area in spring!
www.lifespan.io/news/announc...

AI Outperforms AI-Assisted Doctors in Diagnostic Reasoning In a new study, ChatGPT 4.0 achieved significantly better diagnostic scores when evaluating complex cases than either unassisted human physicians or physicians who consulted the […]

My new article is out. Apparently, human doctors suck at using AI and refuse to rely on its insights. Also, do you think medical AI will become the great equalizer in healthcare between poor and rich countries, just like cell phones were in communication? LMK your thoughts.

So, let's begin with my interview with Dr. Mehmood Khan of the Hevolution Foundation, which was published today, and see how it goes :) Longevity is cool!
www.lifespan.io/news/mehmood...