✈️A few days ago we flew to Stockholm for the BRIDGING-RD project meeting at Karolinska University Hospital
🔬CNAG researchers Steve Laurie and @annaesteveco.bsky.social shared recent results and their expertise in bioinformatics & RNA-seq analysis to strengthen #RareDiseases research and diagnostics
📻¡Salimos en @aragonradio.bsky.social!
El periodista Marcos Ruiz entrevista a @jcnietos.bsky.social, inmunólogo en CNAG y autor de nuestra nuestra última investigación: descodificamos el líquido cefalorraquídeo para ayudar a pronosticar las enfermedades cerebrales
➡️ www.cartv.es/aragonradio/...
4️⃣ Contributions
✨The findings open new avenues for developing personalised therapies for patients with leptomeningeal diseases, with cancer cells in CSF
🔝Led by CNAG: @paulanietog.bsky.social (first author),
@hoheyn.bsky.social and @jcnietos.bsky.social
(corresponding authors), & Ginevra Caratù
3️⃣ The results
👉Individual RNA from each CSF cell, revealing how genes are activated and how cells respond to the tumour, including T-cell receptors
👉Tumour DNA to identify potential vulnerabilities
👉Spatial transcriptomics to produce a detailed map of cells in their context
4️⃣ Contributions
✨The findings open new avenues for developing personalised therapies for patients with leptomeningeal diseases, with cancer cells in CSF
🔝Led by CNAG:
@paulanietog.bsky.social (first author), @hoheyn.bsky.social and @jcnietos.bsky.social
(corresponding authors), and Ginevra Caratù
2️⃣ State-of-the-art techniques
🔬 Now, researchers from CNAG have analysed CSF for the first time using a suite of next-generation sequencing techniques
🧪 They profiled +70,000 cells from patients with CSF lymphomas, glioblastomas, brain metastases and neuroinflammatory disorders
1️⃣ A bit of context
▪️Every day, our brain is bathed and cleansed by cerebrospinal fluid (CSF)
▪️This “brain plumbing system” reaches deep into the nervous system and carries valuable information, including immune cell activity
▪️Until now, CSF has mainly been used as a diagnostic too
🚀 New paper out in @cp-cellrepmed.bsky.social!
🔝 CNAG researchers decode cerebrospinal fluid as a tool to understand the progression of brain diseases
➡️ The groundbreaking research was led by the Single Cell Genomics Group at CNAG and the
@goetheuni.bsky.social
📎 www.cnag.eu/news/cnag-re...
#PCBCommunity |🧠 Investigadors del @cnag-eu.bsky.social descodifiquen el líquid cefalorraquidi com a eina per a entendre l’evolució de les malalties cerebrals. 🔬 La recerca combina per primera vegada la biòpsia líquida amb un conjunt de tècniques de seqüenciació d’última generació.
👉 tuit.cat/StKwH
4️⃣ Contributions
✨The findings open new avenues for developing personalised therapies for patients with leptomeningeal diseases, with cancer cells in CSF
🔝Led by CNAG: @paulanietog.bsky.social (first author), @hoheyn.bsky.social and @jcnietos.bsky.social (corresponding authors), and Ginevra Caratù
3️⃣ The results
👉 Individual RNA from each CSF cell, revealing how genes are activated and how cells respond to the tumour, including T-cell receptors
👉 Tumour DNA to identify potential vulnerabilities
👉 Spatial transcriptomics to produce a detailed map of cells in their context
2️⃣ State-of-the-art techniques
🔬 Now, researchers from CNAG have analysed CSF for the first time using a suite of next-generation sequencing techniques
🧪 They profiled +70,000 cells from patients with CSF lymphomas, glioblastomas, brain metastases and neuroinflammatory disorders
1️⃣ A bit of context
▪️Every day, our brain is bathed and cleansed by cerebrospinal fluid (CSF)
▪️This “brain plumbing system” reaches deep into the nervous system and carries valuable information, including immune cell activity
▪️Until now, CSF has mainly been used as a diagnostic tool
💜 Meet the women who make CNAG!
🧬 This International Women's Day, we celebrate our colleagues driving genomics forward every day
👉 Working towards a society where women’s contributions to science are increasingly visible
#InternationalWomensDay #WomenInScience #Genomics #IWD #WomenInSTEM #CNAG
🌍 ¡CNAG en el #MWC!
Ayer pudimos disfrutar del evento organizado por @astra-zeneca.bsky.social: AI in Healthcare: Hype or Hope? Una reflexión sobre el role de la IA en biomedicina
#AstraZenecaGlobalHub #MWC26 #MWCbarcelona #MWC2026 #IA
Last week, CNAG participated in the 2nd Genomic Regulatory Network Annual Meeting, funded by @ageinves.bsky.social and hosted by @cbm-csic-uam.bsky.social
A great opportunity to share the latest results & foster collaboration
With @mamartirenom.bsky.social, Structural Genomics Group Leader at CNAG
🚀 𝗡𝗲𝘄 𝗽𝗮𝗽𝗲𝗿 𝗼𝘂𝘁 𝗶𝗻 𝘁𝗵𝗲 𝗘𝘂𝗿𝗼𝗽𝗲𝗮𝗻 𝗝𝗼𝘂𝗿𝗻𝗮𝗹 𝗼𝗳 𝗜𝗺𝗺𝘂𝗻𝗼𝗹𝗼𝗴𝘆!
A Spatial Transcriptomics Map of the Human Tonsil Reveals New Dimensions Beyond the Cellular Atlas, offering new insights into immune responses
By @pascual-reguant.bsky.social & @helucro.bsky.social (1st author)
📎 www.cnag.eu/news/spatial...
🗓️ Save the date!
Tomorrow, the @scb.iec.cat and @iec.cat will host a roundtable on the 25th Anniversary of the Human Genome, featuring leading experts in genomics, including our Director at CNAG, Ivo Gut
⏰ March 4, 17:30
📍 Carrer del Carme, 47, BCN
👉 Registration:
🚨¡Buscamos talento en CNAG!
Abrimos nuevas posiciones en Administración:
▪️Responsable de Finanzas
▪️Responsable de Personas
▪️Técnico de personal
▪️Responsable de Subvenciones y Ayudas
▪️Responsable de Contabilidad
👉 www.cnag.eu/jobs
#Empleo #Barcelona #OfertadeEmpleo #Trabajo #Vacantes #Hiring
#PCBCommunity |🧫El @cnag-eu.bsky.social cartografia el conjunt més complet de dominis proteics en retrovirus endògens humans.🔬L'estudi liderat per @annaesteveco.bsky.social amb @idibell.bsky.social ha identificat 17.540 dominis proteics retrovirals en les seqüències HERV.
👉 https://tuit.cat/125qv
🚀 New paper out in NAR Genomics and Bioinformatics!
👉 CNAG maps the most complete set of protein domains in human endogenous retroviruses
@annaesteveco.bsky.social & @tmontsay.bsky.social analysed 120K ORFs derived from HERVs, identifying 17K retroviral protein domains
www.cnag.eu/news/cnag-ma...
🙌 What a great day at #Transfiere2026!
This week, our Clinical Genomics Manager at CNAG, @lmatalonga.bsky.social, took part in the roundtable “Biomedicine-IMPaCT and Prevention” alongside @saludisciii.bsky.social, @sanidad.gob.es, and @farmaindustria.bsky.social
#ICTS #ICTSNews #IMPACT #CNAG
💜CNAG Lights Up For Rare
Tomorrow it's #RareDiseasesDay, a day to raise awareness of the 300 million people living with rare diseases worldwide
At CNAG, we improve diagnosis through genomics and help families find answers
#LightUpForRare @rarediseaseday.bsky.social @erdera.bsky.social #rarediseases
#RareDiseaseDay is an opportunity to recognise the 30 million people in Europe living with a rare disease. As a partner in @erdera.bsky.social, we're working together to advance prevention, diagnosis, and treatment
Proud to be part of a community making more impact than you can imagine 🤝
🚀 A new #BreastCancer project takes off: HER-CARE!
🩷 A doctoral training programme on Hereditary and Early-onset breast cancer
🎯 Our role: determine how germline and somatic variants affect protein structure, using an AI-based classifier to analyse them
📎 www.cnag.eu/projects/her...
#CancerdeMama
🙌¡Qué gran día en #Transfiere2026!
Ayer, nuestra Responsable de Genómica Clínica en Centro Nacional de Análisis Genómico, @lmatalonga.bsky.social, participó en la mesa redonda “Biomedicina-IMPaCT y prevención” junto a @saludisciii.bsky.social, @sanidad.gob.es y @farmaindustria.bsky.social
@Fycma
🚨Call for Abstracts and Registration Open!
Join us at the European Society for Spatial Biology Conference - Painting a New Biology!
🗓️September 28th to October 1st, 2026
📍Hotel Melià Sitges (Barcelona, Spain)
👉Organised with the support of CNAG (@pascual-reguant.bsky.social)
essb2026.org
#essb
💫The study, led by CNAG, @cabd-upo-csic.bsky.social and the Duke University Medical Center, is a further step to understand non-coding regulatory regions and 3D hubs that coordinate gene expression, laying the foundation for more precise genome engineering and modification of gene expression
5️⃣ 𝘈𝘱𝘱𝘭𝘪𝘤𝘢𝘵𝘪𝘰𝘯𝘴
These findings show how the same gene can play distinct roles in different tissues, as illustrated in mammalian sex determination. They also provide a foundation to better understand a group of conditions, such as Differences of Sex Development (DSD)
#RealApplications #HumanHealth
4️⃣ 𝘛𝘩𝘦 𝘳𝘦𝘴𝘶𝘭𝘵𝘴
Using the geostatistics-inspired method, researchers identified a novel regulatory region controlling Fgf9, a key gene downstream of Sry that activates Sox9 and triggers testis development, as well as new regulatory networks including the Meis1 and Meis2 genes
#Computational #Biology
