Yang Luo

A blue and white poster reads "MRD Centre of Research Excellence in Exposome Immunology, External Seminar: Integrating cohorts and multi-omics to capture the earliest determinants of disease and aging". The speaker is Professor Philip Awadalla from the University of Oxford. 9 February 2026. Kennedy lecture theatre. 12:30-13:30. Open to all members of the University of Oxford. Hosted by Yang Luo.

On Monday 9 February, Professor Philip Awadalla will join us to present 'Integrating Cohorts and Multi-Omics to Capture the Earliest Determinants of Disease and Aging'. Our External Seminars are open to any member of the University of Oxford. Don't miss it! talks.ox.ac.uk/talks/id/19a...

A photo of me that is about 10 years old, and details on the webinar: "Inside the world's largest metabolomics study: Insights from UK Biobank, 21st January 2026, 3pm (GMP), Register now".

We have a webinar next week with @ukbiobank.bsky.social on the Nightingale metabolomics data. We did a table read today, and it is shaping up really nicely. Please do come! 300 people have registered already and there are only np.inf spaces left!

www.ukbiobank.ac.uk/use-our-data...

Great round of talks from the team at the SMARTbiomed Symposium at Oxford today.

Kennedy Trust for Rheumatology Research (KTRR) Group Leader in Microbiome Studies (183704) We are seeking applications from an outstanding scientist to establish and lead a new research group in human microbiome science, advancing understanding of microbe–microbe and microbe–host interactio...

Hiring: Group Leader in Microbiome Studies! ✨

The successful candidate would establish & lead a new research group in human microbiome science, advancing understanding of microbe-microbe and microbe-host interactions in health & disease.

Apply by 22 Dec.

www.ndorms.ox.ac.uk/jobs/kennedy...

annual Xmas dinner - blessed with a wonderful team🥰

📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...

tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.

We have a new open position to analyze large-scale genomic datasets and EHR data to better understand and improve care for type 2 diabetes and monogenic diabetes, in collaboration with Chirag Patel, Miriam Udler, Aaron Leong, and many others. Please share! broadinstitute.avature.net/en_US/career...

Improving population-scale disease prediction through multi-omics integration https://www.medrxiv.org/content/10.1101/2025.11.24.25340920v1

Improving population-scale disease prediction through multi-omics integration The early detection of common diseases is currently constrained by a dependence on single biomarkers, which often capture only a limited aspect of disease pathology. Here, we applied multi-omic factor...

Oops link is broke due to emoji, here’s a fixed one:

www.medrxiv.org/content/10.1...

If you’re interested in:
🧬 multi-omics
📊 dimensionality reduction
🩺 disease risk prediction
🏥 large cohort analysis

…we’d love for you to check it out, and pin me if you have any comments or feedback — would love to hear your thoughts!

This is a great collaborative effort among many amazing colleagues, particularly supports from
@lukejostins.bsky.social, @jeffbarrett.eu
and Prof. John Todd

📈 For certain diseases, such as diabetes and anaemia, these factors improve disease prediction, reveal cross-disease biology, and move us closer to population-scale precision medicine.

These latent factors:
✔ summarise thousands of molecular features
✔ reflect core biological processes
✔ generalise across diverse diseases

👇

🧬 Common diseases share biology, but we often predict them using single biomarkers.
We asked: Can multi-omics do better?
Using multi-omic data from @ukbiobank.bsky.social, we identify latent omic factors that capture shared pathways influencing many diseases simultaneously.

🚨 New preprint from the lab!
We’re excited to share “Improving population-scale disease prediction through multi-omics integration” by Ng et al. www.medrxiv.org/content/10.1...

🧷Pin me if you have any comments or feedback. We'd love to hear your thoughts!

This is a great collaborative effort among many amazing colleagues, particularly supports from @lukejostins.bsky.social , @jeffbarrett.eu and Prof. John Todd

📈 For a number of diseases, such as diabetes and anaemia, these factors improve disease prediction, reveal cross-disease biology, and move us closer to population-scale precision medicine.

✨ Using genomics, proteomics & metabolomics, we identified latent omic factors that capture shared molecular signatures across many diseases.

🧬 Common diseases share biology, but we often predict them using single biomarkers.
We asked: Can multi-omics do better?

Amazing work! Congrats @linoafferreira.bsky.social !

Interactions with polygenic background impact quantitative traits in the UK Biobank Association studies have linked many genetic variants to a variety of phenotypes but under-standing the biological mechanisms underlying these signals remains a major challenge. Since genes operate wi...

Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank!

A thread... 🧵

www.medrxiv.org/content/10.1...

Some talks are good, some are exciting, and some are truly inspirational. This is one of them — “Smarter trials for better health” by Sir Martin Landray. @martinlandray.bsky.social

✨ It was a real pleasure to host @mikeinouye.bsky.social today! A fantastic seminar connecting polygenic scores with multi-omic profiles — showing how integration can power next-generation disease prediction. #systemgenomics

One more week to go! Come and join us for this exciting Exposome journey.

Postdoctoral Research Assistant - MRC CoRE in Exposome Immunology (182449) You will lead on the delivery of the assigned CoRE research project and manage own academic research and administrative activities, using initiative to drive these forwards in a rigorous, efficient an...

We are #hiring a postdoc as part of the new MRC CoRE in Exposome Immunology!

The role will systematically explore the impact of the exposome on complex disease risk, through the lens of multi-omics data.

Apply by 5 Nov 👇

www.kennedy.ox.ac.uk/jobs/postdoc...

Excited to be working with this amazing group!

We’re delighted to hear that our favourite cell type (Regulatory T cells!) have been recognised in the Nobel Prize this year! Huge congratulations to Mary, Fred, and Shimon for their pivotal work in the field & here’s to many exciting Treg advances to come!🥳👏🎉

🌟 Postdoc Opportunity – MRC CoRE in Exposome Immunology 🌟
Join us to explore how the exposome shapes complex disease risk using multi-omics & global biobank data. @kiroxford.bsky.social , @exposomeimmunology.bsky.social

✅ Apply: lnkd.in/gJHJDvKn

🗓️ Deadline: 12pm, 30 Oct 2025

@soumya-boston.bsky.social when are you coming ? ;-)