Hannah Garner

Excited to share this highlight of a beautiful study into how myeloperoxidase acts as a chromatin transformer

Immunofluorescence images of CF patient sputum samples stained for DNA and MPO, respectively. The layover on the right shows that MPO and DNA nicely overlap.

As a final note, this whole process is highly relevant not only for killing pathogens, but also in autoimmune diseases.

We could also show that sputum of cystic fibrosis patients contains high levels of MPO functionalised NET-like structures.

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...

🥳🥳🥳Countless years in the making and there it is 🫶🏻
Exceptionally proud of my lab and especially Lance who was driving this project for the last years! 🏎️Thank you to all the fantastic collaborators ♥️ I hope everyone enjoys reading our little story! www.nature.com/articles/s41...

Canadian Excellence Research Chair (CERC) in Human Immunology Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Are you an established PI that studies the human immune system and looking for a change of location? If the answer is yes, #McGill has an amazing opportunity to provide long-term funding at a world class institution. Apply now!!!! Please repost!!! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Tumor neutrophils rewired from birth Systemic responses during tumor progression reshape granulopoiesis. In this issue of Cancer Cell, Garner et al. show that tumor-derived signals reprogram neutrophil development early in myelopoiesis. ...

Thank you to Lai Guan Ng and Lihui Dong for highlighting our work! www.cell.com/cancer-cell/...

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...

Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social

www.cell.com/immunity/abs...

This meeting looks fantastic 🤩

Signaux longue distance et métastases de cancer du sein : une histoire de neutrophiles | Institut du cancer Goodman Une nouvelle étude menée par Hannah Garner, Ph.D., nouvellement chercheuse à l’Institut du cancer Rosalind et Morris Goodman (ICG), publiée dans le journal Cancer Cell, a montré que les cellules...

Une étude mené par @hannahgarner.bsky.social (ICG), montre que les précurseures des #neutrophiles reçoivent des signaux des tumeurs mammaires et aident les #métastases. Collaboration avec @nkinl.bsky.social, Moreno Martinovic, Karin de Visser et @dewitlab.bsky.social. Détails: tinyurl.com/4b5n5psu

Long distance signalling and breast cancer metastatic spread: a neutrophil story | Goodman cancer Institute A recent study from Hannah Garner, Ph.D. and new member of the Rosalind and Morris Goodman Cancer Institute (GCI), published in Cancer Cell, showed that neutrophil precursors located in the bone marrow receive signals from mammary tumours and promote metastasis.

A new study co-led by GCI member @hannahgarner.bsky.social showed how #neutrophil precursors receive signals from mammary tumours and promote #metastasis. Incredible collaboration with @nkinl.bsky.social, Monreno Martinovic, Karin de Visser and @dewitlab.bsky.social. Details: tinyurl.com/4c2snae6...

All very strong but I love NoBS… might have to edit previous post…

9/n I’m excited to continue to research the interplay between haematopoiesis, inflammation and cancer progression and how we can therapeutically target chronic inflammation in my new lab @mcgillgci.bsky.social

8/n Huge thanks to amazing collaborators @dewitlab.bsky.social for amazing collaboration and to the KWF for funding

7/n Huge thank you to Bluesky-less Karin de Visser for being the best postdoc mentor possible and all her support through the years including 2 mat leaves and covid!

6/n leading to a reversal of neutrophil immunosuppressive phenotype and reduced metastatic spread

5/n Can this tumour-driven education be reversed? Yes! We found treatment with clinically relevant anti-IL-1b normalized tumour-induced granulopoiesis at cellular, transcriptomic and chromatin levels

4/n really intriguingly, we find that tumour-driven immunosuppressive imprinting of neutrophils starts early in haematopoiesis and we can identify genes associated with immunosuppression upregulated in haematopoietic stem cells

3/n Using single-cell, chromatin and functional analyses we unravel tumour-driven reprogramming of granulopoiesis in the bone marrow and find that mammary tumours accelerate commitment to the neutrophil lineage at the expense of lymphocytes and RBCs

2/n We asked how do distant mammary tumours reprogram neutrophil development at the molecular level and when does tumour imprinting occur during neutrophil development

1/n Mammy tumours drive systemic inflammation: in 🚺 and 🐁 we see increased circulating neutrophils that are polarized to an immunosuppressive phenotype which promotes metastatic spread

Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread Tumor-induced systemic accumulation and polarization of neutrophils to an immunosuppressive phenotype is a potent driver of metastasis formation. Yet,…

💥 Really excited to say that our paper with Karin de Visser and @dewitlab.bsky.social is now online! A beautiful story to culminate years of great collaboration and teamwork at the @nkinl.bsky.social. A 🧵

www.sciencedirect.com/science/arti...

Macrophages direct location-dependent recall of B cell memory to vaccination Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…

#LocationLocationLocation! @labphan.bsky.social @ramadhenni.bsky.social Hoppé &co show @cp-cell.bsky.social that subcapsular sinus macrophages interact with memory B cells, positioning them in a subcapsular niche that favors their rientry in germinal centers & more rapid antibody responses!

Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...

New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....

The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative The Marathon of Hope Cancer Centres Network (MOHCCN), led by the Terry Fox Research Institute and the Terry Fox Foundation, unites researchers, clinicians, patients, funders, and other partners across Canada to accelerate precision oncology, promote collaboration and data sharing, and ultimately improve patient outcomes. This overview outlines the Network’s goals, history, and challenges and opportunities. We also highlight progress toward the “MOHCCN Gold Cohort,” a shared resource of clinical and genomic data from 15,000 patients.

Online Now: The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative