We show that outer membrane stresses activate the DbfQRS pathway, rewiring global gene expression across biofilms regulation, central metabolism, and stress responses, with measurable fitness costs in an infection model - highlighting DbfQRS as a potential target for anti-infective strategies
In this work, we identify DbfQ, a small periplasmic protein that serves as a key regulator of the DbfRS two-component system, coordinating broad physiological adaptations in Vibrio cholerae.
Thrilled to share that my first-author paper is now published in Nature Communications! 🎉 Huge thanks to my PI, Dr. Drew Bridges (@bridgesbio.bsky.social), my collaborators, and all the incredible lab members for their support throughout this project
www.nature.com/articles/s41...
Honored to have presented my work on the DbfQRS pathway at the 2025 #ASMBiofilms Conference! Sharing research from the Bridges Lab and connecting with many brilliant minds in the field was such an inspiring experience. Grateful for the opportunity and energized for what's next!
Had a chance to present my work at the Gordon Research Conference on Microbial Adhesion and Signal Transduction. I'm so grateful for this opportunity to listen to inspiring talks, make new connections, receive advice, and engage in meaningful discussions in such a dynamic and supportive environment!
Check out our lab's latest work in @plos.bsky.social, which reveals biofilm dispersal patterns using FAP-fluorogen labeling approach.
#Microsky
Biofilm Starter Pack on the Blue place
go.bsky.app/HF1jeCQ
Welcome refugees from X! Follow microbiologists and more in the @binningsingletons.com and Friends Starter Pack!
go.bsky.app/H5k2p2g
go.bsky.app/L3L2iFz
Missed capture of the amazing movies of biofilm dispersal by @bridgesbio.bsky.social at #RBM2024 but you can read / see here www.biorxiv.org/content/10.1...
Keep up the excellent work! 👏
Last and certainly not least, @markjmandel.bsky.social presenting research about regulation of the most charismatic microbiome-of-one, the squid-Vibrio symbiosis #RBM2024
Thank you for stopping by Mark! Your talk today at #RBM2024 was really insightful!
Thrilled to have presented my research in the lab of @bridgesbio.bsky.social at three conferences this year: Bacteria and Phages, ABASM, and Rust Belt Microbiome. Grateful for the chance to share my work and connect with inspiring scientists. Can't wait to see what future conferences bring!
