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Pilar Cacheiro

@pilarcacheiro

Computational biologist. Genetics of Rare Diseases, Essential Genes, Statistics, R. Honesty matters.

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06.12.2023
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Latest posts by Pilar Cacheiro @pilarcacheiro

A crow says "I just want to"

A crow says "I just want to"

"Focus" Crow is now very detailed and crouching down

"Focus" Crow is now very detailed and crouching down

27.02.2026 20:41 ๐Ÿ‘ 4671 ๐Ÿ” 1372 ๐Ÿ’ฌ 11 ๐Ÿ“Œ 16
Western view of Washington Park Beach and the inlet to Michigan City Harbor in Michigan City with Lake Michigan beyond. // Image captured at: 2026-02-27 22:36:18 UTC (about 1 min. prior to this post) // Image sourced from: youtube.com/@AccessLaPorteCountyMedia // Current Temp in Michigan City: 65 F | 18 C // Precip: broken clouds // Wind: SW at 11 mph | 17 kph // Humidity: 33%

Western view of Washington Park Beach and the inlet to Michigan City Harbor in Michigan City with Lake Michigan beyond. // Image captured at: 2026-02-27 22:36:18 UTC (about 1 min. prior to this post) // Image sourced from: youtube.com/@AccessLaPorteCountyMedia // Current Temp in Michigan City: 65 F | 18 C // Precip: broken clouds // Wind: SW at 11 mph | 17 kph // Humidity: 33%

Current* conditions near Michigan City, IN:

27.02.2026 22:36 ๐Ÿ‘ 7 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Close-up of black and white woodpecker with long sharp beak, gripping a smooth barked tree trunk in front of a big hole he has excavated.

Close-up of black and white woodpecker with long sharp beak, gripping a smooth barked tree trunk in front of a big hole he has excavated.

Wider view of same bird.

Wider view of same bird.

Wider view this time with his head tilted back so the hole is obvious.

Wider view this time with his head tilted back so the hole is obvious.

The Hairy Woodpecker content you didnโ€™t know you needed
#birds

28.02.2026 00:20 ๐Ÿ‘ 232 ๐Ÿ” 29 ๐Ÿ’ฌ 12 ๐Ÿ“Œ 1
้‡Ž้ณฅใŒใŸใใ•ใ‚“ๆใ‹ใ‚ŒใŸใ‚นใƒžใƒ›ๅฃ็ด™็”จใ‚คใƒฉใ‚นใƒˆ

้‡Ž้ณฅใŒใŸใใ•ใ‚“ๆใ‹ใ‚ŒใŸใ‚นใƒžใƒ›ๅฃ็ด™็”จใ‚คใƒฉใ‚นใƒˆ

ๅฃ็ด™

28.02.2026 04:15 ๐Ÿ‘ 2311 ๐Ÿ” 813 ๐Ÿ’ฌ 11 ๐Ÿ“Œ 12

๐Ÿ“ข New study presents DeepRare, an agentic LLM-based system for rare disease prioritization.
๐Ÿงฌ It generates ranked diagnostic hypotheses from multimodal patient data with evidence-based reasoning, outperforming other approaches in diagnostic accuracy.

www.nature.com/articles/s41...

25.02.2026 09:46 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Preview
Humbled by Evolution Understanding the history and diversity of life inspires awe and wonder.

1. Iโ€™m quite happy with this popular piece that Lee Dugatkin and I wrote recently. For the next two weeks itโ€™s free to read on the American Scientist website.

17.02.2026 19:25 ๐Ÿ‘ 195 ๐Ÿ” 75 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 6
Post image

Interested in pursuing a PhD at EMBL-EBI?
@atsocf.bsky.social ๐Ÿ‡ฎ๐Ÿ‡น is one of our PhD fellows. He works on improving #AlphaFold protein structure predictions.

Find out more about his PhD experience:
www.ebi.ac.uk/about/news/p...

16.02.2026 11:29 ๐Ÿ‘ 15 ๐Ÿ” 6 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Some exciting openings in Exeter for clinical academics (professor and senior lecturer). Come and shape the future of translational genomic medical research in the South West! Lovely place to work, lovely people to work with, and freedom to pursue great science... www.linkedin.com/jobs/view/43...

09.02.2026 10:09 ๐Ÿ‘ 7 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2

โฐ Only two more weeks to go!

The abstract submission deadline for #ESHG2026 #HybridConference is fast approaching.
๐Ÿ—“๏ธ Deadline: Thursday, 12 February 2026, 23:59 CET

Donโ€™t forget to submit your abstract!
๐Ÿ‘‰ All details here: 2026.eshg.org/abstracts/

30.01.2026 09:22 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Por supuesto. Y no solo en Suecia. Aprender por el placer de aprender. Que casi se nos ha olvidado lo que es eso:
www.udc.es/en/senior/

26.12.2025 10:56 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

I'm on the Board of @biologists.bsky.social. Many know them as publishers of @dev-journal.bsky.social, @jcellsci.bsky.social, @jexpbiol.bsky.social , DMM, and @biologyopen.bsky.social --but they also are a major funder of small grants that empower young biologists and enable scientific meetings ๐Ÿงช

22.12.2025 12:26 ๐Ÿ‘ 64 ๐Ÿ” 21 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

I guess the preprint came out in 2024 but it was published this year so I'll say this paper from @jeffspence.github.io and @hakha.bsky.social which is probably the paper that pleiotropy-pilled me the most. Really got me to think about what GWAS means www.nature.com/articles/s41...

21.12.2025 06:07 ๐Ÿ‘ 43 ๐Ÿ” 10 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1
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The โ€œmachinal bypassโ€ and how weโ€™re using AI to avoid ourselves | PNAS The “machinal bypass” and how we’re using AI to avoid ourselves

Love this short opinion piece on โ€œmechanical bypassโ€ in analogy to โ€œspiritual bypassโ€.

21.12.2025 04:42 ๐Ÿ‘ 180 ๐Ÿ” 63 ๐Ÿ’ฌ 9 ๐Ÿ“Œ 7
'MODERN-DAY DAY ORACLES or BULLSHIT MACHINES? How to thrive in a ChatGPT world Developed by Carl T Bergstrom and Jevin D. West Yet for all the good that AI systems will do, they will also saturate our information environment with bullshit at ata a scale never before encountered.'

'MODERN-DAY DAY ORACLES or BULLSHIT MACHINES? How to thrive in a ChatGPT world Developed by Carl T Bergstrom and Jevin D. West Yet for all the good that AI systems will do, they will also saturate our information environment with bullshit at ata a scale never before encountered.'

Whether we like it or not, AI is here and not going anywhere. The excellent colleagues behind @callingbullshit.bsky.social (@jevinwest.bsky.social & @carlbergstrom.com) now have a great resource to help us understand AI and how to deal with it. Highly recommended!
thebullshitmachines.com/index.html

06.09.2025 19:54 ๐Ÿ‘ 43 ๐Ÿ” 19 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 3
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โ€˜Almost unimaginableโ€™: these ants are different species but share a mother Ant queens of one species clone ants of another to create hybrid workers that do their bidding.

A common type of ant in Europe breaks a fundamental rule in biology: its queens can produce male offspring that are a whole different species

go.nature.com/4mOb5T9

03.09.2025 15:34 ๐Ÿ‘ 290 ๐Ÿ” 130 ๐Ÿ’ฌ 7 ๐Ÿ“Œ 65
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One mother for two species via obligate cross-species cloning in ants - Nature In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...

Look at this crazy thing!
www.nature.com/articles/s41...

03.09.2025 19:05 ๐Ÿ‘ 151 ๐Ÿ” 64 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 29

One of those days when you feel very lucky to have the job you do. Everyone is working hard, your colleagues go the extra mike to support you, and things work out, even if at the last minute.

19.08.2025 18:16 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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I guess art is there for us to agree or disagree with.

15.08.2025 22:26 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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N2 sleep promotes the occurrence of โ€˜ahaโ€™ moments in a perceptual insight task Sleep supports memory consolidation, but can it also facilitate memory reorganization? This study reveals that N2 sleep, but not N1 sleep during a nap, increases the likelihood of having an 'aha' mome...

My one and only reply from now on to anyone making fun of Spaniards for their siesta habits.
journals.plos.org/plosbiology/...

07.08.2025 17:37 ๐Ÿ‘ 6 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

This sounds true to me

05.08.2025 10:34 ๐Ÿ‘ 32 ๐Ÿ” 7 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0
Poem title: At the Intersection
 
The poem is divided into two overlapping circles.
 
The left-hand circle is titled โ€˜meโ€™ and the text reads:
the day we
went out to have
an ice-cream, we said nothing
just let our silence melt in
the air as we walked across the common
our love never tiring at all
 
The right-hand circle is titled โ€˜youโ€™ and the text reads:
we should
have talked it over but
nothing ever seems to get
in your fat head. You are so
common that I wish weโ€™d never met
at all and Iโ€™d married Tim instead
 
In the intersection of the poem (where the two circles overlap), the text reads:
we
have
nothing
in
common
at all

Poem title: At the Intersection The poem is divided into two overlapping circles. The left-hand circle is titled โ€˜meโ€™ and the text reads: the day we went out to have an ice-cream, we said nothing just let our silence melt in the air as we walked across the common our love never tiring at all The right-hand circle is titled โ€˜youโ€™ and the text reads: we should have talked it over but nothing ever seems to get in your fat head. You are so common that I wish weโ€™d never met at all and Iโ€™d married Tim instead In the intersection of the poem (where the two circles overlap), the text reads: we have nothing in common at all

The mathematician John Venn was born on this day in 1834. To commemorate the occasion, hereโ€™s a poem in the form of a Venn diagram.

04.08.2025 09:27 ๐Ÿ‘ 613 ๐Ÿ” 222 ๐Ÿ’ฌ 26 ๐Ÿ“Œ 14
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If I ever get rich I won't tell anyone, but there will be signs.

02.08.2025 13:32 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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So long, and thanks for all the fish.

29.07.2025 19:19 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Not entirely sure what the lunch menu is, but it sure made fishing look easy.

27.07.2025 13:08 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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If you were a gannet, where would you want to live?

25.07.2025 19:10 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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We all need a rest sometimes.

24.07.2025 11:15 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Complex genetic variation in nearly complete human genomes - Nature Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in @nature.com by @glennislogsdon.bsky.social & colleagues. ๐Ÿ‘‡๐Ÿงฌ๐Ÿงช

23.07.2025 16:19 ๐Ÿ‘ 86 ๐Ÿ” 39 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
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MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

๐Ÿ“ข We're hiring 5 postdocs across multiple projects!
Spanning germline demethylation, gene regulation and genome architecture in development and disease!

Apply now!

21.07.2025 15:37 ๐Ÿ‘ 18 ๐Ÿ” 13 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Multiplexed assays of variant effect for clinical variant interpretation Nature Reviews Genetics - Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et...

Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU

21.07.2025 19:33 ๐Ÿ‘ 69 ๐Ÿ” 32 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1

Remember folks, your AI is only as good as the training data and so it looks backwards rather than forwardsโ€ฆ.

21.07.2025 06:32 ๐Ÿ‘ 29 ๐Ÿ” 17 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1