Heidi Pak, Ph.D.

Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging - Nature Aging Yeh et al. explore the effects of restricting dietary protein, or isoleucine specifically, in aged mice. They uncover benefits to metabolic health and certain indicators of aging and a sexually dimorp...

Pleased to announce the publication of our new manuscript, "Late-life protein or isoleucine restriction
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk

Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions Pak et al. find that many canonical effects of calorie restriction, including insulin sensitivity, result from the specific temporal conditions chosen. Feeding time, fasting duration, and the time of ...

It depends on the question! I recommend having a minimum of two time-points as metabolite levels seem to be rhythmic. Please check out my paper, figure 4 as an example www.cell.com/cell-reports...

Happy to restart my science network here. Please add me if you are a metabolism, aging, feeding behavior, and circadian rhythms enthusiast!