Our latest work "Computed atlas of the human GPCR-G protein signaling complexes" is online as a preprint on biorxiv: biorxiv.org/content/10.6... Led by Pasquale Miglionico and Marin Matic, it provides the first computational atlas of the entire human GPCRome in complex with G proteins.

Two men standing at a table, smiling to camera.

We announce changes in EMBL leadership as Edith Heard steps down as Director General.

EMBL will be led jointly by Peer Bork as Interim Director General and Ewan Birney in a new role of Executive Director until the appointment of EMBL’s next Director General.

www.embl.org/news/embl-an...

GitHub - DunbrackLab/IPSAE: Scoring function for interprotein interactions in AlphaFold2 and AlphaFold3 Scoring function for interprotein interactions in AlphaFold2 and AlphaFold3 - DunbrackLab/IPSAE

If you read this far, you get the Code: github.com/DunbrackLab/... . Runs on AF2, AF3-server, and AF3-local json files and their pdb/mmCIF files. No special flags. MIT license. Let me know of any bugs or questions. End 🧵.

Learning and actioning general principles of cancer cell drug sensitivity - Nature Communications Potential anti-tumor therapies remain to be discovered in cancer cell line high-throughput screening datasets. Here, the authors develop a machine learning approach to infer cancer cell drug sensitivi...

An innovative strategy to identify potential anti-cancer drugs using patients' transcriptomics data has been developed by the Bioinformatics group at BIO@SNS Lab, Scuola Normale Superiore.
Read the study on Nature Communications
#CancerResearch #Bioinformatics #Science
www.nature.com/articles/s41...