To activate plant immunity, NLR receptors such as SUMM2 form resistosome complexes, which act as Ca2+-permeable plasma-membrane channels. Work @nature shows how SUMM2 and its associates assemble into even higher-order clusters to initiate cell death.
shorturl.at/653TZ
plus N&V
shorturl.at/vqqYg
@Nature: an E3 ligase, acting via the jasmonate pathway, is a common regulator of both cold stress & phosphate uptake. Guided by AI, the authors use genome editing to show the relevance of this finding for improving maize yield in multi-site field trials.
shorturl.at/KrKBo
& NV
shorturl.at/rwldu
Lipid transfer proteins (LTPs) maintain the specific lipid compositions of cellular membranes. @nature, a systematic characterization of complexes between human LTPs and their lipid cargo provides a resource for a better understanding of these proteins.
www.nature.com/articles/s41...
The journal Nature is looking for a Metabolism and Cardiovascular biology editor -- deadline coming soon.
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Disruption of protein import into mitochondria affects cellular balance and can cause disease. Work @nature shows that cells sense this defect through inter-organelle communication and a signalling role of mitochondrial targeting sequence.
www.nature.com/articles/s41...
One environmental factor that affects crop yield is soil stress. Work @nature shows how soil compaction stress affects plant root growth through hormonal signals and cell-wall remodelling.
www.nature.com/articles/s41...
On plant cells, receptor-like kinases mediate both immune and symbiotic signalling. Work @nature provides amino-acid-level molecular insights into how signalling specificity is achieved downstream of such similar receptors.
www.nature.com/articles/s41...
The >1000 lipid species found in eukaryotic cells have vital functions. Using a combination of microscopy, spectroscopy and modelling, authors report @nature the first quantitative map of retrograde flux of individual lipids in cells.
An @nature paper presents a single-cell multi-omics atlas of eight rice organs. Insights emerging from this resource include new cell states during rice development and correlations between cell type and agronomic traits.
www.nature.com/articles/s41...
In today’s issue of @nature, read a Review article on the latest and upcoming technologies that could aid research and development in crop science, contributing to sustainable global food security. www.nature.com/articles/s41...
Plant NLR receptors mediate pathogen resistance, and so their engineering could lead to crops with broader pathogen specificity and so broader disease resistance. @nature, authors report one such attempt achieving resistance to several potyviruses. www.nature.com/articles/s41...
& shorturl.at/932j7
How the plant defence hormone salicylic acid (SA) is formed in some bacteria and in Arabidopsis is well-established. Three @nature papers now describe a different pathway of SA biosynthesis in non-Brassicaceae plants.
rb.gy/9tgn8g
shorturl.at/fYAYo
shorturl.at/UCvo0
& NV
tinyurl.com/bdz2p6dx
Very much looking forward to hearing and seeing exciting research and to interacting with reseachers at #2025ISMPMI. Happy also to answer any questions about publishing in Nature and sister journals.
How do plants notice loss of structural barriers (e.g. the periderm, which prevents water loss and pathogen infection) to regenerate them? Work @nature shows that plants sense damage to barrier integrity from diffusion of gases such as ethylene and oxygen. shorturl.at/FIhJ8
& N&V
shorturl.at/u7PYs
A bottleneck for studying the biological function of biomolecular condensates is unavailability of tools to selectively probe them within living cells. @nature, researchers report one such tool, showcasing its use in various contexts including disease. www.nature.com/articles/s41...
The diverse cellular roles of early endosomes involve coordinated activity of several hundred integral membrane proteins and transiently associated regulatory complexes. A study @nature presents a systematic structural interactome of human endosomes . www.nature.com/articles/s41...
Want a taster of working as an editor? Nature has a locum position open for someone with interest in stem cell biology, developmental biology, and/or specific aspects of general cell biology. springernature.wd3.myworkdayjobs.com/SpringerNatu...
Legume can form symbiotic relationship with some bacteria, while recognising others as pathogens. Work @nature identifies a plant kinase that mediates this nuanced balance of tolerance towards symbionts without compromised plant immunity. www.nature.com/articles/s41...
The E3 ubiquitin ligase complex SIFI has a role in terminating stress response signalling, to restore cellular homeostasis. Researchers @nature present the cryo-EM structure of this ~1.3 MDa complex providing insights into its mechanism of action. www.nature.com/articles/s41...
Plant roots adapt to their environment including to soil conditions. Using single-cell transcriptomics, @nature authors report on the rice root responses and adaptations to soil-related stresses at individual cell level. www.nature.com/articles/s41...
At membrane contact sites, bridge-like transport proteins, e.g. LPD-3, mediate bulk lipid transfer between cellular organelles. @nature see cryo-EM structure of native LDP-3, and gain insights into its functioning and interaction with other proteins and lipids.
shorturl.at/lycuz & shorturl.at/ARpUK
The technique of haploid induction creates homozygous plants, enabling faster breeding cycles. A paper @nature discovers a way of generating haploid sunflower, and optimises the approach for efficiency compatible with breeding programs for this important oilseed crop. rb.gy/vrqana & N&V rb.gy/e7uyep
Proteins and nucleic acids move in and out of the nucleus through nuclear pore complexes (NPCs). Using 3D MINFLUX, @nature authors study single import and export events, gaining detailed insights into transport across NPCs within cells and at nanometer and millisecond scales.
shorturl.at/2ClQp
Vector-borne viral pathogens are threats to crops, and so trigger plant immune responses. Studying rice, authors @nature provide molecular-level insights into the first steps of plant antiviral response.
www.nature.com/articles/s41...
While work @nature recently showed that the TIR1/AFB receptors of the plant hormone auxin have adenylate cyclase activity, further work now shows the broad physiological significance of this activity during plant development, via transcriptional reprogramming.
www.nature.com/articles/s41...
@nature, an extensive study, involving 18 KO and mutant mouse models, reveals why Parkin KO mice grow normally. It finds that the Parkin-mediated mitochondrial quality control works alongside another such pathway, involving Oma1.
www.nature.com/articles/s41...
In plant immunity, activated sensor NLRs generate second messengers, which in turn activate helper NLRs such as NRG1. Two studies @nature use cryo-EM to provide mechanistic insights into NRG1 activation and inhibition.
www.nature.com/articles/s41...
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www.nature.com/articles/s41...
Initiation of symbiosis between legumes and nitrogen-fixing microorganisms involves Ca2+ oscillations in root cells. Work @nature provides insights into molecular fine-tuning of the Ca2+ oscillations, and show the transfer of this beneficial trait to wheat.
www.nature.com/articles/s41...
