Alan Brown

Congratulations! Exciting news!

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

Delighted to have contributed to this paper and amazing resource. In-silico protein-protein interaction screening has huge promise for generating novel hypotheses and building models into low-res #cryo-EM and #teamtomo maps.

Our latest collaborative effort - with Eva Gluenz and @zephyris-science.bsky.social - to understand how the various proteins and complexes of the axoneme contribute to ciliary motility:

Very excited to share this one! Our comprehensive structure, genetics and biophysics dissection of which flagellar dyneins and other proteins are needed for flagella to beat and drive cells swimming behaviours: www.biorxiv.org/content/10.1...

Watching Sven elucidate this mechanism from an unbiased screen onwards has been one of my favorite experiences as a PI. In these challenging times for science at Harvard, it reminds me of the sheer joy of doing science and making discoveries.

Mark your calendars! The CSHA Cilia & Centrosomes meeting returns this November 2025, can’t wait for what’s sure to be an exceptional gathering of the community.

Hi Max, we hope to get the preprint submitted in the next few days. I'm sure Sven will post it when it's available.

Unfortunately, we can't offer a hybrid option. Our agreement with the venue is for an in-person meeting only.

Text overlaying a grid of cryo-EM images of heterogeneous samples. Text: Cryo-EM Summer Workshop, June 1-5, 2025.

*Deadline extended*
Applications for this year's #CryoEM Data Processing Workshop are due March 27!
Don't miss this chance to learn about various approaches to deal with conformational/compositional heterogeneity.
myumi.ch/lsi-cryo-2025
@jbquerido.bsky.social
@shyamalm.bsky.social

The insides of microtubules of motile cilia and flagella are coated in proteins - but are they all important for motility? Our latest collaborative study addresses this question using trypanosomatids as model organisms. Matt explains more below:

A reminder that the Brown lab has an opening for a postdoc fellow: brown.hms.harvard.edu/jobs/242. This might suit someone from the #cilia community interested in learning structural biology. Deadline extended to the 10th Jan.

This was a great collaboration and culmination of a huge amount of work including our first attempt to join #teamtomo. @ruizhangmt.bsky.social expertly summarizes the highlights below:

Congratulations!

Deadline alert: "Biophysics of Motile Cilia": Apply before Dec 1st for consideration for contributed talks! Topics: #axoneme mechanics, #synchronization, #navigation, #ciliopathies, ... Meet us in Bad Honnef, Germany, 30.03.-02.04.2025 we-heraeus-stiftung.de/veranstaltun... Please re-sky!