Raquel Pérez Palacios

Many women delay motherhood past 30 due to economic and career pressures. Could this impact fertility? What does science say? With Nacho de Blas & María Climent 🔊

Listen here! cartv.es/aragonradio/po…

@aragonradio @BlasIgnacio

#Aging #FemaleFertility
#ScienceCommunication

3, 2, 1, rolling!
Our short film project has already begun, and we got the chance to film an expert in gametogenesis and embryology, our dearest Dr. Pedro Muniesa. So eager to watch the result! More to come soon…

This week, filming officially began 🎥🔬

With excitement (and a few nerves—it’s the first time on set for many!), the project is starting to become a reality thanks to an incredible team that’s carefully telling this story with the scientific rigor it deserves.
#Reproduction #fertility #shortfilm

But… what is AMORE? Dr. María Climent and Dr. Raquel Pérez explain it 🎥🔬🩰

#Reproduction #Female #Embriology #ShortFilm

www.instagram.com/reel/DSxXWxS...

Empezamos…
(So exciting!)

Mitochondrial metabolism influences meiotic maturation in human oocytes of young and advanced maternal age women AbstractSTUDY QUESTION. Is there a relationship between the mitochondrial activity and the meiotic progression of oocytes from germinal vesicle (GV) to met

Could mitochondrial activity be the hidden driver of human oocyte ageing? 🔬

Human Reproduction, deaf207, doi.org/10.1093/humr...

#FertileAge #FemaleFertility #WomenBiology #Reproduction #Embryology #Oocyte

Today, Dr. María Climent, one of the project directors, presented the poster titled “Age-Related Epigenetic Remodeling in Mammalian Oocytes: High-Resolution Profiling of Histone Modifications” at the ASEBIR Congress 💪

#ASEBIR #XIIICongresoASEBIR

Pregnancy is linked to faster epigenetic aging in young women | PNAS A central prediction of evolutionary theory is that energy invested into reproduction comes at the expense of somatic maintenance and repair, accel...

Pregnancy leaves a mark🐾: New study shows pregnancy is linked to faster epigenetic aging in young women, supporting the evolutionary cost of reproduction hypothesis.

doi.org/10.1073/pnas...

#FertilityResearch #Reproductive #WomensHealth #Embriology #MaternalAge #epigenetic 🔬

Fathers shape embryonic development through molecular ‘signatures’. Credits: Daniela Velasco/EMBL

New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development.

These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...

Aging by the clock and yet without a program - Nature Aging Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

So well deserved!! So so happy for you!!! Juliane vales mucho!!!

🧪 A variant in the Jumonji cofactor Jarid2 – and thus in H3K27 methylation – is associated to compromised fertility in both humans and mice.
Another clue pointing to the role of #epigenetics in #fertility: rdcu.be/eD4S2

Did you know organ systems and organ apparatuses aren’t the same? An apparatus is a group of organs with similar functions but different origins (analogous). A system is a group of organs that share both function and embryonic origin (homologous).
#AnatomyFacts #EmbryologyInAction #DidYouKnowScience

This year I’ll try to also include some posts about how fascinating anatomy and embryology are — in both veterinary and human fields, since they share so many processes!
Let's try...

Here comes September and a brand-new 2025/2026 academic year — Let's get started!

Interesting!! (Apart from the eye-catching animation :) )

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

Figure 1 Schematics of extra-embryonic mesoderm development across species. (A) An intermediate stage of reptilian development displaying the vascularized trilaminar omphalopleure, also known as choriovitelline membrane, and the bilaminar omphalopleure. (B) A later developmental stage in squamates, showing a feature unique to squamates: the yolk cleft. The composition of the amnion, allantois and chorion is similar in all reptiles. (C) E1 (24 h) chick embryo showing the primitive streak, area vitellina and vasculosa. (D) E10 chick embryo displaying the localization of vascularized and non-vascularized extra-embryonic mesoderm (EXM) cells.

In this Review, @eliananehme.bsky.social, @amiteshp.bsky.social, Isabelle Migeotte and @pasquelab.bsky.social give an overview of the embryonic origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies.
journals.biologists.com/dev/article/...

Thank you Max!!! :)

Thank you Maud!

😃

Thank you Kasia!

Thanks!

Changing profile to:
Associate professor at @www.unizar.es ...
...
I got tenured!
... Looking forward to start new long-lasting scientific projects and collaborations! :)

H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨

📄 Check it out here:
doi.org/10.1101/2025...

👇 Highlights below

Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇

Hello Erik,
I am an assistant professor at the University of Zaragoza, and I work on the filed of epigenetic, embryology and aging. I would love to be added as a contributor, please :). My ORCID: orcid.org/0000-0001-86..., and google scholar: scholar.google.es/citations?us....
Thank you!

An RNA Splicing System that Excises Transposons from Animal mRNAs All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects C. elegans and human genes from DNA transposon-medi...

One of the coolest and most novel findings I’ve seen in years. This is why I work in worms. To find things no one even really knew to look for. Like a conserved system that splices transposons out of mRNAs to prevent otherwise lethal insertions in essential genes! - www.biorxiv.org/content/10.1...

Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness - Nature Cell Biology Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...

Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9

Artistic illustration of embryo patterning

How do cells find their place in a developing embryo? Scientists have long wondered. A new study by the Hiiragi group uncovers how embryos achieve precise cell organization. Curious what breadcrumbs have to do with this? @prachitimoghe.bsky.social explains it here: www.hubrecht.eu/breadcrumb-t...