Zhi Yu

The future is bright!💫 @mchonig.bsky.social @pnatarajanmd.bsky.social @zhiyu.bsky.social

Study finds that Non-DNMT3A CHIP was associated with CKD progression among individuals with CKD, and Tet2-CHIP mouse models support a causal role in kidney injury. https://bit.ly/JASN0680
@drflashheart.bsky.social
@pnatarajanmd.bsky.social
@zhiyu.bsky.social
#ASNJASN

In patients with CKD, non-DNMT3A CHIP was associated with cardiovascular disease with an effect size similar to that reported in the general population. https://bit.ly/JASN0671
#ASNJASN
@drflashheart.bsky.social
@pnatarajanmd.bsky.social
@zhiyu.bsky.social

Research suggests Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to CKD and its comorbidities, necessitating additional research. https://bit.ly/JASN0739
@drflashheart.bsky.social
@pnatarajanmd.bsky.social
@zhiyu.bsky.social
#ASNJASN

The SMaHT marker paper is now live in @nature.com 🧬

This landmark study characterizes somatic variation across 19 tissue types from 150 nondiseased donors, laying the groundwork for future discoveries in health, aging, and disease.

Read the full paper: www.nature.com/articles/s41...

The abstract deadline for "Mutations in Time and Space 2025" is in a week! Please register here: broadinstitute.swoogo.com/mits2025

Coancestry superposed on admixed populations yields measures of relatedness at individual-level resolution The admixture model is widely applied to estimate and interpret population structure among individuals. Here we consider a "standard admixture" model that assumes the admixed populations are unrelated...

Happy to share "super admixture", a new framework for modeling the human population structure!
www.biorxiv.org/content/10.1...

Terrific holiday party / “Yankee swap” 🎁🔄🎁 with @mchonig.bsky.social @zhiyu.bsky.social Fahed + @pnatarajanmd.bsky.social labs 🎅 🎄 @massgeneralbrigham.bsky.social MGB Heart + @broadinstitute.org @broadinstitute.bsky.social

HUGE congrats to @artschuermans.bsky.social for winning the 2024 @ukbiobank.bsky.social Early Career Researcher of the Year Award!!
Wonderful and bright visiting medical student with @mchonig.bsky.social & me @broadinstitute.org / MGH!!

Spread the word! Registration for the "Mutations in Time and Space" conference is open. The meeting is all about the origins, patterns, and consequences of mutations across cells, individuals, populations, species. Abstract submission deadline is Jan 17th broadinstitute.swoogo.com/mits2025/597...

Had an amazing time sharing our work 🧬 at UCSF/Gladstone and visiting other incredible schools across the Bay Area 🌞! Greatly enjoyed meeting with inspiring young PIs like @jamespirruccello.com, @amalaa.bsky.social, @diegoisworking.bsky.social, @shoaclarke.bsky.social and so many others : )

What does the circulating proteome teach us about common heart diseases?

Thrilled to share our analysis identifying new biomarkers, drug targets, and prediction models for these conditions.

Mentored (supremely) by @mchonig.bsky.social and @pnatarajanmd.bsky.social nature.com/articles/s44... (1/x)