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Michele Zanini

@mzaniniphysiology

Lecturer in Applied Exercise Science @ The Open University PhD @ Loughborough University Head of S&C and Physiologist @ Italian Triathlon Federation Applied Physiology, Endurance, Performance

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Latest posts by Michele Zanini @mzaniniphysiology

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Defining physiological resilience and durability in the context of endurance performance modeling | Journal of Applied Physiology | American Physiological Society

Together with Andy Jones and Lars Nybo, here is our brief view about:

- How Physiological Resilience and Durability should be distinguished

- How they link the abundant literature on fatigue development with endurance performance models.

journals.physiology.org/doi/full/10....

17.12.2025 16:37 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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🚨 Fully funded PhD 🚨
(UK & International)

Work with me at @openuniversity.bsky.social on Durability in endurance athletes πŸƒπŸ»β€β™€οΈπŸš΄πŸ½

πŸ”„ Please share

πŸ”¬Brand new lab facilities

Deadline: 16 Jan 2026

Start: Oct 2026

Details πŸ‘‰ wels.open.ac.uk/research/res...

πŸ’¬ Feel free to reach out for a chat

26.11.2025 18:16 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Nice work!

The durability of speed at LT was found to be moderately associated with marathon performance in trained runners πŸƒπŸ»

01.11.2025 14:54 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Regular Long Runs and Higher Training Volumes are... : Medicine & Science in Sports & Exercise rences in RE durability. Therefore, this study aimed to compare RE durability during a 90 min run and the decrements in neuromuscular capabilities, between athletes that did, or did not, practice regu...

7/7

This highlights the importance of training specificity (i.e. long runs) and higher mileage for sustaining economy during prolonged exercise – key for events from 10k to marathon.

πŸ”„ Share & discuss!

πŸ“„ Free full text (AoP): journals.lww.com/acsm-msse/ab...

29.08.2025 17:21 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

6/7

Take-home messages:

Even with identical performance levels, training matters for durability.

Runners regularly including long runs – and accumulating higher mileage – had:

βœ… More durable running economy
βœ… Smaller neuromuscular declines

29.08.2025 17:21 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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5/7

When we merged data from both groups, RE durability correlated:

πŸ“‰ strongly to weekly longest run (r=-0.67; p<0.001)

πŸ“‰ and moderately to weekly running distance (r=-0.48; p=0.038)

But not to declines in neuromuscular function.

29.08.2025 17:21 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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4/7

Neuromuscular function followed a similar trend:

🦡🏼 SDT showed larger drops in maximal squat force (-19% vs -12%)

⬆️ SDT lost CMJ performance (6.6%), while LDT maintained it

29.08.2025 17:21 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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3/7

During a 90 min run at LT:

- Running economy deteriorated nearly 50% less in LDT than SDT (+3.1% vs +6.0%)

- Differences emerged after 60min and grew with time

29.08.2025 17:21 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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2/7

We matched well-trained runners for 10k time (39 min), V̇O₂max (~58 ml/kg/min) & LT speed (12-13 km/h)

But differed in training characteristics:
- LDT: regularly running β‰₯90min
- SDT: always run <70min

LDT also ran more (51 vs 30 km/wk) & had better fresh running economy

29.08.2025 17:21 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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🚨 The last paper of my PhD is out in @MSSE

Regular Long Runs and Higher Training Volumes are Associated with Better Running Economy Durability in Performance Matched Well-Trained Male Runners

πŸ™πŸ» Rich Blagrove & Jonathan Folland

Temporary free download.

πŸ”— journals.lww.com/acsm-msse/ab...

🧡 1/7

29.08.2025 17:21 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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3rd place in the Young Investigator Award at @ecssofficial.bsky.social, presenting in front of 1500+ people.

β€œYou are here because you are excellent, and the quality of your research is excellent”.

Among the kindest words I’ve ever been told. As a young scientist, they mean the world πŸ™πŸΌ

Ad maiora.

07.07.2025 16:56 πŸ‘ 6 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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This Tuesday I will give an oral presentation at the @ecssofficial.bsky.social annual congress in Rimini about:

The effect of 90 and 120 min of running on the determinants of endurance performance in well-trained male marathoners

01.07.2025, 14.30

29.06.2025 07:57 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

5/5

❗️Final message

Researchers should consider, quantify, and report TL.

If you’re assessing training interventions, matching TL may help ensuring results reflect their effect, without being confounded by unintended differences in the dose of training prescribed.

24.06.2025 08:19 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

4/5

We also highlight why TL matching might not be essential. For instance when:

- Studying real-world training programmes

- Investigating outcomes less sensitive to dose (like enjoyment or adherence).

24.06.2025 08:19 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

3/5

Our paper explores how TL mismatches can skew results, and when matching TL is likely beneficial.

We provide 3 practical examples in areas where TL warrants consideration.

And briefly discuss how an increased TL carries differences depending on participants characteristics

24.06.2025 08:19 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

2/5

Training load (TL) can be associated to the "dose" of exercise.

When groups in a study receive different doses, it becomes unclear whether the outcomes are due to the type of training, or simply more training.

An issue for interpreting effectiveness in some contexts.

24.06.2025 08:19 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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πŸ“£ New paper out in European Journal of Applied Physiology

We discuss an often-overlooked aspect in sports science and rehab research:

The importance of matching training load across interventions.

Nice collaboration led by Tomek Kowalski.

πŸ“„ Open access
πŸ”— link.springer.com/article/10.1...

🧡1/5

24.06.2025 08:19 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Test–Retest Reliability of Running Economy and Other Physiological Parameters During 90 min of Running in Well‐Trained Male Endurance Runners Running economy (RE) is highly reliable when measured in an unfatigued state; however, its reproducibility during prolonged exercise has not been investigated. RE is known to worsen during prolonged ...

8/8

‼️Results matter for durability studies assessing interventions & longitudinal athlete profiling.

πŸ”‘ Finding: Even subtle differences in RE durability between conditions are likely detectable.

πŸ” Share if you find this interesting.

πŸ†“ Open access
πŸ“„ onlinelibrary.wiley.com/doi/10.1111/...

27.05.2025 12:40 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

7/8

Summary:

βœ… RE (expressed as OC or EC) is reliable during prolonged running
βœ… VE, RER, and HR also consistent
⚠️ BLa and RPE less so, esp. >60 min

4/5 PhD studies published. As always thanks to Rich Blagrove and Jonathan Folland.

27.05.2025 12:40 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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6/8

Blood lactate (BLa) was the least reliable:
β€¨πŸ”Ή ICC = 0.48–0.94β€¨πŸ”Ή CV = 5–16%

Reliability dropped after 60 min.

This likely reflects limits in analyser precision more than physiology.
Caution warranted when interpreting small BLa changes during prolonged exercise!

27.05.2025 12:40 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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5/8

RPE was moderately reliable, with:

πŸ”Ή ICCs = 0.41–0.72β€¨πŸ”Ή CV = 4.2–6.0%
No effect of time on CV – fatigue didn’t make it less reliable.

Important: subjectivity means RPE isn’t as stable as physiological data.

27.05.2025 12:40 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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4/8

Heart rate (HR) was also highly reliable:

πŸ”Ή ICCs = 0.82–0.92β€¨πŸ”Ή CV = ~1.1%β€¨πŸ”» Slightly lower in trial 2 at later timepoints; possibly due to familiarisation.

Still well within typical day-to-day HR variability.

27.05.2025 12:40 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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3/8

Ventilation (VE) and RER also showed strong reliability:
β€¨πŸ”Ή VE: ICC = 0.96–0.97, CV < 3.6%β€¨πŸ”Ή RER: ICC = 0.78, TE ≀ 1.9%

These markers are consistent across 90 min of heavy-intensity running.

27.05.2025 12:40 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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2/8

Both Energy Cost (EC) and Oxygen Cost (OC) showed excellent reliability across all timepoints:
β€¨βœ… ICCs: 0.96–0.99β€¨βœ… CVs: 0.6%–1.2%β€¨βœ… TE: ≀1.4%

No decline in reliability over time.

‼️RE durability is measurable and trustworthy.

27.05.2025 12:40 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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New paper out in Scand J Med Sci Sports!

We tested the reliability of running economy (RE) and other physiological parameters during 90 min of running.β€¨β€¨βž‘οΈ Running economy is highly reliable in a fatigued state, a πŸ‘πŸΌ implication for testing durability

πŸ†“πŸ“„ onlinelibrary.wiley.com/doi/10.1111/...

🧡1/8

27.05.2025 12:40 πŸ‘ 8 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0

I think a possible solution could be having a testing session as an outdoor long run with pre-post assessment of running economy and speed at LT (this could be done on a separate day).

sLT is likely to capture multiple changes under a single variable, and testing it may not be too intense.

21.05.2025 14:29 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thank you Jamie!

I think a thorough durability testing for high-level marathon is quite challenging - as you already pointed out. Athletes more trained than our cohort will likely display smaller changes, so either duration or intensity would need to increase..

21.05.2025 14:29 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

πŸ” If you're a practitioner, coach, athlete, or scientist interested in endurance performance, feel free to share this thread.

πŸ†“ Open-Access
πŸ“„ onlinelibrary.wiley.com/doi/10.1111/...

14/14

19.05.2025 09:15 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks to the runners who pushed through these VERY demanding trials.

πŸ™ Grateful to my PhD supervisors Rich Blagrove and Jonathan Folland.

Future directions may include:

πŸƒπŸ» Training intervention studies
🏁 Marathon performance modelling which includes durability.

13/14

19.05.2025 09:15 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Take-home message:

βœ… VΜ‡Oβ‚‚peak and sLT decline non-linearly, particularly between 90 and 120 min
βœ… RE deteriorates steadily
βœ… FULT increased due to VOβ‚‚max drop

πŸ’₯ Pacing, race modelling & training may need to account for durability.

πŸ“„ onlinelibrary.wiley.com/doi/10.1111/...

12/14

19.05.2025 09:15 πŸ‘ 2 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0