🧠New preprint: Neurodegeneration-associated proteinopathies are not confined to the brain, they can be detected in routine GI biopsies, years before symptom onset.
16.10.2025 09:19
👍 0
🔁 0
💬 0
📌 0
🧠New preprint: Neurodegeneration-associated proteinopathies are not confined to the brain, they can be detected in routine GI biopsies, years before symptom onset.
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.10.13.25337884v1
🧠New preprint: Neurodegeneration-associated proteinopathies are not confined to the brain, they can be detected in routine GI biopsies, years before symptom onset.
www.medrxiv.org/content/10.1...
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset https://www.medrxiv.org/content/10.1101/2025.10.13.25337884v1
#Medsky🧪 #neurosky #immunosky Studies are investigating a link between #proteinmisfolding in GIT & the development of #neurodegenerativediseases like #Parkinson & #Alzheimer often years before symptoms appear.
Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis https://www.biorxiv.org/content/10.1101/2025.10.02.680028v1
Prof. Jenna Gregory @uniofaberdeen.bsky.social
outlines some precision-prevention concepts for #MND
🤔Detection>Before motor symptoms arise
🤔Precision>Understanding individual’s risk factors & heterogenous disease manifestations
🤔Prevention>Safe interventions & early triage to clinical trials🧵3/3
Unlike cancer, which is often diagnosed early in the community #MND is typically diagnosed in late stages in the outpatient setting. Prof. Jenna Gregory from @uniofaberdeen.bsky.social highlighted the need for early detection with point-of-care assays. 🧵2/3
At LifeArc's recent 1st ever Translational Science Summit on MND & Rare Dementias, Clinical Prof. Jenna Gregory
from @uniofaberdeen.bsky.social set out a vision for early diagnosis & prevention in #MND #ALS through learning from cancer, early detection tools, & a focus on prevention 🧵1/3
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
Many thanks for the post - I am also recruiting for a postdoctoral Research Associate post in complex Human Organoid-based ALS disease modelling: www.jobs.cam.ac.uk/job/49564/