Kira Höffler

Writing your PhD thesis in a windowless office with no daylight is not for the weak.

I had the opportunity to present my PhD research at the Norwegian Institute of Public Health in Oslo today :)

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling - Nature Genetics Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism...

Out earlier this week in @natgenet.nature.com: GWAS of major anxiety disorders in 122,341 European-ancestry cases identifying 58 loci (www.nature.com/articles/s41...)

Awesome work, and great news for the anx genetics community — each @pgcgenetics.bsky.social paper seeds 100s more papers!

thank you😊

Happy and thankful for this award!☺️

cool! I put it on my reading list:)

ECNP Roadmap Meeting on Precision Psychiatry 2026

The #ECNP Roadmap Meeting on #PrecisionPsychiatry wrapped up yesterday ✨

Experts across science, clinical practice, regulation, industry & patient advocacy explored how to move #biomarkers from research to real‑world impact 🔍
Inspiring discussions and clear next steps 🚀
www.ecnp.eu/roadmap-meeting

congratulations 👏

🥁🎇✨ ... first up is KIRA HÖFFLER @kirahoeffler.bsky.social from the #UniversityofBergen in Norway and #McLeanHospital in Boston ! So tell us, Kira, what do you do in #functionalgenomics and @pgc_fg ?🤔 Any #funfacts #genetics 🐝❓
🧵3/3

Four pivotal ages in your brain's development revealed in new scientific study Brain scans on thousands of people reveal the dramatic shifts the brain goes through between birth and death.

The human brain goes through distinct phases in life, with turning points at ages 9, 32, 66 & 83, scientists have revealed.

~4,000 people up to the age of 90 had scans to reveal the connections between their brain cells.

We "peak" in our early 30s ...

🧪🧠 #neuroskyence
www.bbc.com/news/article...

Congratulations @robertau.bsky.social 😊

✨Hello folks!✨

We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦

"Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches"

🔗http://bit.ly/49syndi

Read our overview below!

🧵1/6

Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches - Epigenetics & Chromatin Background Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs)...

New method for DNA methylation studies 🧬:
EpiAnceR+ improves ancestry adjustment without requiring genotyping data, while removing technical and biological noise. Easy to use in existing R pipelines.
link.springer.com/article/10.1...

Curious whether response to psychotherapy in OCD can be predicted using clinical and DNA methylation data? Come see Poster 1️⃣ at #WCPG2025. I’ll be presenting our first machine learning findings!

🙌

Back at my favourite conference #WCPG2025 - this time in a slightly different setting (an all-inclusive beach hotel) #cancun #mexico @ispg.bsky.social

The Biological Psychiatry family of journals is now officially on Bluesky!

Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.

cool findings!

Inspiring AI Cures Conference at MIT with stunning views of beautiful Boston.

A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison - Nature Mental Health The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesti...

www.nature.com/articles/s44...

cool!

🙌 congratulations

I find it somewhat disappointing that medRxiv does not accommodate the use of the "ö" in my surname and instead only allows the internationalized spelling.

Dieses Spiel werden die Beteiligten und Fans vorm Fernseher so schnell nicht vergessen. Drei Stunden komplett aufreibender Fußball. #FRAGER

After more than 7 years working on it, I’ve just submitted the manuscript for Discovering Statistics using R second edition. Tonnes more work on website/package and so on, but getting to this stage is monumental psychologically. It’s the book I feared I’d never finish.

Und ich dachte bislang immer, #CSD und #Regenbogenfahnen stünden für die demokratische Tradition der Kämpfe um Anerkennung jener Rechte, die letztlich das Grundgesetz allen verspricht: Freiheit und Gleichheit und Unantastbarkeit der Würde.

I got to meet Jacinda Ardern, my favourite politician and former Prime Minister of New Zealand, today. Just for that, moving to Boston was worth it. 😊

Vielen lieben Dank!

Gender equality in research publishing is a responsibility for everyone A concerted effort is needed to support women in their choice of journal when submitting their manuscript.

Women make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40% #womeninSTEM

We want to change it, through targeted editorial policies & outreach. But change will take everyone!
🧪
www.nature.com/articles/d41...