Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
Molecular insights into bulk lipid transport from structural studies of the bridge-like protein VPS13A complexed with the scramblase XKR1 www.biorxiv.org/content/10.6...
Congrats, Tara!
Ruh-roh
Fantastic!
Very very cool! If you are ever interested in talking about BLTPs, I'd love to chat
Fantastic work!
Fantastic new work revealing mechanisms of pro-apoptotic signaling as a result of lysosomal dysfunction and subsequent DNA damage.
In natural systems, form often determines function. Check out how this model of BLTP3A exhibits the tube-like form that allows it to bridge membranes, and how its partner protein, LC3, docked here near the C-terminus, can serve to orient BLTP3A towards its intended site of action/lipid delivery.
We’re located at Penn State University in lovely State College, PA.
More info about the research focus of the lab can be found here: sites.psu.edu/hannalab/
The Hanna lab is looking for an enthusiastic Research Technologist to join the team! 😊
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
Recent @yale.edu research led by @adwolfe.bsky.social, Milind Singh & @dacolon.bsky.social reveals neurons' ability to store glycogen as a backup fuel ⛽️, keeping the brain running under stress — a process called “glycogen-dependent glycolytic plasticity” (GDGP).
🚨 We’re hiring a postdoc! 🚨
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: luis.bonetponce@osumc.edu
Learn more: bonetponcelab.com
Let’s chat!
The Hanna lab has a website! 🖥️
Come check it out to see what we’ll be up to 😁
sites.psu.edu/hannalab
Congrats on the fantastic work!
Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!
How delivery of new membrane lipids to lysosomes may limit or even repair damage remains unclear. This is a big emphasis for my future work!
Loss of BLTP3A leads to increased lysosome fragility. Our working hypothesis is that CASM recruits BLTP3A to transfer lipids to damaged lysosomes in participation with other lipid transfer proteins.
We find that BLTP3A, a lipid transfer protein structurally related to VPS13 and ATG2 proteins, plays a role in the response to lysosome damage as an effector of the CASM (conjugation of ATG8 to single membranes) pathway
First, a special shout out to @helyrodriguez.bsky.social – a fantastic scientist who put in a tremendous effort on this manuscript
New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social
@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...
A headshot of Ben Johnson, on a light blue background with dark blue text reading “Ben Johnson, PhD, De Camilli.” The "Open Science Champion" badge and ASAP logo are also present.
👏 We’re recognizing Ben Johnson (CRN Team De Camilli) as this month’s Open Science Champion!
Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben!
Check out the manual: bit.ly/46DuL6R
Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs
Thrilled to share that I’m starting my lab in the Department of Neuroscience at the University of Florida! We’ll study metabolism in brain aging to better understand Alzheimer’s disease. Excited to build, collab, and discover. Go Gators! 🐊
#Neuro #Aging #Alzheimers #UF
ufresearch.bsky.social
In a time as this— I am deeply thankful to be blessed with this honor. As a scientist and educator, the NSF CAREER award allows me to integrate the very core of who I am as a scientist and educator.
Forever grateful to past and present members of my lab for helping me accomplish this dream.
One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
Beautiful preprint from @aguillensamander.bsky.social who uncovered an essential role for a bridge-like lipid transfer protein (PfVPS13L1) on the growth of the inner membrane complex (IMC) in P. falciparum parasites: www.biorxiv.org/content/10.1...
Congrats, Anup!
