YC Chu

Images showing how expressing human Tau in the Drosophila wing reduces the size of the posterior compartment. Panels include: a schematic of larval and adult wings highlighting the posterior region; fluorescent wing discs expressing control mCD8::Cherry or mCherry‑tagged human Tau with E‑cadherin staining; quantification plots comparing posterior/anterior size ratios; and adult wings with the posterior compartment outlined, demonstrating that Tau isoforms 0N4R and 2N4R significantly shrink this region.

@miguelrmphd.bsky.social, Douglas Watt Allan, Amritpal Mudher & co model Tau-induced neurotoxicity in the #Drosophila wing, enabling a rapid, genetically tractable in vivo system for #tauopathies studies.

Read doi.org/10.1242/dmm....

@sotonbiosciences.bsky.social @unisouthampton.bsky.social

These brain cells clear proteins that contribute to Alzheimer’s When specialized cells called tanycytes stop working, disease-causing tau proteins build up in the brain.

When specialized cells called tanycytes stop working, disease-causing tau proteins build up in the brain.

go.nature.com/4ldhrez

Design of the protein FRET ladder

Fancy a fresh preprint for Friday? When we were first getting involved with single molecule FRET, there weren't any standard protein molecules that suited our applications to help us develop our pipeline. So we built some! A universal protein ladder for FRET. 🧵 1/

Flexible paths to multicellularity Close relatives of animals can become multicellular if distinct individuals join together or if dividing cells remain attached. A species has been found to use both mechanisms.

This species can become multicellular using two mechanisms previously thought to be mutually exclusive

go.nature.com/4aTKdfF

Vectorized instructive signals in cortical dendrites - Nature Mice learning a neurofeedback brain–computer interface task show neuron-specific teaching signals in cortical dendrites, consistent with a vectorized solution for credit assignment in the brain.

This paper on how the brain may do gradient descent is very cool: www.nature.com/articles/s41...

JCS Cover: The image shows human induced pluripotent stem cell-derived neurons immunostained for LAMP2 (red) and the neuronal marker TUJ1 (blue) and expressing LAMP1–EGFP (green; detected by anti-GFP immunostaining). LAMP1 and LAMP2 are members of the same protein family and are commonly used interchangeably to label lysosome-like organelles. However, new findings indicate that they localise to functionally distinct organelles, and this image highlights the heterogeneity of the neuronal endolysosomal system. See article by R. Abouward et al. (jcs264466).

Issue 3 is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

On the cover: hiPSC-derived neurons labelled with TUJ1 (blue), LAMP1 (green) & LAMP2 (red). The image highlights the heterogeneity of the neuronal endolysosomal system.
journals.biologists.com/jcs/article/...

Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate - Nature The choanoflagellate Choanoeca flexa forms motile and contractile cell monolayers purely clonally, purely aggregatively or through a combination of both processes depending on environmental condi...

Salinity tunes mode of multicellularity in a tidepool choanoflagellate www.nature.com/articles/s41... - paper in @nature.com

JAMA viewpoint article published online January 22, 2026, titled "Blood-Based Biomarkers for Alzheimer Disease Preventing Unintended Consequences" by Heather E. Whitson, Nicole R. Fowler, and Michelle M. Mielke.

💬 Viewpoint: FDA-cleared blood tests for #AlzheimerDisease improve diagnostic access but may lead to misdiagnosis, disparities, and legal or psychological harms without careful risk mitigation.

ja.ma/4sdBT1r

Comparative lung images from BALB/c mice infected with different MAC isolates, showing varying degrees of tissue damage. Representative lung slices display inflammation (in green) and granulomas (in red), with MAC101 and MAC104 infections showing larger affected areas than MAC2285R. Multi‑scale panels include whole‑lung views and higher‑magnification sections highlighting lesion severity and distribution.

Timothy Shaw, Mercedes Gonzalez-Juarrero & co investigated Mycobacterium avium complex isolate-dependent differences in #PulmonaryDisease, quantified them and added novel insights into #lung immune cell profiling and whole-body plethysmography in prolonged infection.

Read doi.org/10.1242/dmm....

Excited to share our work enabling imaging across scales, from molecular assemblies at a few hundred nanometers to living organisms and tissues at millimeter scale, with minutes time resolution.
www.biorxiv.org/content/10.6...

Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...

The most sensitive green and red #norepinephrine #sensors engineered to date are out in #naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @erc.europa.eu @snsf.ch doi.org/10.1038/s415...

The figure shows staining of mouse embryos with X-gal to highlight Ttc21b in whole-mount embryos (panels A-D,H) or after sectioning (panels E-G,I-N). Boxed areas in panel E are shown magnified in panels F and G, boxed areas in panels I and L are shown magnified in panels J and M. Arrows indicate specific areas of lacZ expression.

Rebekah Niewoehner, Rolf Stottmann & co found that pathogenic Ttc21b variants, the primary #cilia gene, contribute to primary #microcephaly, with homozygous #mouse mutants showing severe #microcephaly due to impaired neural progenitor proliferation and differentiation.

Read doi.org/10.1242/dmm....

A amazing new story by @cate-cholamine.bsky.social led by @forrestdrogers.bsky.social on the environmental modulation of paternal behavior in African striped mice, with a newly discovered molecular player of parental control, Agouti! Terrific study, congrats to all authors!...

Liver exercise factor GPLD1 rejuvenates blood-brain barrier integrity and reverses cognitive impairments in aging and Alzheimer’s disease models by targeting GPI-anchored proteins on brain endothelial cells @cellcellpress.bsky.social @ucsfaging.bsky.social
www.cell.com/cell/fulltex...

Congratulations @ivaskalab.bsky.social team for this study on the role of vibration in vocal cord cancer! Was a fun collaboration 🎤🎤

Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization Pathogenic Bordetella bacteria use protein adhesins to infect the ciliated respiratory epithelia of vertebrate hosts. In this work, we show that the filamentous hemagglutinin FhaB adhesin of Bordetell...

Just published in @science.org with related Perspective by Françoise Jacob-Dubuisson.
Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization | Science www.science.org/doi/10.1126/...

Monocyte-derived IL-10 drives sex differences in pain duration Peripheral monocytes and IL-10 are associated with shorter pain duration in males in both mice and humans.

Sex differences in pain duration
Finding interleukin-10 from monocytes as an/the explanation (in the experimental model and people
www.science.org/doi/10.1126/...

Cover: Immunofluorescence staining of phosphorylated FGFR1 (magenta), TBXT (yellow) and β-catenin (cyan) in 2D human gastruloids. The spatial pattern of phosphorylated FGFR1 matches ERK activity observed during primitive streak-like differentiation. See Research Article by Jo, Liu et al. (dev205459).

Issue 3 is complete!

On the cover: Immunofluorescence staining of phosphorylated FGFR1 (magenta), TBXT (yellow) and β-catenin (cyan) in 2D human gastruloids.

See the Research Article by Idse Heemskerk and colleagues (@heemskerklab.bsky.social) here: doi.org/10.1242/dev....

Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses Du et al. identify TBK1 as a natural asparagine sensor linking host nutritional homeostasis to innate immune responses. Asparagine binding induces TBK1 phase separation and subsequent activation. Viruses deplete asparagine to evade host immune defenses, suggesting that targeting asparagine availability may offer a therapeutic strategy for infectious diseases.

Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses

Fgf signaling inhibitor downregulates mmp1 expression in the articular cartilage during joint regeneration.

#DBfeature 🐸

Reintegration of blastema and stump by reciprocal interaction for functional joint regeneration in frogs

Fgf-mmp1 axis▶️ cell proliferation

by Haruka Matsubara, Takeshi Inoue, Kiyokazu Agata
www.sciencedirect.com/science/arti...

New lab paper in #ScienceAdvances: we identify a modality-common selective-attention signal in noncholinergic #BasalForebrain (BF) “bursting” neurons, distinct from the modality-specific attention signals typically described in corticothalamic circuits. 1/n
www.science.org/doi/full/10....

Biologically active mediators released from mast cells at baseline or after activation can trigger clinically relevant symptoms, which have been observed in all subtypes of mastocytosis
http://dlvr.it/TR4d10

Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - Nature In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.

More hope from mRNA vaccines. In this instance, individualized vaccines were given to women with triple negative breast cancer following surgery and adjuvant therapy. The results are quite remarkable. Despite cancer finding a ‘T cell-evading’ work-around in some patients.
#Science 🧪

Gene editing treats a mouse model of a neurodevelopmental disorder An approach that specifically targets a single nucleotide corrected behavioural abnormalities in an animal model of Snijders Blok–Campeau syndrome.

This gene editing approach specifically targets a single nucleotide corrected behavioural abnormalities in an animal model of Snijders Blok–Campeau syndrome

go.nature.com/40j3rX3

This ‘fundamental’ study shows that the α-tubulin tail is exposed more or less depending on the microtubule lattice state, influencing how microtubules interact with binding proteins and undergo chemical modifications.

🔗 buff.ly/dLncjnM

Are obesity drugs causing a severe complication? What the science says The United Kingdom and Brazil have issued warnings about a possible link between GLP-1 weight-loss drugs and pancreatic inflammation, but the connection is murky.

The potent GLP-1 drugs are taken by millions of people worldwide to counter obesity, diabetes and more. However, a rare and potentially fatal illness that might be linked to these blockbuster therapies is now causing alarm in some countries.


go.nature.com/4kLBj8D

Innovative CAR-T therapy destroys cancer cells without dangerous side effects In mice, the treatment selectively targets tumour cells without suppressing the immune system.

A new generation of engineered immune cell destroys cancer cells in mice as effectively as conventional CAR-T-cell therapies without suppressing the immune system

go.nature.com/4t9KIKO

Cholinergic modulation of dopamine release drives effortful behaviour - Nature In the nucleus accumbens, acetylcholine boosts dopamine release to promote effortful behaviour.

Nature research paper: Cholinergic modulation of dopamine release drives effortful behaviour

go.nature.com/4q0lpbf

Dopamine’s secret agent: serotonin Dopamine suppresses GABA release from striatal terminals in the substantia nigra pars reticulata. Molinari et al. recently demonstrated that this suppression is frequency-dependent—instituting a high-...

Happy to share this Spotlight article, drawing attention to recent work by @borgkvistlab.bsky.social on the mechanisms of dopamine action in the SNr.

Read our summary and then read their paper! Many cool implications!
@cp-trendsneuro.bsky.social

www.cell.com/trends/neuro...

Vagal blood volume receptors compensate for haemorrhage and posture change - Nature A vagal reflex to blood volume changes in the heart involves PIEZO2 and helps to stabilize blood pressure in an upright posture and after blood loss.

Nature research paper: Vagal blood volume receptors compensate for haemorrhage and posture change

go.nature.com/4a86eHn