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Argyris Zardilis

@zardilis

Scientist @slcuplants.bsky.social I like to wonder (το θαυμάζειν) about the world https://www.slcu.cam.ac.uk/people/argyris-zardilis

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08.02.2024
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Latest posts by Argyris Zardilis @zardilis

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Gene regulatory networks: from correlative models to causal explanations Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations"

Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations?

rdcu.be/e7zx7

09.03.2026 11:30 👍 109 🔁 42 💬 2 📌 2
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📢We are excited to announce the Cambridge Morphogenesis Symposium - a full day event at SLCU @slcuplants.bsky.social (and virtually) on 5 June 2026!
🎉Come celebrate the 5th anniversary of the seminar series!
🚩Register & submit abstracts by 3 April! Check out the details: t.ly/YYM3u
Please repost!🙏

09.03.2026 09:17 👍 24 🔁 20 💬 1 📌 1
Sainsbury Laboratory Symposium 2026 logo - Shaping Life-Mechanisms of Morphogenesis. Timelapse of a developing Arabidopsis leaf imaged at 9-12 days old under a confocal microscope, with cells segmented and coloured using MorphographX software. Images by Sarah Attrill.

Sainsbury Laboratory Symposium 2026 logo - Shaping Life-Mechanisms of Morphogenesis. Timelapse of a developing Arabidopsis leaf imaged at 9-12 days old under a confocal microscope, with cells segmented and coloured using MorphographX software. Images by Sarah Attrill.

Registrations now open for #SLS26 Sainsbury Laboratory Symposium 2026 in Cambridge, UK — Shaping Life: Mechanisms of Morphogenesis!
Join us explore how cellular, genetic & mechanical forces sculpt plant form
📅 22–24 Sept 2026
In-person + livestream
Limited fee waivers
www.slcu.cam.ac.uk/sls
#plantsi

16.02.2026 12:17 👍 40 🔁 28 💬 0 📌 3
Portail Emploi CNRS - Offre d'emploi - PhD (M/F) in development of machine learning methods for single-cell omics data integration Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler

PhD position in my team at @pasteur.fr ! The selected canddiate will work on the development of new methods combining biophysicial and machine learning modelling for single-cell multi-omics spatiotemporal data.

emploi.cnrs.fr/Offres/Docto...

30.01.2026 09:28 👍 10 🔁 12 💬 1 📌 0
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The Cambridge Morphogenesis Seminar Series is back! 🎉
Check out the flyer for a great lineup of speakers for Lent Term 2026!
Don't forget to subscribe to our mailing list to get all the information, including the Zoom link. We are excited to see you again soon 👋

16.01.2026 14:38 👍 15 🔁 8 💬 1 📌 2

We have an open PhD position here in Marseille - please spread the word :)
Deadline for application is 28th of January!

07.01.2026 12:43 👍 6 🔁 4 💬 0 📌 1
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The new ShapeEmbed deep learning method helps quantify shapes in bioimages 🔬

It learns to encode 2D object outlines into descriptors that are invariant to several geometric transformations.

Great for robust cell shape analysis, classification & exploring phenotypes.

neurips.cc/virtual/2025...

18.12.2025 08:56 👍 16 🔁 4 💬 1 📌 0
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Investigating morphogen and patterning dynamics with optogenetic control of morphogen production Benzinger et al. develop a chemo-optogenetic system for precise spatiotemporal control of morphogen production in vitro. Using light-controlled Sonic hedgehog expression, they recapitulate neural tube...

Good to see the peer reviewed version of this published

A chemo-optogenetic system for spatiotemporal control of gene expression

We use it to:

- Reconstruct SHH mediated neural tube patterning in vitro

- Measure extracellular half-life of Shh

www.cell.com/developmenta...

16.12.2025 01:45 👍 71 🔁 24 💬 3 📌 0

Interested in doing an interdisciplinary PhD to elucidate signalling centres that orchestrates limb regeneration? Come to work with the amazing @canaztekin.bsky.social and myself!!

17.12.2025 08:40 👍 3 🔁 2 💬 0 📌 0

Congratulations Elise Laruelle & @robinsonsci.bsky.social on your @acceleratescience.bsky.social - @c2d3.cam.ac.uk funded project "Plant automatic cell lineage reconstruction"
More info www.slcu.cam.ac.uk/news/plant-a...
Illustration by Elise Laruelle & leaf images by @sainikumud.bsky.social

28.11.2025 13:44 👍 21 🔁 8 💬 0 📌 1
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Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...

Our work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al.

Paper: www.nature.com/articles/s41...

13.11.2025 13:08 👍 48 🔁 25 💬 1 📌 4
advert text as bitmap

advert text as bitmap

picture of the Schornacklab team

picture of the Schornacklab team

Plz RP. Come join us at @slcuplants.bsky.social @cam.ac.uk to study effector-targeted plant processes impacting plant cell biology and development.
www.cam.ac.uk/jobs/post-do...
www.schornacklab.net

06.11.2025 18:51 👍 33 🔁 38 💬 0 📌 1
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How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework?

We propose to think along Marr's 3 levels: computational problem, algorithm, implementation

Check out our review:
arxiv.org/abs/2510.24536

10.11.2025 06:46 👍 49 🔁 13 💬 1 📌 2
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The Cambridge Morphogenesis Seminar Series is back this Michaelmas Term 2025!
Join us for an exciting lineup of talks exploring the many facets of tissue morphogenesis. Check out the flyer for the full list of speakers!

03.10.2025 08:02 👍 9 🔁 4 💬 1 📌 0
CBIAS2025 flier, showing the conference logo, listing the topics, confirmed speakers and sponsors. On the top right corner, a QR code is available to access the registration page.

CBIAS2025 flier, showing the conference logo, listing the topics, confirmed speakers and sponsors. On the top right corner, a QR code is available to access the registration page.

The program for the #CBIAS2025 is now live – space is limited, so register now to secure your spot! 24th-25th Nov, Wellcome Trust, London (UK) - see you there!

🔗⬇️
www.crick.ac.uk/whats-on/cri...

23.09.2025 13:13 👍 10 🔁 7 💬 0 📌 0

New preprint!
"Understanding Shape and Residual Stress Dynamics in Rod-Like Plant Organs" 🌱
with @merozlab.bsky.social and @routierlab.bsky.social
👉 doi.org/10.1101/2025...

29.08.2025 07:51 👍 14 🔁 6 💬 1 📌 0
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The BM^2 Lab is hiring a Ph.D. student to work on a variety of problems connected to modeling of morphogenesis in plants (i.e. ovule curvature formation, fixed handedness establishment in certain plant organs and its link to cell wall mechanics).

Please share!

07.09.2025 08:44 👍 34 🔁 39 💬 1 📌 2
Group photo of workshop attendees standing in ginkgo tree courtyard with the Sainsbury Laboratory Cambridge University building in background.

Group photo of workshop attendees standing in ginkgo tree courtyard with the Sainsbury Laboratory Cambridge University building in background.

🌿💻 Plant Models and Morphology 💻🌿

The 9th International Plant Computational Biology Workshop @slcuplants.bsky.social brought together mathematicians, computer scientists, physicists and biologists exploring plant development through models and simulations.

Huge thanks to organisers and speakers!👏

17.09.2025 12:02 👍 18 🔁 4 💬 1 📌 0
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Very happy to share MODIS - a new Multi-Omics Data Integration method for Small and unpaired datasets!

We solve a long-standing problem in the field: how to perform data integration for small unpaired datasets

Our solution: learning with class imbalance on both reference and target datasets!

16.09.2025 10:33 👍 13 🔁 2 💬 1 📌 0

Amazing illustration @nickdesnoyer.bsky.social 🌺!
I wish we had something like this to illustrate the dynamics of our model!

Paper (including model, not animated sadly!)
➡️ doi.org/10.1126/scia...

16.09.2025 16:03 👍 3 🔁 0 💬 0 📌 0
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Home - RESYDE: Re-engineering symmetry breaking in development and evolution. A consortia of plant scientists from Europe and Australia has been awarded a prestigious research grant from the ERC, which will ...

Come and work with us!
We are hiring a research assistant/associate @slcuplants.bsky.social to work on the RESYDE project (www2.hu-berlin.de/resyde/)
using ML for multi-scale data and modelling to understand and engineer flower development!

Details: www.jobs.cam.ac.uk/job/52116/

23.07.2025 12:16 👍 7 🔁 5 💬 0 📌 0
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It was very nice to attend and present at #LMRL @iclr-conf.bsky.social !

Our paper with my student Sasha Budnikova @slcuplants.bsky.social on learning mechanical models (Lockhart) from data!
openreview.net/forum?id=yQF...

02.05.2025 07:04 👍 1 🔁 0 💬 0 📌 0

Looking forward to this! Join us!

10.04.2025 11:01 👍 1 🔁 0 💬 0 📌 0
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A computational pipeline for spatial mechano-transcriptomics - Nature Methods The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.

🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...

17.03.2025 12:52 👍 139 🔁 53 💬 10 📌 3
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We were delighted to host @zardilis.bsky.social from Cambridge's Sainsbury Laboratory during the past two weeks! It was a fantastic opportunity to exchange ideas on the spatial biology of plants and beyond. Interesting new methods combining expression patterns, morphometric and physical features!!

25.11.2024 10:28 👍 9 🔁 3 💬 1 📌 0

Thanks Paul! Back in Cambridge full of ideas!

25.11.2024 13:05 👍 1 🔁 0 💬 0 📌 0