Jonas Van lent

🚀 We’re growing! Are you passionate about human pluripotent stem cells? We are looking for 1 PhD student + 1 Lab technician to join us ☀️

ior.usi.ch/institute/jobs

PIEZO channels link mechanical forces to uterine contractions in parturition Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...

New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...

BOOM! Cool to see the final form of this great work now published. Deep new insight into human peripheral neuropathy. Congrats @mheming.bsky.social and colleagues on a great study.

Expansion microscopy reveals nano-scale insights into the human neuromuscular junction Ramadan et al. employ expansion microscopy to visualize neuromuscular junctions in human and mouse muscles. Their findings demonstrate expansion microscopy as an accessible and cost-effective approach...

New paper from the lab 🚨: Expansion microscopy reveals nano-scale insights into the human neuromuscular junction: Cell Reports Methods www.cell.com/cell-reports...

🚨 Exciting opportunity to join us! 👇

🚨 Exciting opportunity to join our lab 👇

Thank you so much Arianna! 😊🧬

Congrats to our brilliant postdoc🥳, @jonasvanlent.bsky.social, on receiving the Young Investigator Award from the Children’s Tumor Foundation! This recognition is a statement to the impact of your important research🌟!. We’re excited to follow your journey and see how you’ll advance science💪🌟

#IORnews
Jonas Van Lent receives the Children's Tumor Foundation's Young Investigator Award. Congrats @jonasvanlent.bsky.social !

Read more: shorturl.at/ObLS5

Retromer promotes the lysosomal turnover of mtDNA Lysosomal uptake of mtDNA controls mitochondrial quality.

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵

www.science.org/doi/10.1126/...

Check out this brief overview of human stem cell models and their promise in the @thetransmitter.org.web.brid.gy

#hipscells #stemcells #organoids #assembloids #braindisorders

In this week’s @nature.com, we publish a group effort to outline a framework for studies with neural #organoids, #assembloids and transplantation. More details below 1/n

Macrophages protect against sensory axon loss in peripheral neuropathy - Nature A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.

Macrophages protect against sensory axon loss in peripheral neuropathy @Nature
www.nature.com/articles/s41...

In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:

www.biorxiv.org/content/10.1...

Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.

@uclqsion.bsky.social #aging

An in vitro model for studying crosstalk between muscle cells and neurons Muscle contraction and exercise are critical for peripheral nerve growth and innervation. Studying this interplay is challenging given the difficulty of decoupling mechanical from biochemical stimulat...

So exciting to see our newest paper on muscle-nerve crosstalk featured in this @cellpress.bsky.social Device perspective - thanks to Claudia Loebel and team for highlighting our work! 💪🏽

www.cell.com/device/abstr...

Great group, I would love to be added!

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...

👏 to Tetsuo Hasegawa & others of Clatworthy lab
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...

Great collection! I would like to join as well! 😊