L.-C. Campeau

😬

General synthesis of 2,1-benzisoxazoles (anthranils) from nitroarenes and benzylic C–H acids in aprotic media promoted by combination of strong bases and silylating agents - Molecular Diversity Carbanions of phenylacetonitriles, benzyl sulfones, and dialkyl benzylphosphonates add nitroarenes at the ortho-position to the nitro group to form $$\sigma ^\mathrm{H}$$ σ H -adducts that, upon treat...

Safety/Toxicity alert! In this synthesis cyanide is formed and the procedure uses acidic workup. Hydrogen cyanide will be formed! There is no warning. @springernature.com link.springer.com/article/10.1... #ChemSky @drlcsquare.bsky.social @bagphos.bsky.social

me paying $30 in gas to buy imported things that have been hit with tariffs bc joe rogan is learning about politics at age 58

Honorary member perhaps.

Another paper from our collaboration with Rob Britton’s lab! We’ve been focusing on novel methods to make nucleoside analogues for over 7 years now. This week we published our 2nd Science paper in the area. Congrats to the team! #MerckChemistry

www.science.org/doi/10.1126/...

Will be moving to a locale with fairly limited lab-based process chemistry positions available come July. as such I'm becoming more invested in searching for fully remote #chemjobs - preferably in the process chemistry ouvre, at this point open to others as well. Advice or help greatly appreciated

They have self checkout now… so it would be my fault.

Having to show the Costco guy your receipt when you are just standing there holding your 4.99$ chicken will never make sense to me.

mRNA cancer vaccine shows protection at 5-year follow-up, Moderna and Merck say The vaccines are tailor-made to target each patient's unique cancer.

Some fantastic news!
arstechnica.com/health/2026/...

This, right here 🎯💯. I’ve been trying to communicate this to people, as a native 🇨🇦, for a year now. Again, the fact that this wasn’t immediately seen as a presidency-ending, beyond-the-pale thing for all 535 Congresspeople, the media, & the public is deeply ugly & shameful for us as a country.

That Venn diagram has to be tiny!

Bruh!

Perfect pairing for the Apple crisp!

Early Xmas surprise for the kids last night. Really great show! They even had butter beer. #CursedChildNYC

Mmmmmm…

Check out the pre-print below to learn more!

chemrxiv.org/engage/chemr...

The improvements in sustainability metrics are quite astonishing with PMIs 1 to 2 orders magnitude better than conventional solid-phase peptide synthesis (SPPS) methods. The bonus is that all of it can be run in conventional small molecule manufacturing equipment unlike most SPPS approaches.

This week I'm excited to share the latest of these innovations, the liquid-phase peptide synthesis (LPPS) via N to C chain growth of peptide fragments using unprotected free amino acids. This new platform enables the synthesis of fragments and further coupling of these to make linear peptides.

The field of peptide therapeutics is exploding with many new approvals in the last decade. However, the manufacturing of peptide therapeutics is lagging behind. We have been investing in novel approaches to manufacture peptides since 2016.

FDA says it may relax warning label rule for dietary supplements Supplements aren’t reviewed for safety and effectiveness, but disclaimers about health benefits are required on products.

“because dietary supplements aren’t reviewed before they’re sold, the products can contain different amounts of ingredients than what’s listed on the label — or ingredients not listed at all.”

And now they want to relax warning labels for dietary supplements
www.nbcnews.com/health/healt...

Wait, you’re a St Viateur guy?

Then a quick sear of the outside.

145 F, 2.5-3h

You can make this gravy ahead of time and freeze until Thanksgiving.

Fun fact, the 2019 NOS speaker lounge was moved to the field house to accommodate @drlcsquare.bsky.social’s giant gummy bear

For this who want the secret, it’s turkey wings!!!

Paired great with this Joy Fantastic Pinot from sta. Rita Hills.

Happy 🦃 day! Spent most time on the gravy. Sous-vide turkey breast FTW! #ChemistsWhoCook

An anion-binding approach to enantioselective photoredox catalysis Photoredox catalysis has emerged as a transformative strategy in synthetic chemistry, enabling a wide variety of valuable chemical reactions through generation of highly reactive radical ion intermedi...

In @science.org this week, Petra Vojáčková and Eric Jacobsen report that thiourea-based anion binders can render photoredox catalysis enantioselective by pairing with cation radical intermediates

chemsky 🧪

www.science.org/doi/10.1126/...