PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized non-ribosomal proteins https://www.biorxiv.org/content/10.64898/2025.12.17.694911v1

Small alligator rescued in Boston after slithering into the city's heart on social media The small alligator, spotted along the Charles River in Boston multiple times this week, has been rescued and delivered to safety, wildlife officials in Massachusetts said Thursday.

The small alligator, spotted along the Charles River in Boston multiple times this week, has been rescued and delivered to safety, wildlife officials in Massachusetts said Thursday.

MillionFull enables massive, full-length enzyme sequence-fitness data collection at low cost for machine learning-guided enzyme engineering https://www.biorxiv.org/content/10.1101/2025.10.24.684421v1

Animals at zoos across the United States got into the Halloween spirit this month. 🎃

Video via Oregon Zoo via Storyful and AP, Point Defiance Zoo & Aquarium via Storyful and the John Ball Zoo via AP

Microbial stem cells support productivity in dedicated factory cells in an asymmetrically dividing E. coli system https://www.biorxiv.org/content/10.1101/2025.10.01.679865v1

Inside a Plant Engineering Lab Challenges and opportunities in plant (genetic) engineering with Vivian Zhong and Alexander Borowsky from the Brophy Lab

Latest BIOPUNK interview by the amazing Sophia Sanchez is focused on plant engineering! @vivzhong.bsky.social and @atborowsky.bsky.social discuss their goals and motivations 🪴 💕 . www.biopunk.life/p/full-video...

Check out Sophia's whole series at biopunk.life

🚨I have a fully funded 4-year #PhD opportunity in my lab on 'Tuneable multi-input genetic logic circuits for designer probiotics'.🦠 We'll be throwing all the tech we have at this one to make reliable engineering of diverse microbes a reality. Applicants must be UK national...

This image is figure 1 showing sterol nutrition of a honeybee colony.

The introduction of a genetically modified yeast strain into honeybee diets could help sustain brood production during periods of pollen scarcity, according to a study published in Nature. go.nature.com/3UKdAtc 🧪

Active learning-guided optimization of cell-free biosensors for lead testing in drinking water https://www.biorxiv.org/content/10.1101/2025.08.20.671382v1

groovDB in 2026: A community-editable database of small molecule biosensors https://www.biorxiv.org/content/10.1101/2025.08.18.670880v1

Plasmid prevalence is independent of antibiotic resistance in environmental Enterobacteriaceae The rapid rise of antibiotic-resistant pathogens poses a critical threat to the treatment of infectious diseases. While the spread of antibiotic resistance genes (ARGs) via plasmid conjugation has bee...

If you ever find yourself needing evidence for ‘Plasmids are just as common in microbes without resistance genes,’ we’ve got you covered! Check our new paper, out today:

www.microbiologyresearch.org/content/jour...

At 48 years old, Jen Pawol became the first female umpire in Major League Baseball history on Saturday when she made her regular-season debut working the bases at the Miami Marlins and Atlanta Braves games.

An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functions. We describe an orthogonal DNA replication system in ...

An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli | Science https://www.science.org/doi/full/10.1126/science.adp9583?af=R

This is figure 1, which shows the identification of RUMTOR_00181 and RORDEPs.

Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents, according to a paper in Nature Microbiology. go.nature.com/3IUZ2o0 🧪

Jennifer Doudna is named 2026 Priestley Medalist The award recognizes the biochemist for discoveries on ribozyme function and CRISPR gene editing, and international science leadership

@acs.org is recognizing Jennifer A. Doudna with the Priestley Medal for her discoveries on ribozyme function, the Dicer RNase enzyme, double-stranded RNA processing, and CRISPR gene editing, along with her impactful international science leadership. cen.acs.org/people/award... #chemsky 🧪

This is figure 1, which shows the front flipper of Temnodontosaurus trigonodon with soft tissues.

Ichthyosaurs — marine reptiles from the Mesozoic era that resembled dolphins — may have had specialized fins that allowed them to sneak up on prey by reducing ambient noise, according to a paper in Nature. go.nature.com/4lWrV1d #Paleosky 🧪

Comparing LigandMPNN and Directed Evolution for Altering the Effector-Binding Site in the RamR Transcription Factor https://www.biorxiv.org/content/10.1101/2025.07.10.663684v1

Have you tried @ansabio.bsky.social?

bsky.app/profile/ansa...

ansabio.com/products/50kb/

This is figure 2 showing how SNAP-tag engineering is aiming for faster and brighter fluorescence labeling

SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in Nature Chemical Biology presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/46fMIZd 🧪

This is figure 1, which shows aniline synthesis from carboxylic acids in vitro and in vivo.

Escherichia coli bacteria (E. coli) can convert a molecule derived from a waste plastic bottle into paracetamol, a pain medication also known as acetaminophen, according to a paper in Nature Chemistry. go.nature.com/44cvLw1 #chemsky 🧪

Good luck in your next adventure, buddy. It was a blast working with you.

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

Today in Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III & deBz-deoxy-Taxol #SingleCell #secmet 🧬🧪🌾

Recombinases your thing? In the latest from my lab, Veronica Greco shows how @nanopore sequencing + automated liquid handling provides the perfect platform for characterising these systems at scale! Awesome collaboration with @jennbrophy.bsky.social @sarah-guiziou.bsky.social doi.org/10.1101/2025...

Coral meditation in the Coral Morphologic lab #coralmorphologic #miami

Five Plays The Highlights Industry Will Just Ignore The best NSAs of the past month or so

Pretty pictures & no paywall for this one
pebblehunting.substack.com/p/five-plays...

RootPath is a new DNA synthesis company and they're planning to give away 3 million bp of free gene synthesis to the best ideas as part of a launch promo competition. Free stuff! Tell your friends.

Modular Engineering of Thermo-Responsive Allosteric Proteins https://www.biorxiv.org/content/10.1101/2025.05.02.651844v1

Escherichia coli with a 57-codon genetic code https://www.biorxiv.org/content/10.1101/2025.05.02.651837v1

What Are You Willing To Bring To The Game To Help Your Team Win? A loophole for fans; a baffling progression for Aaron Judge.

They're doing their part. Are you?
pebblehunting.substack.com/p/what-are-y...

Accelerated evolution of whole gene clusters by an engineered lytic phage system in E. coli https://www.biorxiv.org/content/10.1101/2025.04.21.649713v1