Charles Mullighan

MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia NUP98 fusion oncoproteins (FOs) are a hallmark of childhood acute myeloid leukemia (AML) and drive leukemogenesis through liquid-liquid phase separation-mediated nuclear condensate formation. However,...

Our preprint led by Nicole Michmerhuizen and Emily Heikamp showing the key role and targetability of the MOZ/MORF history acetyltransferases in high-risk NUP98-rearranged acute myeloid leukemia.

www.biorxiv.org/content/10.1...

Ilaria Iacobucci presenting work from the lab showing the key role of heme metabolism in erythroleukemia #ASH2024

#ASH2024

Genomic profiling of circulating tumor DNA for childhood cancers - Leukemia Leukemia - Genomic profiling of circulating tumor DNA for childhood cancers

Glad to share the work of the fantastic Cancer Biomarkers Laboratory of St Jude showing the power and utility of cell free genomic analysis to detect diverse genomic variants in leukemia and many solid tumors. Exciting potential for mutation-specific monitoring. www.nature.com/articles/s41...