Marie Binvignat

Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis Objective Pain is the hallmark symptom of osteoarthritis (OA), and its biologic drivers remain poorly understood. Although the role of innate immunity in OA has been extensively studied, the involve...

So happy to share my PhD work on Treg dysfunction in osteoarthritis

Kudos to my PhD supervisors !
@enkrnita.bsky.social
@jeremiesellam.bsky.social

acrjournals.onlinelibrary.wiley.com/doi/full/10....

@sorbonne-universite.fr
@ap-hp.bsky.social
@larhumato.bsky.social

Interpretable inflammation landscape of circulating immune cells - Nature Medicine Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.
https://www.nature.com/articles/s41591-025-04126-3

Thrilled to share our new paper comparing different LLMs to extract TNFi reasons and treatment trajectories from UCSF de-identified EHR data with @bmeow19.bsky.social, A. Garcia-Agundez and @jyazdanymd.bsky.social published in JAMIA open.

academic.oup.com/jamiaopen/ar...

@ucsf-bchsi.bsky.social

This is figure 2, which shows AlphaProof’s learning and adaptation processes.

A paper in Nature describes an AI system that can prove complex mathematical theories. The system, Google DeepMind’s AlphaProof, has achieved a silver medal-worthy performance at the 2024 International Mathematics Olympiad. go.nature.com/4qUObvN 🧪

The T cells in these patients showed increased metabolic activity. Elevated levels of inflammatory molecules (IL-6, IL-12, and type I interferon) may be driving the aggressive T cell behavior. #ACR25

Remembering Atul Butte This Medical News article is in remembrance of Atul Butte, MD, PhD, a pioneer in using data science to improve health.

Atul Butte, MD, PhD, helped define the field of translational bioinformatics and inspired countless colleagues and trainees.

He will be remembered for his brilliant mind, infectious optimism, generous mentorship.

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

Fresh from the oven 🧨💥

We show that CD4 T cells, especially Tregs, control host-microbiota symbiosis and intestinal barrier integrity to prevent inflammaging, tissue senescence and aging-related multimorbidity

🔥 👵🏻

www.science.org/doi/10.1126/...

T-cell receptor repertoire and HLA in osteoarthritis: A systematic literature review The aim of this systematic literature review was to provide a comprehensive overview of T-Cell Receptor (TCR) mediated immunity research in osteoarthritis (OA).

Congrats to @mariamarcosalvador.bsky.social on her first publication, just out in @oacjournal.bsky.social !

A systematic literature review on TCR and HLA in osteoarthritis:
🔗 www.oarsijournal.com/article/S106...

@enkrnita.bsky.social @jeremiesellam.bsky.social @sorbonne-universite.fr

UCSF Bioinformatics Pioneer Atul Butte Dies at 55 Atul Butte, who championed the use of big data in science and health care and inspired a generation of trainees at UC San Francisco and beyond to pursue the fields he pioneered — translational and cli...

The UCSF community mourns the passing of Atul Butte, MD, PhD, a bold thinker, inspiring mentor and founding director of the Bakar Computational Health Sciences Institute.

tiny.ucsf.edu/tGz3QY

Immune-cell profiling to guide stratification and treatment of patients with rheumatic diseases - Nature Reviews Rheumatology In this Review article, the potential of cytometry- and single-cell RNA sequencing-based immune profiling for aiding the diagnosis and personalized treatment of rheumatic diseases is discussed.

Review @natrevrheum.nature.com @deepakarao.bsky.social
Immune-cell profiling to guide stratification and treatment of patients with rheumatic diseases
www.nature.com/articles/s41...

Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3 Acute Foxp3 protein depletion selectively affects Treg cells responding to type 1 inflammation.

Recently in #Science #Immunology: Van der Veeken & al @ IMP @viennabiocenter.bsky.social generated 🐁 w auxin-inducible degradable #Foxp3! Tissue #Tregs minimally unaffected @ homeostasis but highly dependent on continuous Foxp3 activity in models of #autoimmunity, #viral #infection, & #cancer !

🚨 NEW 🚨

🤩 This month's Editors Choice (Clinical) is about intestinal health and hand #osteoarthritis

Read more from @mbinvignat.bsky.social @jeremiesellam.bsky.social - www.oarsijournal.com/article/S106...

Molecular endotypes and theratypes in osteoarthritis: transforming a concept into reality with deep learning and multiomics Osteoarthritis (OA) is now understood as a heterogeneous disease in many respects, including its clinical presentation, underlying pathophysiological mechanisms, and response to treatments. Distinct p...

Check out our new editorial on molecular endotypes and theratypes in osteoarthritis with @jeremiesellam.bsky.social, just out in Annals of the Rheumatic Diseases

ard.eular.org/article/S000...

@crsa-paris.bsky.social @sorbonne-universite.fr

UCSF Scientist Receives High Honor for Exceptional Career Researcher and campus leader Atul Butte, MD, PhD, has been recognized for his outstanding career in the computational and health sciences with induction into the American Academy of Arts and Sciences,...

We’re proud to celebrate @atulbutte.bsky.social on his election to the American Academy of Arts and Sciences, one of the nation’s oldest honor societies. A leader in biomedical data science, his work is reshaping how we diagnose and treat disease. tiny.ucsf.edu/CUz7gN

Serum intestinal permeability biomarkers are associated with erosive hand osteoarthritis and radiographic severity: results from the DIGICOD cohort To investigate the association between intestinal permeability alteration and erosive hand osteoarthritis (EHOA).

Happy to share our new article on Intestinal Permeability serum biomarkers in Erosive hand OA with @jeremiesellam.bsky.social @larhumato.bsky.social @enkrnita.bsky.social and team

Read the paper here: www.oarsijournal.com/article/S106...

@crsa-paris.bsky.social @oacjournal.bsky.social