Read our @natgenet.nature.com News&Views on the impressive work by @muzumdarlab.bsky.social and @sstevenwang.bsky.social.
How does the 3D genome guide Kras-driven cancers evolution?
Find out with single-cell genome-wide chromatin tracing!
📖https://rdcu.be/eShAY
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
5/2025 Issue ➡️ www.embopress.org/toc/17444292...
tissue-specific huntingtin interactomes, gene product diversity evolution
Cover: mammalian promoters characterised by low RNA pol II occupancy and high turnover @kasitc.bsky.social @molinalab.bsky.social @arnaudkr.bsky.social
Don't forget to checkout our annex pre-print bit.ly/3EkRqJh for a sense on our new 💻 tool FootprintCharter, for the unsupervised footprint quantification from single molecule data. Available on Bioconductor at bit.ly/3XLe8RC.
And a shoutout to my UNBELIEVABLE co-first @valentinabaderna.bsky.social and co-authors @kasitc.bsky.social @lauramoniotperron.bsky.social Rozemarijn Kleinendorst...time to ring the bell 🔔🔔🔔🔔🔔
Having a stressful day? Lay back, crack a beer open and read about how chromatin accessibility responds to perturbations of TF binding at the single molecule level bit.ly/3XQMFxN. I'm incredibly thankful to my PhD mentors @arnaudkr.bsky.social and Judith Zaugg for these super productive years!!
Wooa finally out!! Congratulation mate 👏👏👏
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...
