Emerald Perlas 🇵🇭🇺🇸🇮🇹

Spatial transcriptomics maps host–gut microbiome biogeography at high resolution
rdcu.be/e7LqK

High-sensitivity in situ detection of Sox21 reveals transcript asymmetry from the zygote stage The first lineage decision in mammalian development segregates embryonic and extra-embryonic fates, yet the timing of this specification remains under…

High-sensitivity in situ detection of Sox21 reveals transcript asymmetry from the zygote stage
www.sciencedirect.com/science/arti...

An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis
rdcu.be/e6qmL

An image-based transcriptomics atlas reveals the regional and microbiota-dependent molecular, cellular, and spatial structure of the murine gut The gut is composed of a remarkable diversity of cells that, through diverse small-molecule receptors, sense a complex mix of diet-, self-, and microbial-derived molecules. Xu et al. leverage image-ba...

Spatial atlas of murine gut

Image-based transcriptomics inform cell-type expression & spatial organization of receptors sensing diet-, self- & microbial-derived molecules in murine gut. Work uncovers microbiota-dependent modulation of gut structure
www.cell.com/cell-host-mi...

Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells Proper differentiation of gonadal somatic cells is crucial for sex determination and the production of sex hormones and gametes, and reconstituting this process in culture would both deepen our unders...

Reconstitution of sex determination and the testicular niche using mouse pluripotent stem cells | Science www.science.org/doi/10.1126/...

In case you missed it: our review titled "Spatial structure: shaping the ecology and evolution of microbial communities" is out! 🚨

Let me hit you with some highlights on why spatial structure matters. (and why you should care!)

Sharing is appreciated 🙏 🧵👇

doi.org/10.1093/fems...

Identification of endometrial CD169+ macrophages essential for Treg cell accumulation and implantation @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Scalable spatial transcriptomics through computational array reconstruction - Nature Biotechnology An imaging-free spatial transcriptomics method facilitates high-throughput barcode array generation up to centimeter scale.

An imaging-free spatial transcriptomics method facilitates high-throughput barcode array generation up to centimeter scale go.nature.com/3QYfSDd
rdcu.be/e4Db0

A whole-brain single-cell atlas of circadian neural activity in mice The mammalian brain comprises numerous anatomical regions with distinct functions despite their extensive connectivity. How spontaneous neural activity is coordinated across regions over the circadian...

A whole-brain single-cell atlas of circadian neural activity in mice | Science www.science.org/doi/10.1126/...

Loke CTR Annual Meeting 2026 - Epigenetics of embryogenesis and placentation | Loke Centre for Trophoblast Research Register for in-person Register for online The 2026 Loke CTR annual meeting theme, “Epigenetics of embryogenesis and placentation” brings together leading clinical and basic scientists to explore…

This July join us in Cambridge (or online) for our Annual Meeting 'Epigenetics of embryogenesis and placentation'

📅 16-17 July 2026
📍 St John’s College, Cambridge, UK (in-person or full programme available online)

👉 Learn more and register here: www.trophoblast.cam.ac.uk/ctrconferences

Pregnancy-associated shifts in maternal microbiota across multiple body sites can signal to the placenta, influencing its function and fetal development.

Maternal microbial ecosystems are key in shaping reproductive physiology and pregnancy outcomes. While the gut microbiota has been extensively studied, the roles of microbes in other body regions are less clear. This #IAIJournal review provides insights: asm.social/2OQ

Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging - The EMBO Journal Sperm aging impacts male fertility and offspring health, highlighting the need for reliable aging biomarkers to guide reproductive decisions. However, the molecular determinants of sperm fitness durin...

link.springer.com/article/10.1...

Pregnancy is a miraculously odd state of existence defined by a slew of changes, including to the immune system. These shifts are linked to everything from food aversions to infections, with important implications for pregnancy outcomes. Read the article: asm.org/articles/202...

ICYMI

Single-cell and spatial transcriptomics unveils key regulators governing cell differentiation for Schistosoma sexual development
www.biorxiv.org/content/10.6...

Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency Currently, no effective treatment exists for infertility associated with premature ovarian insufficiency (POI) because affected patients lack hormone-responsive antral follicles. By screening a Food a...

Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency | Science www.science.org/doi/10.1126/...

Happy to announce that our review article on vesicle-coupled mRNA trafficking is now availalbe

@mibinet.bsky.social

#EMBOrnaLocalization

link.springer.com/article/10.1...

Integrins mediate symbiont-specific uptake in cnidarian larvae - EMBO Reports Endosymbiosis between dinoflagellate algae and cnidaria is fundamental for coral reef health. Appropriate symbiont selection is required for sufficient host nutrient acquisition and could be tailored ...

link.springer.com/article/10.1...

Decoding the heterogeneity of human undifferentiated spermatogonia reveals RAS-dependent regulation of stem cell fate Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and hold therapeutic potential for treating male infertility. While roden…

www.sciencedirect.com/science/arti...

The topographical distribution of spermatogonial subpopulations during the cycle of seminiferous epithelium in Macaca Fascicularis† Summary sentence We reveal stage-dependent spatial patterns of spermatogonial subpopulations in Macaca fascicularis, uncovering dynamic niche interactions

topographical distribution of spermatogonial subpopulations during the cycle of seminiferous epithelium in Macaca Fascicularis† url: academic.oup.com/biolreprod/a...

Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis Author summary Mitochondria are energy generators inside our cells, and they carry their own DNA (mtDNA). Due to inadequate DNA repair mechanisms in the mitochondria, mitochondrial genome contains mor...

Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis | PLOS Genetics share.google/WTSK6Pgocmn6...

Figure 3: CCNA2 protein expression is downregulated during the transition from mitosis to meiosis by MEIOC and STRA8. (C) Labeling of CCNA2 in DDX4-positive oogenic cells from wild-type, Stra8 knockout, Meioc knockout and Meioc Stra8 double knockout (dKO) ovaries at E16.5. Arrows and arrowheads mark EdU-positive and -negative oogenic cells, respectively. Meioc Stra8 double knockout panel also appears in Fig. 1B. Scale bar: 20 µm. (D) Quantification of CCNA2 intensity in EdU-positive and -negative oogenic cells. Data for EdU-positive cells represents 190 cells from five wild-type embryos, 35 cells from five Stra8 knockout embryos, 144 cells from three Meioc knockout embryos and 124 cells from three Meioc Stra8 double knockout embryos. Data for EdU-negative cells represents 2492 cells from five wild-type embryos, 579 cells from five Stra8 knockout embryos, 909 cells from three Meioc knockout embryos and 296 cells from three Meioc Stra8 double knockout embryos. Dot represents the median; whiskers represent the interquartile range. *adj. P<0.05; **adj. P<0.01; ****adj. P<0.0001. See Table S4 for statistical details.

MEIOC facilitates meiotic entry in the mammalian female germ line

This Research Highlight showcases work by Esther G. Ushuhuda, Maria M. Mikedis (@mariamikedis.bsky.social) and colleagues:

journals.biologists.com/dev/article/...

The authors did such a great job making this spatial transcriptomics data of ovulating mouse ovaries available: www.pnas.org/doi/10.1073/...

So I vibe coded a web browser app to interactively explore its spatiotemporal gene expression trends: jef.works/CellCarto-Ov...

Hope it's useful!

David Byrne: Tiny Desk Concert In matching, brilliant blue suits, David Byrne and his band squeeze behind the Desk to perform four songs, including Talking Heads' "Life During Wartime."

In matching, brilliant blue suits, David Byrne and his band squeeze behind the Desk to perform four songs, including Talking Heads' "Life During Wartime." n.pr/4pFYoun

5th International Antibody Validation Meeting - YouTube Listen to talks from the speakers at the 5th AbVal meeting, held in Bath on the 9-11th September 2025.

Bad antibodies are a major roadblock in biomedical research, harming reproducibility and wasting resources.

The International Antibody Validation Meeting was created to fix it.

Watch the talks from the 5th Antibody Validation Meeting (2025)
tinyurl.com/AntibodyVali...
#Integrity #reproducibility

Vitamin C conveys geroprotection on primate ovaries Jing et al. demonstrate that oral vitamin C supplementation delays ovarian aging in non-human primates, attenuating key aging hallmarks and rejuvenating the ovarian cellular and molecular profiles. Th...

Vitamin C conveys geroprotection on primate ovaries: Cell Stem Cell www.cell.com/cell-stem-ce...

ICYMI

A spatiotemporal molecular atlas of the ovulating mouse ovary | PNAS www.pnas.org/doi/10.1073/...

Generation of germinal-vesicle oocytes from mouse embryonic stem cells under an ovarian soma-free condition Using mouse pluripotent stem cells, Nosaka et al. created an ovarian somatic cell (OSC)-free system to induce an abundant number of oocyte-like cells at diplotene arrest, followed by their growth into...

Generation of germinal-vesicle oocytes from mouse embryonic stem cells under an ovarian soma-free condition: Developmental Cell www.cell.com/developmenta...

Don't miss the chance to join us in Heidelberg for the EMBL Course #EMBLSpatialOmics! Apply by 24 Nov: https://s.embl.org/spa26-01-bl

🧬🔬🧪 Our trainers and speakers will introduce participants to a new generation of spatially resolved transcriptomics assays from 10x Genomics.

🗓️ 2 – 6 Mar 2026

Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway - Nature Neuroscience Buron et al. show that oxytocin enhances heart rate variability linked to breathing during recovery from stress. This calming and cardio-protective effect is produced through a hypothalamus–brainstem ...

Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway

@julie.buron.bsky.social @inmed.bsky.social @insermpacacorse.bsky.social D54@incia-neurocampus.bsky.social

www.nature.com/articles/s41...

Enhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules - Nature Communications Systematic discovery of proteins interacting with low-abundance RNAs is challenging. Here, the authors develop an enhanced HyPro technology to identify proteins associated with compact RNA compartment...

www.nature.com/articles/s41...