Michele Acconcia's Avatar

Michele Acconcia

@mich-acconcia

PhD student in the @gozziale.bsky.social Functional Neuroimaging Lab

120
Followers
138
Following
7
Posts
23.09.2023
Joined
Posts Following

Latest posts by Michele Acconcia @mich-acconcia

I'm SO tired of people looking for "the neuroscience of X" (meaning uninformative neuroimaging pictures) when *the psychology of X* is right there, doing a perfectly good job...

21.02.2026 11:52 πŸ‘ 152 πŸ” 28 πŸ’¬ 6 πŸ“Œ 0
Post image

🐭🧠 Can fUSI truly map canonical mouse resting-state networks β€” and how does it compare to fMRI?

I’m excited to share the work of my PhD in our new preprint!πŸ‘‰ doi.org/10.64898/202...

Go check it out β€” it’s time to expand your neuroimaging toolkit πŸ§ πŸš€

11.02.2026 18:09 πŸ‘ 17 πŸ” 11 πŸ’¬ 1 πŸ“Œ 0
Preview
Prefrontal neural geometry of learned cues guides motivated behaviours - Nature The dorsomedial prefrontal cortex encodes the value, salience and valence of learned stimuli along distinct neural dimensions, and the geometry of these representations shapes motivated behaviours in ...

Can you easily distinguish between value, valence, and salience?

Probably not, but the prefrontal cortex of mice seems to achieve this by creating a sort of multidimensional orthogonal neural space, where each dimension corresponds to one of these subjective elements

www.nature.com/articles/s41...

09.02.2026 13:31 πŸ‘ 46 πŸ” 20 πŸ’¬ 1 πŸ“Œ 0
Preview
Rethinking the centrality of brain areas in understanding functional organization Nature Neuroscience - Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas...

New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . β€œRethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧡

rdcu.be/eVZ1A

23.12.2025 13:02 πŸ‘ 253 πŸ” 99 πŸ’¬ 9 πŸ“Œ 10
Post image

Wrapping up 2025 with the lab.

Proud moments (including some I once thought impossible) and so many failures, living side by side, as science does. We stuck with it together. Grateful for the shared effort, trust, and fun that shaped this year.

Wishing everyone a peaceful holiday break!

19.12.2025 14:48 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Preview
How distributed is the brain-wide network that is recruited for cognition? - Nature Reviews Neuroscience Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...

How distributed is the brain-wide network that is recruited for cognition? A Perspective by Matthew C. Rosen & David J. Freedman

#neuroscience #neuroskyence

www.nature.com/articles/s41...

04.12.2025 09:30 πŸ‘ 19 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0

I wrote a book: "The brain, in theory".
First chapter and TOC:

romainbrette.fr/WordPress3/w...

18.12.2024 06:50 πŸ‘ 40 πŸ” 7 πŸ’¬ 2 πŸ“Œ 2
Lunchtime Talk - Joe McCaffrey 11/7/25
Lunchtime Talk - Joe McCaffrey 11/7/25 YouTube video by Center for Philosophy of Science

very nice talk by Joe McCaffrey on functional localizationβ€” it’s an easy listen with tons of great information about the debate.

m.youtube.com/watch?v=eRmD...

09.11.2025 21:54 πŸ‘ 11 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0
Preview
An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening The locus coeruleus has a specialized pathway to the brainstem that controls sound-evoked awakening from sleep.

🚨 New paper alert! 🚨(1/6)

Excited to share our work, out now in Science Advances

We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...

10.09.2025 18:30 πŸ‘ 27 πŸ” 10 πŸ’¬ 1 πŸ“Œ 4

Working link to the preprint πŸ‘‡
www.biorxiv.org/content/10.1...
See thread below for a looong explainer

10.09.2025 17:48 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

#NeuroJobs

10.09.2025 10:16 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

But couldn’t the opposite be true as well? To say that a cell has a very specific tuning to a category shouldn’t it probed with a really large sample of concepts? After all the ~100 of the paper represents a fairly limited sample space

05.09.2025 14:15 πŸ‘ 3 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0

Too often, I see people talk about a replication as if the first study has established something, and the replication study is a double-check. What people often fail to understand is that we do not do replication studies to *check* a finding, but to *establish* a finding. 1/x

17.08.2025 06:36 πŸ‘ 152 πŸ” 40 πŸ’¬ 1 πŸ“Œ 1
Preview
Supergroup (music) - Wikipedia

A superlab paper?

en.m.wikipedia.org/wiki/Supergr...

05.08.2025 07:00 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Preview
Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds Ultra-slow, ∼0.1-Hz variations in the oxygenation level of brain blood are widely used as an fMRI-based surrogate of β€œresting-state” neuronal activity…

This review may be relevant. They argue that BOLD results mainly from the entrainment of blood vessels on the (low-frequency) envelope of gamma neural oscillations

www.sciencedirect.com/science/arti...

21.07.2025 13:53 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thinking about writing a pop science book about the brain (β€œYour Brain on Everything”) where the big reveal is that all the brain names were randomized and I was actually talking about psychology the whole time.

13.07.2025 20:21 πŸ‘ 42 πŸ” 7 πŸ’¬ 2 πŸ“Œ 0
Preview
Cholinergic feedback for modality- and context-specific modulation of sensory representations The brain’s ability to prioritize sensory information is crucial for adaptive behavior, yet its mechanisms remain unclear. We investigated basal forebrain cholinergic neurons modulating olfactory bulb...

Our new paper is out in Science.

We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change.

Congrats to Bin for the great thesis, and the team!

www.science.org/doi/10.1126/...

20.06.2025 15:32 πŸ‘ 126 πŸ” 34 πŸ’¬ 0 πŸ“Œ 3

Is the "homunculus" that supposedly monitors the activity of the mid-level visual cortex real or imaginary?

11.06.2025 13:53 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

An important question than is: if this work was advertised as exploratory research, would it still be published in Science? (Of course, this is likely a problem that affects the publication process in general, rather than this paper specifically; we should probably work to change that)

03.06.2025 12:33 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

And probably we didn’t even moved on completely. I think it’s still considered true by the general public

25.05.2025 12:58 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
Integrating multimodal data to understand cortical circuit architecture and function - Nature Neuroscience This paper discusses how experimental and computational studies integrating multimodal data, such as RNA expression, connectivity and neural activity, are advancing our understanding of the architectu...

Advances in neuroscience have yielded massive, rich datasets from various analysis techniques and modalities. πŸ§ πŸ“ˆ

In a @natureneuro.bsky.social perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain.

25.03.2025 18:59 πŸ‘ 45 πŸ” 14 πŸ’¬ 5 πŸ“Œ 1
Preview
Beyond Mechanismβ€”Extending Our Concepts of Causation in Neuroscience The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c...

Beyond Mechanismβ€”Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/... - really pleased that this paper with Henry Potter is now published in the European Journal of Neuroscience 😊

14.03.2025 10:25 πŸ‘ 211 πŸ” 73 πŸ’¬ 15 πŸ“Œ 15