MargolisLab

Another promising finding for 5HT4R agonism! This study found that in participants with previous episodes of depression, 5-HT4R agonist, prucalopride, had pro-cognitive effects (learning, memory & attention).
@karapedsgastrodoc.bsky.social

doi.org/10.1016/j.ns...

Long-term risk of irritable bowel syndrome associated with adverse childhood and adulthood experiences: a large-scale prospective cohort study - Translational Psychiatry Translational Psychiatry - Long-term risk of irritable bowel syndrome associated with adverse childhood and adulthood experiences: a large-scale prospective cohort study

A large cohort study of 126,735 adults followed over 14.5 years show the high prevalence of IBS cases in instances of severe emotional and physical neglect, as well as abuse.
@karapedsgastrodoc.bsky.social

www.nature.com/articles/s41...

A gut-acting 5-HT4 drug, prucalopride, shows faster antidepressant/anxiolytic effects than fluoxetine in mice, with parallel shifts in the microbiome.
@karapedsgastrodoc.bsky.social

www.nature.com/articles/s41...

Ultraprocessed Food Consumption and Behavioral Outcomes in Canadian Children This cohort study examines the associations between intake of ultraprocessed foods at age 3 years and behavioral outcomes at age 5 years among children in Canada.

Food is more than fuel for growing bodies, it may shape developing minds. Higher ultraprocessed food intake in preschool years was associated with more behavioral and emotional symptoms in early childhood.
@karapedsgastrodoc.bsky.social

jamanetwork.com/journals/jam...

Neuro-epithelial circuits promote sensory convergence and intestinal immunity - Nature Specific pain-sensing nociceptors and chemosensory tuft cells form a circuit to promote type 2 immune responses in the intestine.

Amazing new study shows how pain-sensing nerves work together with tuft cells of the intestinal epithelium to protect the gut from infection.
@karapedsgastrodoc.bsky.social
www.nature.com/articles/s41...

The Safety of Pharmacotherapy for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis Understanding the safety of pharmacotherapy for irritable bowel syndrome (IBS) enables individuals to make informed treatment decisions. While many studies include the number needed to treat to highlight therapeutic benefits, adding the number ...

Balancing benefit and risk is key in IBS therapy. Quantifying the ‘number needed to harm’ helps clinicians better evaluate treatment safety.
@karapedsgastrodoc.bsky.social

pmc.ncbi.nlm.nih.gov/articles/PMC...

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health - Nature Reviews Gastroenterology & Hepatology This Consensus Statement provides a definition of the term ‘gut health’, as well as a discussion of the relevant domains that contribute to gut health and a framework for appropriate use of the term i...

Gut health finally has a scientific definition. ISAPP’s new consensus defines it as normal GI function without disease or symptoms that affect quality of life.
@karapedsgastrodoc.bsky.social
www.nature.com/articles/s41...

This cool new paper reports an important characterization of how enteroendocrine cells in the gut are positioned relative to sensory neurons. Not surprisingly, there are significant regional differences along the GI tract!
@karapedsgastrodoc.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...

Interesting preprint showing that the behavioral effects of lithium are mediated by the gut-brain axis!

www.biorxiv.org/content/10.6...
@karapedsgastrodoc.bsky.social

Properties and functions of transcriptionally distinct enteric neurons The influence of the nervous system on the intestine is carried out by a combination of enteric, sensory, and autonomic innervation. However, disambig…

This study maps distinct enteric neuron subtypes and shows how each shapes key intestinal functions, from fecal output to feeding.
A big step forward in understanding gut–brain neural circuits.
www.sciencedirect.com/science/arti...
@karapedsgastrodoc.bsky.social

An enteric-DRG pathway for interoception and visceral pain in mice Wang et al. reveal a neuroanatomical and functional crosstalk between cholinergic enteric neurons and sensory neurons of the dorsal root ganglia that mediates colonic interoception. While this…

Enteric Neurons Join the Dialogue on Pain!

A recent study reveals that cholinergic circuits within the colon communicate through dorsal root ganglion (DRG) pathways, particularly following inflammation.
👉 www.cell.com/neuron/fullt...

🚨The NYU Pain Research Center (PRC) and Department of Molecular Pathobiology at NYU Dentistry are seeking Assistant or Associate Professors in the fields of chronic pain mechanisms, pain therapeutics, and related disciplines.

More info and apply:
apply.interfolio.com/176454

Distinguishing the causative, correlative and bidirectional roles of the gut microbiota in mental health - Nature Mental Health This Review provides a critical assessment of current mechanistic and clinical evidence on the interaction between the gut microbiota and mental health to differentiate causative, correlative and bidi...

📢New paper in Nature Mental Health!
Dr. @karapedsgastrodoc.bsky.social is co-author on a review exploring how the gut microbiota shapes mental health through the gut–brain axis.🧠

🔗 doi.org/10.1038/s442...

Big congratulations to postdoc @sarahanajjar.bsky.social on receiving a NIH K01 award to study serotonergic mechanisms of pain! 🌟 A huge step toward independence and groundbreaking discoveries ahead! 👏
@karapedsgastrodoc.bsky.social

Cool new study showing a comprehensive map of neuroimmune interactions throughout the gut!
www.pnas.org/doi/full/10....

@karapedsgastrodoc.bsky.social

Stomach–brain coupling indexes a dimensional signature of mental health - Nature Mental Health Using a relatively large and diverse sample of mostly young adults, this study by Banellis, Rebollo and colleagues examines associations between regional stomach–brain coupling and mental health and i...

New research highlights a stomach–brain connection in mental health.
👉 Stronger frontoparietal coupling to gastric rhythms = a marker of poorer mental health (anxiety, depression, stress, well-being).
Visceral rhythms aren’t just gut feelings, they shape our emotions
www.nature.com/articles/s44...

Happy Birthday to the best mentor ever, Prof. Margolis! 🥳 Thank you for always guiding and supporting us, we’re so lucky to learn from you!
@karapedsgastrodoc.bsky.social

@karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @linyhung.bsky.social @chalysthalee.bsky.social

Amazing week at ANMS 2025! 🌟
Sarah, Chalystha, Lin and Kara gave fantastic talks with Chalystha winning the Frank Hamilton Travel Award and Sarah named a Young Investigator Forum Fellow. Kara’s plenary lecture was a highlight, along with meeting Nobel laureate David Julius.

A gut sense for a microbial pattern regulates feeding - Nature A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.

New research reveals that the gut can sense microbial flagellin via TLR5-expressing neuropod cells, triggering PYY release & reducing feeding through a gut–brain neural circuit—independent of microbiota or immune cues.
@karapedsgastrodoc.bsky.social

🔗 www.nature.com/articles/s41...

Just back from a great week in Vienna for #ISSR2025. I am grateful for the travel award and the opportunity to share my work. Big thanks to @karapedsgastrodoc.bsky.social and Mike Gershon for their steady support in the lab and my career. Loved connecting with 5-HT researchers from around the world!

@karapedsgastrodoc.bsky.social gave a fantastic talk on the lab's important work on SSRI use in the gastrointestinal tract
@margolislabnyu.bsky.social highlighting @linyhung.bsky.social and @sarahanajjar.bsky.social 's work!
@nyupainresearch.bsky.social

Our amazing mentor and team lead @karapedsgastrodoc.bsky.social is now officially Professor Margolis! 👏👩‍🏫
She’s the definition of supportive, visionary, and unstoppable! no one deserves it more!
Feeling so lucky to be part of her team 💜
#ProfessorKara #WomenInScience #ProudTeam 💫🌟

Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice - Nature A study presents a strategy based on human pluripotent stem cells for treating neurodegenerative disorders of the gastrointestinal tract.

The Fattahi Lab successfully transplanted hPSC‑derived nitrergic enteric neurons into NO‑neuron–deficient mice, restoring gut motility, and created scalable 2D/3D human ENS models to support drug discovery and cell‑therapy approaches for enteric neuropathies.

www.nature.com/articles/s41...

Upper-gastrointestinal tract metabolite profile regulates glycaemic and satiety responses to meals with contrasting structure: a pilot study - Nature Metabolism In this randomized crossover pilot study, the authors collected human gastrointestinal digesta using a unique intubation technique to compare how meals with contrasting cellular structures affect post...

A new study shows that food structure plays a key role in determining which gut hormones are released.
@karapedsgastrodoc.bsky.social

#GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege

📖 Nature Metabolism
www.nature.com/articles/s42...

Blood-based T Cell Diagnosis of Celiac Disease Current diagnosis of celiac disease (CeD) is inaccurate in patients following a gluten-free diet (GFD). Blood-based diagnostics targeting gluten-speci…

🩸 A new blood test (WBAIL-2) detects gluten-triggered IL-2 release, offering a non-invasive, accurate way to diagnose celiac disease, even in patients on a gluten-free diet! 🌾❌
Game-changer for gut health.
sciencedirect.com/science/arti...

#guthealthmatters #WBAIL2
@karapedsgastrodoc.bsky.social

Big congrats to @linyhung.bsky.social on her Nature Reviews Journal Club piece spotlighting gut serotonin as a target for mood disorder treatment!
@karapedsgastrodoc.bsky.social

file:///C:/Users/Eb4415/Downloads/Hung-2025-Nature_Reviews_Gastroenterology_&_Hepatology.pdf

@chalysthalee.bsky.social @taeseonwoo.bsky.social @sarahanajjar.bsky.social @linyhung.bsky.social @danielxjuarez.bsky.social

🎉 Big wins for the Margolis Lab at AMPIRS 2025!

👏 Chalystha and Lin rocked their talks, Taeseon and Daniel nailed their posters, and Sarah delivered an epic flash talk!

🏆 Huge congrats to Lin and Sarah for taking 1st place! So proud of this amazing team! 💜🧠
@karapedsgastrodoc.bsky.social