Restaurants, billboards, commercials… what brain circuits link context to appetite? 🧠🌎🍽️
Very happy to finally share a major update in our work exploring the hippocampus and lateral septum in calibrating food consumption! 🍩
Major thanks to our lab and collaborators! ⭐️⭐️
www.cell.com/neuron/fullt...
FIRST post here on Bluesky - we’re excited to share that our large spatial transcriptomics study of the human dlPFC in schizophrenia is now available on bioRxiv📄: www.biorxiv.org/content/10.6... (1/9)
Excited to share our study in Neuron led by
@travisgoode.bsky.social, a K99 PDF (interviewing for Faculty) and Sahay lab team with collaborators at BROAD, Hopkins, and UW Seattle, defining a neural circuit that links prior experience with feeding behavior. Open Access: sahaylab.com/publications
🐐
Great feeling for a friday. First cell from the new rig. Still a lot of work to do on the rig, but we are patching. Feels like going back to your first love ❤️ 😍
New paper out on cortistatin neurons and their role in regulating fear and cortical hyperexcitability in the prelimbic cortex! This one has been a fun ride 🧵 www.biorxiv.org/content/10.6...
Now online! @lieberinstitute.bsky.social & @jhubiostat.bsky.social collaboration generating important resource (Visium & Xenium) on molecular organization of human hypothalamus w/ cool findings associating sex differential expression to neuropsychiatric disorders 🧠🔬🧪
www.cell.com/cell-reports...
This quantification of loss is staggering. And knowing some of the excellent people that make up these numbers… is heartbreaking
www.science.org/content/arti...
Cartoon zebrafish with green lit-up brain, in well of plate responding to hit molecule.
Drug discovery for nervous system disorders is really challenging. We think early/rapid in vivo testing with zebrafish will accelerate the drug development cycle for conserved targets. Check out our proof-of-principle pilot study and virtual drug discovery pipeline (tinyurl.com/3whr23hs). #Skytorial
#ACNP2026 was a huge success! Great location, with even better science.
Americans still have more confidence in scientists than many other groups in society
Full survey results show American public have high levels of confidence in scientists while revealing some partisan differences (including on how to fund science), but statements asserting lost trust should be read instead as intentional efforts to degrade trust.
www.pewresearch.org/science/2026...
Natalia is awesome! She’s applying to grad schools this fall and will make a great addition to any lab
Excited to be headed to my first @acnporg.bsky.social meeting! Stop by my talk to hear about D1-islands in the human NAc or my poster to hear about our efforts to use spatial transcriptomics to profile lateral septum neurons in the human brain.
Keri is not only an incredible scientist, but also an awesome mentor. So excited to see what's next for LIBD with @martinowk.bsky.social as CSO #Chief
Steve claims not to have thrown a snowball in Brad's "Annoying little face". The evidence suggests otherwise.....
Incredibly excited to and truly honored to receive a #SOBP travel award! Grateful for the opportunity and excited to attend the meeting, share my work, and connect with a new group of scientists. Looking forward to an awesome experience #SOBP2026
🧠🐭💊 Check out our work on the role of Central Amygdala cell-types in opioid withdrawal ...
Now published in Neuropsychopharmacology
@npp-journal.bsky.social
Open-access link: www.nature.com/articles/s41...
Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention.
1/7
www.biorxiv.org/content/10.6...
Also! @rehg-j.bsky.social is the talent behind the 🔬for some of my most loved #FluorescenceFriday images! He is an amazingly talented RA that is applying to grad school this cycle and has done an incredible job contributing to this project over the past two years!
New paper alert!!...🤩 Led by @blogeman.bsky.social, we identify how cell type-specific hormonal responses in the hypothalamus tunes parenting behavior in males and females 🐭🧠🍼. Highlights in thread 👇 1/6
www.biorxiv.org/content/10.6...
Viral labeling of projection neurons in the mouse brain with green fluorescence protein
For #FluorescenceFriday - experiment was apparently a stereotaxic injection "miss", but resulted in a lovely image nevertheless. Credit to @rphillips3.bsky.social and JHU undergrad Natalia Gonzalez-Perez 🧠🔬🧪
There is a correct answer here
Excited to share that our article on accurate sample deconvolution of pooled snRNA-seq data using sex-dependent gene expression patterns is live on NAR Genomics and Bioinformatics! 🎉
Check it out here: doi.org/10.1093/narg...
#NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics
Clustering of spatial gene expression from a profiled tissue section of human brain in the basal forebrain
Our lateral septum (LS) team is representing for #SfN25! We have two posters on Wed afternoon from RA Madeline Abramson (PSTR463.16) and undergraduate Yufeng Du (PSTR463.17) showcasing newest molecular profiling results across mouse, non-human primate and human 🧠
I'm there too - get in touch!
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
Congratulations to our habenula team! We've learned a lot about working in this tiny brain region. Here we characterize the molecular signatures of human habenula cell types and transcriptomic changes associated with schizophrenia. Stay tuned 👀 for more exciting habenula findings in the near future.
List of poster presentations for Saunders lab at SFN conference in November 2025.
If you're heading to #SfN25 in a couple weeks, pop in early to the posters on Saturday afternoon and Sunday morning to see a bunch of cool unpublished work from the lab.
People who know me know I rarely shill for much, but my experience at UAB as a family member of a patient was amazing. Huge thanks to Neurosurgery and Drs. Kristen Riley, Brad Woodworth, and Harrison Walker (Neurology).
smFISH for immediate early gene Fos in a section of the mouse hippocampus
For #FluorescenceFriday - simple image, but structure of hippocampus is beautiful with additional fanfare. 🟢 is Fos - labeling cells that get activated in response to disinhibition of inhibitory neuron subpopulation in the prefrontal cortex. Image credit to JHU Neuroscience student Aaron Salisbury.
Don't miss this new 🔥 Hot Topic 🔥 from @rphillips3.bsky.social & Stephanie Page 👇
