Eliseo Papa

🥁Introducing Gemini 2.5, our most intelligent model with impressive capabilities in advanced reasoning and coding.

Now integrating thinking capabilities, 2.5 Pro Experimental is our most performant Gemini model yet. It’s #1 on the LM Arena leaderboard. 🥇

Protein waste turned into antibiotics as a defence strategy of human cells Proteasome cleavage changes during infection to generate antibiotics.

Proteasomes make natural antibiotics while breaking down proteins. So cool to see research in new areas revealing another layer of biological complexity. Makes you wonder what else is out there! www.nature.com/articles/d41...

Slashed zero (0̸), a representation of the number 0 (zero) to distinguish it from the letter O Slashed letter 'O' (O̸), a representation of the letter O to distinguish it from the number 0 (zero)

Does a cell’s gene expression always reflect its function? Transcriptionally similar neurons can be functionally diverse.

nice perspective and a cool 🐟 study! www.nature.com/articles/d41...

wait it’s not hopeless?

Jeff Dean & Noam Shazeer – 25 years at Google: from PageRank to AGI YouTube video by Dwarkesh Patel

Delighted to have joined my good friend & colleague Noam Shazeer on a podcast with @dwarkesh.bsky.social for a 2+ hour discussion on early Google, ML hardware, training 1T+ token LLMs in '07, model sparsity, continual learning, and more.

Thanks, Noam and Dwarkesh! 🙏

youtu.be/v0gjI__RyCY?...

Reading group session on Monday: Valentin De Bortoli joins us for his paper "Accelerated Diffusion Models via Speculative Sampling" arxiv.org/abs/2501.05370

On zoom at 9am PT / 12pm ET / 6pm CET: portal.valencelabs.com/logg

UK's elite hardware talent is being wasted. Imperial, Oxford, and Cambridge produce world-class engineers. Yet post-graduation, their trajectory is an economic tragedy - and a hidden arbitrage opportunity.

a call to all hardware founders to build josef.cn/blog/uk-talent in the uk 👏

super cool paper!

The Fleming Initiative and Google DeepMind lay the path for AI to help tackle antimicrobial resistance A new report from the Fleming Initiative and Google DeepMind lays out a vision for the impact that an AI and data-driven approach...

We have been diving into the AMR world and it's fascinating! So many possibilities. Let's see what happens! 🧑‍🔬🧫🧪👨‍💻
www.fleminginitiative.org/post/ai-to-h...

A month ago we @vevotherapeutics.bsky.social announced that we have generated the largest single-cell perturbation atlas in history, Tahoe-100M. Today, we announce that we will fully open-source Tahoe-100M in Feb, as part of a collaboration with NVidia health to train cell state models.

Interested in building the future of open source ligand- and structure-based ML models for ADMET prediction?

The ARPA-H funded OMSF (@omsf.bsky.social) OpenADMET project is hiring multiple positions to build ML models of ADMET properties and drive informative data collection!

openadmet.org/jobs/

Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation - Nature Genetics Borzoi adapts the Enformer sequence-to-expression model to directly predict RNA-seq coverage, enabling the in-silico analysis of variant effects across multiple layers of gene regulation.

Congrats to Johannes Linder, David Kelley et al. on the journal publication of Borzoi - a long context sequence models of RNA-seq coverage profiles with many nice applications for transcriptional & post-transcriptional regulation & variant effect prediction.

www.nature.com/articles/s41... 1/

Features of Adulthood xkcd.com/3034

52 things I learned in 2024 This year I took a sabbatical, recorded a podcast with Freakonomics, designed and shipped a tiny modular synthesiser, and learned many learnings. Tom Whitwell designs open source music electronics as…

This yearly list is fantastic as usual: medium.com/@tomwhitwell...

For example:
> To highlight tax evasion, South Korea introduced ugly neon green number plates for company cars worth more than $58,000. Luxury car sales fell 27%. [Song Jung-a]

so cool, congrats 🙌

#TeamTomo is at it again. Nice look at the conformational cycle of protein folding machinery inside native human cells by the teams of Frydman & Beck 🧪🔬🧶🧬

tbf it doesn’t seem particularly strange - i glanced at the screenshot after reading this and it looks like the “top10 most popular” section of an average bookshop.

Vagrant's Vancouver | Vagrant Gautam A non-comprehensive list of places to go and things to do in the Greater Vancouver Area as curated by yours truly over 6 years. Might be outdated so please double-check!

Turned @dippedrusk.bsky.social 's amazing Vancouver list dippedrusk.com/posts/2024-0... into Google Maps pins: maps.app.goo.gl/nGBbcUAMMixC...

Lots coming for protein design!

If you will be at #NeurIPS2024 @neuripsconf.bsky.social and would like to come see our models in action, come say hi 👋 and check out our demo at the GDM booth!

Wednesday, Dec. 11th @ 9:30-10:00.

Lots of other great things to see as well! Check it out: 👇
deepmind.google/discover/blo...

Excited to reveal Genie 2, our most capable foundation world model that, given a single prompt image, can generate an endless variety of action-controllable, playable 3D worlds. Fantastic cross-team effort by the Open-Endedness Team and many other teams at Google DeepMind! 🧞

fun times!

Fair enough. I guess we'll all scramble until we find an acceptable one. It takes a while to find out what kind of interview leads to the fairest process and the best hires. Probably back to having more face time?

Some techs and modalities are massively over-represented so it becomes hard to determine if it's a problem that would stop generalization.
Reprocessing most single cell data in a single pipeline would allow to diagnose this better (and would be a phenomenal service to the sc community!)

constructing good interviews is a never ending quest - here is a quick read on how access to LLMs changes incentives segfaulte.mataroa.blog/blog/hackerr...

as a kid, i fixed my parent's computer. as an adult I fix my kids's computer. pretty sure we are the only gen that knows how computers work

hope one day to see an animation of the clockwise to counterclockwise switching mechanism :)

Taming Transformers for High-Resolution Image Synthesis Designed to learn long-range interactions on sequential data, transformers continue to show state-of-the-art results on a wide variety of tasks. In contrast to CNNs, they contain no inductive bias tha...

IMO VQGAN is why GANs deserve the NeurIPS test of time award. Suddenly our image representations were an order of magnitude more compact. Absolute game changer for generative modelling at scale, and the basis for latent diffusion models.

Promotional logo for MMseqs2 16 with the MMseqs2 Rocket mascot as a smart phone like App logo

MMseqs2 Release 16 Highlights: GPU-accelerated search📄, ORF or new 6-frame translated search modes, contig taxonomy always keeps the longest ORF, bug fixes (reduced memory and higher sensitivity) and relicensed as MIT
📄 biorxiv.org/content/10.1...
💾 mmseqs.com and 🐍Bioconda 🖥️🧬🧶