Congrats!!

Mitochondria-Lysosome Crosstalk Shapes Metabolic Transition in Neonatal Enterocytes The neonatal gastrointestinal tract mediates nutrient absorption and the establishment of immune tolerance to commensal microbiota. In early life, lysosome-rich enterocytes (LREs) in the ileum are nec...

Mitochondria-Lysosome Crosstalk Shapes Metabolic Transition in Neonatal Enterocytes
Gonzalo Herranz, et al. 2025 bioRxiv 2025.09.09.674148; doi: doi.org/10.1101/2025...

Childhood malnutrition remains a major global health challenge. Our work reveals how organelle crosstalk in neonatal gut cells safeguards nutrition and development — and how its failure resembles Kwashiorkor.

Martin-Belmonte and Martinez-Martin at CBMSO

🚨 New paper out!
Neonatal enterocytes rely on autophagy & mitophagy to sustain nutrient absorption. Our study demonstrates that the mitochondria–lysosome axis controls the weaning transition and may contribute to childhood malnutrition.
👉https://www.biorxiv.org/content/10.1101/2025.09.09.674148v3

Thank you Sofia
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Graphical model showing the effect of CASM autophagy in lumen resolution of epithelial tubes.

🧪 Canonical autophagy isn’t enough! In our new study, only CASM can coordinate the membrane remodeling needed to build a single lumen in tubes. Read how CASM drives endocytic recycling to drive morphogenesis www.biorxiv.org/content/10.1...
#ScienceTwitter #Autophagy #Morphogenesis #CellPolarity

ATG16L1 KO H1-human Neural Tube organoids fail to resolve ML at day 5 of development. Cells were stained for actin (red) and nuclei (blue). Dotted lines indicate the lumens.

🚨 New paper out! We reveal that noncanonical autophagy (CASM) is a critical driver of epithelial lumen formation. CASM regulates endocytic recycling and membrane remodeling—without it, cells can’t resolve into a single lumen.
www.biorxiv.org/content/10.1...