Our circadian clock and cancer chronotherapy, a terrific
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...

What the fuck

Tracking Social Lapwings, to understand hunting pressures on this critically endangered wader:
wadertales.wordpress.com/2021/01/03/f...
(WaderTales blog from 3 Jan 2021)
More about tracking waders:
wadertales.wordpress.com/2025/05/06/m...
#ornithology

Natural daylight during office hours improves glucose control and whole-body substrate metabolism Harmsen et al. compared the metabolic impact of natural daylight vs. artificial office lighting in individuals with type 2 diabetes over 5 days. Daylight improved glucose homeostasis, whole-body fat u...

Natural daylight and improved glucose control in Type 2 diabetes
cell.com/cell-metabol...

„Further correspondence […] indicates that the authors may have received financial compensation from Monsanto for their work on this article […]. [That] raises significant ethical concerns and calls into question the apparent academic objectivity of the authors in this publication“

„ It appears […] that employees of Monsanto may have contributed to the writing of the article […]. This lack of transparency raises serious ethical concerns regarding […] the academic integrity of the carcinogenicity studies presented.“

Regulatory Toxicology and Pharmacology ELSEVIER Volume 31, Issue 2, April 2000, Pages 117-165 RETRACTED: Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans Gary M. Williams 9 Robert Kroes °, Ian C. Munro © 2 This article has been retracted: please see Elsevier Policy on Article Withdrawal

#Oops: The seminal paper that has been used for 25 years to justify that the use of #Glyphosate is safe has been retracted.

▶️ www.sciencedirect.com/science/arti...

"Concerns were raised regarding the authorship of this paper, validity of the research findings…"

Not this again

'however, standard culture methods did not yield readily cultivable microbiota.'

Image screening is going to fail. We need audit trails for data provenance.

Interested in Python programming and good software engineering practices? Check out my newest blog post where I introduce a "modern Python" GitHub repository template and talk about my motivation for its creation! mmzdouc.github.io/posts/2025/1...

Also, if you're "in bed with flu", it's almost certainly Covid.

Mass Spec

Finally, we're looking for someone to join our #MassSpec Core Facility to support all the protein/peptide MS & development needs of our research groups utilising:

🧪Protein chemistry
📈Liquid chromatography
⚛️Tandem mass spectrometry
🖥️Data analysis

More at:
www.cruk.manchester.ac.uk/career/mi-25...

www.medschl.cam.ac.uk/characterisi...

We have a potential MRC iCASE PhD with AstraZeneca using mass spectrometric techniques to identify the destination organs of endogenous and exogenous peptide hormones. This should be a really interesting PhD, using both ours and AstraZeneca's expertise and mass spectrometry instrumentation.

Where do injected peptide weight loss drugs end up in the body? What about known and currently uncharacterised peptides produced in the gut - where do they go? Want to help myself and Andreas Dannhorn from AstraZeneca try and find out how to do this?

Birding at Hällögern; Northern Sweden; 25th September 2025 Adult White-tailed Eagle floating past my position this morning in glorious early morning light. This alone was worth the price of admission...

blogbirder.blogspot.com/2025/09/bird... The daily birding summary has just gone up on Blogbirder, for those interested in my birding efforts here on Hällögern, a tiny little island in Northern Sweden. I am posting such updates every evening for the next ten days...

If A.I. Can Diagnose Patients, What Are Doctors For? Large language models are transforming medicine—but the technology comes with side effects.

Highlighting some of the many current pitfalls of A.I. in health care
@newyorker.com
@dhruvkhullar.bsky.social
www.newyorker.com/magazine/202...

Happy International Microorganism Day #internationalmicroorganismday

Opinion | We Ran the C.D.C.: Kennedy Is Endangering Every American’s Health

Nine of the CDC directors over the past 48 years have a lot to say about what RFK Jr is doing vs health of Americans
www.nytimes.com/2025/09/01/o...

XC584201 Soundscape Crazy night at Ouessant's lighthouse in stormy conditions. Over 15 000 calls featuring at least 27 species. Many birds were circling around the lighthouse to find their way through the mist.

... a night worth sharing maybe? Like xeno-canto.org/584201 ?

A patient page for GLP-1 drugs and importance of integration of lifestyle factors with these meds
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...

The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library containing hundreds of N-acyl lipids, including conjugates with short-chain fatty acids. This resource enabled the...

If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...

Cross-organ metabolite production and consumption in healthy and atherogenic conditions An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or hypercholest...

This is such an incredible paper. Must read if you care about metabolites and cores organ interactions. For me most interesting finding is that the liver is NOT the only organ that converts cholesterol to bile acids. But ther are so many cool onserbwtions www.cell.com/cell/abstrac...

An image of an American flag flying over a hill. The words say: How to Plan a Trip to the USA. 1. Don’t.

I’ve seen a few variations of this making the rounds. I like this one best.

I don’t know who the original artist is but thank you to them.

Anyone interested in using mass spectrometry to identify and quantify peptides and proteins in plasma, tissue and organoid cell systems?

I have a Research Assistant position in my lab at the Institute of Metabolic Science - Metabolic Research Laboratories.

Apply here:

lnkd.in/dCxhS3GN

[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.

Mass Spec

xkcd.com/3094/

People Overtrust AI-Generated Medical Advice despite Low Accuracy This article presents a comprehensive analysis of how artificial intelligence (AI)–generated medical responses are perceived and evaluated by nonexperts. We conducted a study in which a total of 30...

People rate AI-generated medical answers as more trustworthy & complete—even when wrong. Low-accuracy LLM outputs were seen as valid and actionable, often indistinguishable from doctors’ advice. Unchecked trust in fluent hallucinations poses serious risks.

NEJM AI: ai.nejm.org/doi/full/10....

If there any #Sciex decision makers here on Bluesky - I urge you to reconsider. Skyline/Proteowizard support is not only important for your customers using these tools, but it also benefits other bioinformatics efforts that depend on these tools.

Empowering chemists to mine high-throughput mass spectrometry datasets - Nature Methods The Mass Query Language (MassQL) enables scientists to precisely express and reproducibly search for mass spectrometry (MS) peak patterns in large MS datasets. MassQL has been adopted across the most ...

If you're new to MassQL - definitely checkout the research briefing that describes how MassQL enables scientists to precisely express and reproducibly search for mass spectrometry patterns in large datasets:

www.nature.com/articles/s41...

and find the full article:

www.nature.com/articles/s41...

I am thrilled to share after years of work/procrastination that the MassQL manuscript is finally published in @natmethods.nature.com - "A universal language for finding mass spectrometry data patterns". This was an team effort from all co-authors that helped shape MassQL and how it could be used.