Matthias Spiller-Becker

🕰️The next session of #FragileNucleosome seminar series due to switch to daylight saving in US will start at 4pm GMT (5pm CET) time.

👇🏽👇🏽👇🏽👇🏽👇🏽
We often think of cell identity as the result of biochemical signals, soluble or membrane-bound. Join to the @fnucleosome.bsky.social seminar series if you would like to know more on how nanoscale extracellular topography can directly regulate cell identity in embryonic stem cells.

What a BANGER! Thanks so much from the aficionados!

Photograph of Alice Sherrard Text says "A very warm welcome to Dr Alice Sherrard New Group Leader Chromatin Regulation in Cancer" Background shows an electron microscope tomograph with gold labelling

We are delighted to announce that Alice Sherrard will be joining the Institute as a Group Leader in October!

Alice is an outstanding researcher with expertise in #chromatin topology & #ElectronMicroscopy, combing these with genetic models in her new research group - Chromatin Regulation in Cancer

In this episode we talked with Patrick Murphy from Cornell University about his work on Placeholder Nucleosomes to zygotic genome activation and cellular identity. #podcast #chromatin #epigenetics

Listen here: activemotif.com/podcasts-pat...

From Placeholder Nucleosomes to Zygotic Genome Activation (Patrick Murphy) Podcast Episode · Epigenetics Podcast · February 26 · 39m

Today’s guest: Patrick Murphy podcasts.apple.com/us/podcast/e...

That's...wait-a-mintue...that's you!
; )

I recently reviewed a paper where the corresponding author was SO blunt, bordering rude, & started every sentence like they hated me instead of "thank you my king for the comment", and I was like FAIR, I'm here to comment on the science, and don't have a micropenis ego that can't handle this tone.

Anyone else seeing this with H3K27ac in CUT&Tag?

Thanks a lot for sharing your experiences, Stefan! That is really weird with H3K27ac. That's the very modification I would have considered a no-brainer in no matter what assay. What are the issues? Fewer peaks, peak height, noise...all combined?

Cartoon by Mike Luckovich.

Thanks a lot for the feedback, Tim! Yes, there is a lot of potential and lot remains to be done. But have you had the need to "go back to" ChIP as well - for some targets maybe?

Hey Chromatin Friends!
Long time no chromatin question...
For many of you, CUT&x (RUN/Tag) works really well but some of you have had their frustrations with CUT and "gone back" to ChIP-Seq. Can you share your experiences in the comments!?
Would love to hear from you!
Sharing is appreciated : )

🎉 Celebrating our Amazing Women in Ageing Research! 🎉
Meet Hannah, a research group leader exploring the role of microglia in maintaining brain health, and investigating how their function changes during aging and in neurodegenerative diseases. 👩‍🔬
#WomenInScience #AgeingResearch

Congratulations to *Dr.* Ngoc Cao @ngoccao.bsky.social on a fantastic PhD defence 🥳 Stay tuned to learn more about her insightful PhD research!

Sometimes, that would be a wonderful escape...

What a blast it was to be in that very temple the first time! Think it was my favourite one - back in the blessed days of Idontgiveafuckandjustplaythisgamenow.

A very nice message being shared here! Thank you Asifa!
And love to see many familiar faces (Herbert ❤️).

Asifa Akhtar on epigenetics and closing the gender gap What is epigenetics and why do we study it? To find out, we asked Asifa Akhtar, a researcher from Karachi working at Germany’s Max Planck Society. Her work in the field is also helping close the gende...

See this 12 minute video by DW on @asifa-akhtar.bsky.social research in epigenetics and why and how closing the gender gap.

#womeninstem #womeninscience

“The only thing more consistent than PIXUL® Sonication is my feelings for you.” 💘😝

Share a Valentine and enter our Valentine’s Day Giveaway for your chance to win an ATAC-Seq Express Kit, CUT&Tag-IT® Express Kit, or TIP-ChIP™ Assay Kit. ➡️ bit.ly/4kjJUz3

💌 Giveaway ends Feb 28, 2026

#ActiveMotif

Brain with puzzle overlay to show that our study provides missing pieces of the puzzle of human brain development by delivering the most comprehensive picture of hindbrain development to date. We have strived to go beyond just another multi-omics atlas to gain deep insights by: 1. Meticulously annotating cell clusters 2. Extracting regulatory programs in terms of coordinated gene sets and accessible regulatory elements 3. Using deep learning to identify regulatory syntax 4. Resolving context-specific TF activity

Excited to share our preprint on our new multi-omic atlas of human hindbrain development. Led by postdoc Piyush Joshi, in collaboration with @kaessmannlab.bsky.social and Pfister labs, our atlas represents the first comprehensive view of human hindbrain development. www.biorxiv.org/content/10.6...

On #WorldCancerDay, we recognize the critical role epigenetics plays in advancing cancer research.
Active Motif is proud to support researchers worldwide with tools that enable deeper insight into cancer biology, including ChIP-Seq Kits & antibodies.
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#CancerResearch #Epigenetics #ActiveMotif

Why is flu so bad this year? Highly mutated variant offers answers A ferocious surge of flu cases is linked in part to a variant that has not been dominant in the past few years — resulting in a waning of natural immunity.

www.nature.com/articles/d41...

Thanks for posting, Maria! I just contributed to the case numbers so I can relate : /

Our Mini Review went online last night in Current Opinion in Genetics & Development
"Block copolymer concepts of how transcription organizes the stem cell genome"
doi.org/10.1016/j.gd...

Fig. 1: Stem cell–typical organization of the genome and transcription, and the block copolymer sorting concept.

Ibrahim Cisse, Nicola Iovino and Asifa Akhtar during the Max Planck Freiburg Christmas Apéro

Ibrahim Cisse, Nicola Iovino and Asifa Akhtar in front of the MPI-IE team during the Max Planck Freiburg Christmas Apéro on Dec. 11.

Ayele Denboba and Juliane Glaser enjoying some mulled wine

Results of our 2025 Christmas wreath competition – using only laboratory materials and equipment to create your lab christmas decoration

🎄🌟 Season’s greetings from the entire team of the Max Planck Institute of Immunobiology and Epigenetics in Freiburg … with a few impressions from our Winter Cookie Fair on December 11. ❄️

We wish you Happy Holidays and best wishes for 2026!

I need a glass of stone water to better digest this!

As 2025 comes to a close, I am realising that it has been 20(!) years since the publication of the very first article featuring me as a co-author…

In the most recent episode we talked with @epign.bsky.social from the École polytechnique fédérale de Lausanne about her work on transgenerational inheritance in Drosophila and brain organoids for human development insights. #podcast #epigenetics

Listen here: activemotif.com/podcasts-fid...

In this episode we talked with @epign.bsky.social from the École polytechnique fédérale de Lausanne about her work on transgenerational inheritance in Drosophila and brain organoids for human development insights. #podcast #epigenetics

Listen here: activemotif.com/podcasts-fid...