My analysis of excess deaths with fenebrutinib in the FENhance 1/2 and FENtrepid trials suggests this would be extremely unlikely to occur by random chance. By X^2, p-value is 0.0016. By Fisher exact, p ~ 0.0019. But why?
Multiple Sclerosis & Kappa Free Light Chains Explained youtu.be/6HN4HKfj5NE?...
Ich habe wirklich keine Ahnung, woran das liegen kΓΆnnte....
/s
![chronic illness be like time for breakfast [person holding all their prescriptions in their ahnd]
unchargeables](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:dbzmdmsaz6lkhb4tv3culzme/bafkreiftmluiglz7job57mx5bpqbcregbsj3gzijcfblkn4xcoj4lwvzdy)
chronic illness be like time for breakfast [person holding all their prescriptions in their ahnd] unchargeables
Never tell me to "trust my body" because as someone with multiple autoimmune disorders, that's actually the last thing I'm ever gonna do
A case report of visceral leishmaniasis (a very rare parasitic infection) in a 56 year old man taking gilenya for multiple sclerosis with a low lymphocyte count of 330/ΞΌL revespquimioterapia.com/articulo/vis...
serum neurofilament light chain (a marker of central nervous system injury in multiple sclerosis) does not correlate with "no evidence of disease activity" (NEDA-3) in people who are taking disease modifying therapy. link.springer.com/article/10.1...
Dr. Amit Bar-Or summarizes the primary results from the Phase III FENtrepid study of fenebrutinib versus ocrevus in primary progressive MS youtu.be/o3sxq3rnpsA?...
FENtrepid (Fenebrutinib vs. ocrevus in PPMS). compositive disability similar. nonsignificant trend favoring fenebrutinib. HR: 0.88 (95% CI 0.75β1.03)
Data driven mostly by timed 25-foot-walk.
9-hole peg test favored fenebrutinib (26% less progression) assets.roche.com/f/176343/x/4...
It is a pity we didn't do it before the new McDonald diagnostic criteria were developed. The process is underpinned by Viquar Chamoun's work on neurosarcoidosis as part of his MD.
Beyond the 2024 McDonald Criteria for Defining and Diagnosing Multiple Sclerosis buff.ly/u6HBOkS
Liver enzymes in the FENtrepid Trial (fenebrutinib vs. ocrevus in primary progressive MS). Much more liver enzyme elevation with fenebrutinib as expected, though all cases resolved after stopping the drug and none lead to permanent liver failure. assets.roche.com/f/176343/x/4...
Deaths in the FENtrepid Trial (fenebrutinib vs. ocrevus in primary progressive MS). 7 deaths with fenebrutinib vs. only one with Ocrevus. Concerning, but there is no specific pattern. assets.roche.com/f/176343/x/4...
Es ist unbegreiflich. Die Energiewende funktioniert. Wir werden zunehmend autonom in unserer Stromproduktion. Es entstehen hunderttausende neue ArbeitsplΓ€tze. Wir erreichen damit unsere Klimaziele.
All das will Reiche anscheinend nicht. TRAURIG!
"Ich bin 63. Ich habe nicht mehr lange auf diesem Planeten.
Aber ich bin besorgt um mein eigenes Leben. Und ihr solltet es auch sein." - Prof Hugh Montgomery
Britische Experten warnen eindringlich, dass die Auswirkungen der #Klimakatastrophe uns hΓ€rter & frΓΌher als erwartet treffen
#Klimakollaps
The Immune System and MS
1/
Multiple Sclerosis is an autoimmune disease.
This means the immune system mistakenly attacks the bodyβs own tissues.
MS Is a Brain Disease
1/
Multiple Sclerosis is not primarily a muscle disease.
Itβs a brain and spinal cord disease.
Covid-19 in der Woche 3.3.-9.3.26: krΓ€ftigβοΈ
FΓ€lle: -40%, RβοΈ0,74
Inzidenz:
FΓ€lle inkl. DZF 60: 71βοΈ42
Abwasser: 70-90βοΈ40-70
Grippeweb: ~50β‘οΈ~50
... plus [KW7]: 400βοΈ~450βοΈ
Hospitalisierung: 75βοΈ44, R_14TQ: 0,88βοΈ0,79
ITS_Belegung (7TM): 37βοΈ25, R: 0,84βοΈ0,89
Infiziert: 1 von ~1650.
Γzdemir macht Lehrerin, die Manuel Hagel den Wahlkampf versaut hat, zur Bildungsministerin www.der-postillon.com/2026/03/bild...
Landtagswahl in Baden-WΓΌrttemberg AfD verdoppelt ihr Ergebnis beinahe Stand: 08.03.2026 β’ 22:08 Uhr Geht es nach den Gewinnen und Verlusten bei den Stimmanteilen ist die AfD die klare Siegerin der Landtagswahl. Die Partei feiert ihren Erfolg, auch wenn es wohl weiterhin nichts wird mit einer Regierungsbeteiligung. Die AfD hat sich klar den dritten Platz bei der Landtagswahl in Baden-WΓΌrttemberg gesichert. Zwar liegt sie Hochrechnungen zufolge deutlich hinter den GrΓΌnen und der CDU - hat aber gleichzeitig einen groΓen Vorsprung auf die SPD und konnte vor allem bei Arbeiterinnen und Arbeitern punkten.
Siegerin der Herzen in der Tagesschau-Redaktion.
www.tagesschau.de/inland/landt...
"I don't know how u deal with being sick all the time." easy. there's no other option. mybodyistryingtokillme.com
In this mouse model of multiple sclerosis (EAE Study) Ξ±4Ξ²7-blocking antibodies (DATK 32) were successful at reducing severity even though they selectively block lymphocyte entry in the gut and not the CNS (unlike tysabri/tyruko) pubmed.ncbi.nlm.nih.gov/31597098/
For many people living with MS, overstimulation β noise, bright lights, crowds, or too much multitasking β can increase symptom intensity.
Fatigue, brain fog, and sensory overload can become stronger when the nervous system is overwhelmed.
Checking your blood to check your MS
open.substack.com/pub/edtobias...
A study on the central vein sign and paramagnetic rim lesions in Asian people with multiple sclerosis shows similar data to other ethnicities. PRL 100% specific but only present in 63% with MS. 6 or more central veins 69.1% sensitivity/98.1% specificity pubmed.ncbi.nlm.nih.gov/41755542
FEBRUARY 2026 LIVE STREAM NOW! ASK ME ANYTHING MULTIPLE SCLEROSIS! by @aaronbostermd.bsky.social www.youtube.com/live/gvsnk3F...
Upcoming Videos:
3/4/26: The Irony of Dr. Terry Wahls
3/11/26: Kappa Free Light Chains
3/18/26: Lucid MS
3/25/26: MS Drug Overview www.youtube.com/@DrBrandonBe...
A fierce debate about MRI negative relapses in multiple sclerosis. 77.3% of relapses in the ULTIMATE I/II trial where were briumvi-treated group did not have brain MRI changes. These authors believes some of these events are progression or pseudorelapses. journals.sagepub.com/doi/10.1177/...
