Ozge Gunduz-Cinar

Astrocytes enable amygdala neural representations supporting memory - Nature Astrocytes in the basolateral amygdala dynamically track fear state and support fear memory retrieval and extinction.

Congratulations to Olena Bukalo and Holmes Lab for this fantastic paper!

www.nature.com/articles/s41...

Gunduz-Cinar and colleagues’ study on dopamine neurons and fear extinction serves as a model for advancing science through transparency about null results.
https://blog.eneuro.org/2025/10/editors_pick_khokhar

thank you @sfnjournals.bsky.social

#eNeuro: @ozgegunduzcinar.bsky.social et al. show that activity of midbrain dopamine neurons fails to show normal dynamic changes during fear extinction in a rodent model of impaired extinction. https://doi.org/10.1523/ENEURO.0174-25.2025

Just saw this:

blog.eneuro.org/2025/10/edit...

@sfnjournals.bsky.social

4/4

Our findings suggest that alterations in the VTA-dopamine dynamics during exposure therapy may explain why individuals don’t respond well to therapy and remain fearful. Thank you to all authors: Eva Maria Fritz, Maya Xia Elise Van Leer Nevin Crow, Holmes & Singewald labs #eNeuro thank you!

3/4

Using a mouse model, we found that a brain region called the ventral tegmental area (VTA), which produces the brain chemical dopamine, shows abnormal activity when fear responses should normally decrease.

2/4

We explored why some people have difficulties in overcoming their traumatic fear despite the exposure-based cognitive behavioral therapy.

Altered Dopamine Signaling in Extinction-Deficient Mice A central mechanism of exposure-based cognitive behavioral therapy for anxiety and trauma-related disorders is fear extinction. However, the mechanisms underlying fear extinction are deficient in some...

1/4 New Paper 🧠🐭 #Neuroscience #Dopamine #FearExtinction
#eNeuro
Altered Dopamine Signaling in Extinction-Deficient Mice www.eneuro.org/content/12/1...

🚨 Save the Date! 🚨
The MACRC 2025 Conference — the first official ICRS Chapter meeting 🍃
📅 Nov 14–16, 2025 | 📍 Kitty Hawk, NC
Abstracts & registration open (early bird thru Sept 21)!
👉 www.m-acrc.org

#CannabinoidResearch #MACRC2025 #ICRS

Endocannabinoids facilitate transitory reward engagement through retrograde gain-control Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting as a crucial tuning factor to influence neuronal activity by dynamically shaping excitatory and inhibitory f...

I’m excited to share the most recent study from the Bruchas
lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system!

www.biorxiv.org/content/10.1...