María A. Moro (@mariangelesmoro)

Tanycytic degeneration impairs tau clearance and contributes to Alzheimer’s disease pathology Tau protein accumulation in the brain is a sign of Alzheimer’s disease. In this study, Prevot and colleagues show that specialized hypothalamic cells called tanycytes clear tau by shuttling it from th...

www.cell.com/cell-press-b...

09.03.2026 20:18 👍 1 🔁 0 💬 0 📌 0

Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction Self-amplifying RNA (saRNA) enables sustained protein expression from a single administration. In this study, we developed an intramuscular saRNA-lipid nanoparticle (saNppa-LNP) therapy encoding natri...

www.science.org/doi/10.1126/...

07.03.2026 06:26 👍 0 🔁 0 💬 0 📌 0

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature Liver exercise factor GPLD1 rejuvenates blood-brain barrier integrity and reverses cognitive impairments in aging and Alzheimer’s disease models by targeting GPI-anchored proteins on brain endothelial...

www.cell.com/cell/fulltex...

06.03.2026 08:07 👍 2 🔁 0 💬 0 📌 0

Two decades of induced pluripotent stem cell research: From discovery to diverse applications Since the discovery of induced pluripotent stem cells (iPSCs) 20 years ago, iPSC technology has transformed stem cell research and regenerative medicine. This perspective reviews key advances in repro...

www.cell.com/cell-stem-ce...

06.03.2026 07:56 👍 0 🔁 0 💬 0 📌 0

Harnessing skull immunity for brain drug delivery Therapeutic delivery to the brain after stroke is limited by the blood-brain barrier. In this issue of Cell, Gao et al. bypass this obstacle by harnessing skull bone marrow immune cells to deliver dru...

www.cell.com/cell/abstrac...

06.03.2026 06:21 👍 1 🔁 1 💬 0 📌 0

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

www.nature.com/articles/s41...

05.03.2026 13:38 👍 0 🔁 0 💬 0 📌 0

Immune cells from the gut drive development of Parkinson’s disease in the brain In ‘body-first’ Parkinson’s disease, misfolded proteins propagate from the gut’s nervous system to the brain. Immune-cell activity seems to play a key part in this spread.

www.nature.com/articles/d41...

05.03.2026 13:38 👍 0 🔁 0 💬 0 📌 0

Phagocytosis and neuroinflammation: orchestrating central nervous system homeostasis, repair, and the resolution of inflammation The ingestion of foreign material—phagocytosis—is a fundamental feature shared across phyla, from single-celled ameba to more complex mammalian cells. Phagocytosis is a crucial process for maintaining...

www.cell.com/trends/neuro...

03.03.2026 20:43 👍 2 🔁 0 💬 0 📌 0

Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia - Nature Aging Lin et al. identify a mechanism by which swimming exercise attenuates cognitive decline in Alzheimer’s disease mice, via induction of skeletal muscle-derived vesicles containing miR-378a-3p, taken up ...

www.nature.com/articles/s43...

03.03.2026 20:40 👍 0 🔁 0 💬 0 📌 0

Obesity as a catalyst for neurodegeneration - Nature Metabolism In this Perspective, mechanisms by which overnutrition and obesity contribute to neurodegeneration are discussed.

www.nature.com/articles/s42...

02.03.2026 07:16 👍 1 🔁 0 💬 0 📌 0

Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease - Nature Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.

www.nature.com/articles/s41...

26.02.2026 08:49 👍 0 🔁 0 💬 0 📌 0

Forecasting the Burden of Cardiovascular Disease and Stroke in Women in the United States Through 2050: A Scientific Statement From the American Heart Association | Circulation BACKGROUND: Forecasts for the future prevalence of cardiovascular disease and stroke are crucial to guide efforts to improve health outcomes across the life course for women. METHODS: Using historic...

www.ahajournals.org/doi/full/10....

26.02.2026 08:45 👍 0 🔁 0 💬 0 📌 0

Obesity-induced inflammation: connecting the periphery to the brain - Nature Metabolism Le Thuc and García-Cáceres discuss the effect of obesity-induced systemic inflammation on the brain, including hypothalamic circuits for whole-body energy homeostasis as well as cognitive function.

www.nature.com/articles/s42...

23.02.2026 22:12 👍 1 🔁 0 💬 0 📌 0

A mouse circadian proteome atlas Otobe et al. build a searchable web tool to explore spatiotemporal profiles of about 19,000 proteins across 32 tissues and brain regions, revealing circadian protein and phosphorylation rhythms in who...

www.cell.com/molecular-ce...

23.02.2026 07:22 👍 2 🔁 0 💬 0 📌 0

Immune dysfunction in Alzheimer disease - Nature Reviews Neuroscience The importance of peripheral immunity in Alzheimer disease has gained much traction in recent years, mainly due to multiple genome-wide association studies identifying risk loci associated with genes ...

www.nature.com/articles/s41...

23.02.2026 06:53 👍 3 🔁 0 💬 0 📌 0

The brain–heart axis: effects of cardiovascular disease on the CNS and opportunities for central neuromodulation - Nature Reviews Neuroscience Maladaptive central autonomic remodelling that occurs in response to heart failure and hypertension drives sympathetic overactivity and cardiac dysfunction. In this Review, van Weperen and Vasegh...

www.nature.com/articles/s41...

23.02.2026 06:50 👍 2 🔁 0 💬 0 📌 0

A triple-node heart-brain neuroimmune loop underlying myocardial infarction This study explores the dissection of a neuroimmune pathway involving the sensory vagus nerve, the hypothalamic paraventricular nucleus, and the sympathetic superior cervical ganglia underlying myocar...

www.cell.com/cell/fulltex...

19.02.2026 04:49 👍 2 🔁 0 💬 0 📌 0

JCI - The promise of GLP-1 receptor agonists for neurodegenerative diseases

www.jci.org/articles/vie...

16.02.2026 17:58 👍 1 🔁 0 💬 0 📌 0

Será un placer estar el 11 de mayo en mi ciudad, Madrid, para hablar sobre:
“Explorando la intersección cerebro-microbioma: claves para una salud integral”
Gracias @fundacionareces.bsky.social @sebbm.bsky.social por la invitación.
¡Nos vemos allí!

14.02.2026 10:55 👍 4 🔁 2 💬 0 📌 0