Mickey Kosloff

Engineering synthetic phosphorylation signaling networks in human cells Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phos...

🚨NEW PUBLICATION ALERT🚨: In a paper out now in
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....

At the ICRP2024 meeting, quite the impressive venue and cool science in Interlaken, Switzerland

indico.psi.ch/event/15612/

Google DeepMind releases code behind its most advanced protein prediction program Six months after backlash, AI company fulfills pledge to make AlphaFold3’s full computer model available for noncommercial use

The AF3 code is (finally) up - should have been 6 months ago - but better late than never!

www.science.org/content/arti...

How Margaret Dayhoff Brought Modern Computing to Biology The pioneer of bioinformatics modeled Earth’s primordial atmosphere with Carl Sagan and made a vast protein database still used today

Preparing for a brand new biochemistry course for 1st year bioinformatics BSc students 🧬 🖥️

They will learn bioinformatics in a world were massive and easily accessible sequence databases is the norm, but should still learn about the work by Margaret Dayhoff

www.smithsonianmag.com/science-natu...

CASP16 will start later this year, so to celebrate that here is a short thread on the uncanny valley separating experimental structures & computational models of proteins. Even though the latter are extremely accurate, there are still some weird differences that are hard to pin down.  🧪🧶🧬🧵