Special thanks to all co-authors and collaborators at OSU and Wisconsin, including @judisimcox.bsky.social , for their valuable contributions.
www.biorxiv.org/content/10.1...
In intestinal organoids, SCD inhibition disrupts lipid metabolism, elevates ER stress, and reduces proliferation, effects rescued by oleic acid. In vivo, Scd1/2 loss may be compensated by dietary lipids, but under nutrient stress or DSS-induced injury, regenerative capacity can become compromised.
Excited to share new work led by outstanding former grad student Kübra Akkaya! We show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell proliferation by balancing fatty acids, sustaining epithelial homeostasis and regeneration.
excited to share a new preprint from our lab! led by the outstanding (& newly minted PhD) @thebiokimist.bsky.social we first uncover a basis for conditional HK2 essentiality in HPLM - leveraging this dependence then leads us to distinct rationale underlying why the Warburg Effect is beneficial!
Good Sunday, all. What a wonderful collection of papers in #cancermetabolism and #mitochondrialbiology this is! Check it here: biomed.news/bims-camemi/... @biomednews.bsky.social
Happy holiday season to you all!
"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski
Thrilled to see this paper out!! 🧪
Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors!
Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social!
rdcu.be/d33uQ 🧵
Congrats @brunetlab.bsky.social!!
Pleased to announce the publication of our new manuscript, "Late-life protein or isoleucine restriction
impacts physiological and molecular
signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk
