Hannah Trost

A reminder to register for the 2026 GRS meeting taking place from Feb 28-Mar 1 in Ventura, CA!

2026 DNA Damage, Mutation and Cancer (GRS) Seminar GRC The 2026 Gordon Research Seminar on DNA Damage, Mutation and Cancer (GRS) will be held in Ventura, California. Apply today to reserve your spot.

🧬Register for the GRS on DNA Damage, Mutation & Cancer🧬
Feb 28–Mar 1 2026, Ventura CA
Accepting abstracts for oral presentations! 
📍 Apply here 👉 grc.org/dna-damage-mutation-and-cancer-grs-conference/2026 (www.grc.org/dna-damage-m...)
#DNADamage #GRC#GRS #CallForAbstracts

L1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements https://www.biorxiv.org/content/10.1101/2025.09.17.676864v1

L1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements LINE-1 retrotransposition is common in human cancers and rearrangements at insertion sites can contribute to cancer-driving oncogene amplifications and promote genome instability. However, the mechani...

Check out our pre-print: We show that L1 insertion intermediates can recombine with one another or with DNA breaks to form genome rearrangements, highlighting the risk of L1 retrotransposition generating substrates for aberrant recombination and genome instability.

www.biorxiv.org/content/10.1...

Annual H&M botanical gardens photo at the GRC @cisnerosmetztli.bsky.social

Very happy to have had the opportunity to give my poster at the GRC this year! Had a lot of great discussions and questions.

Trump administration orders sweeping freeze of federal aid In a two-page memo, the Office of Management and Budget ordered all federal agencies to temporarily suspend payments.

Have they completely lost their mind? A freeze to all federal spending. Just a blanket statement with no details? As if no one is depending on this funding. Upending 95% of the government and economy to get rid of the 5% that triggers them on their revenge tour

www.politico.com/news/2025/01...

Scientists at NIH can’t purchase supplies for their studies after Trump administration pauses outside communications | CNN Scientists at the National Institutes of Health have been told the communications pause announced by the Trump Administration earlier this week includes a pause on all purchasing, including supplies f...

Instead of lowering prices, the Trump Administration is disrupting the work of researchers who are studying life-saving medicines and treatments.

Now more than ever it's important for communities that support science to band together. The future of cancer health disparity research in the US is in jeopardy. If you're interested in connecting to other disparities researchers on bsky, I can add you to this starter pack 💪🧬🩸💉🔬

go.bsky.app/HyLFqvg

Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon

Check out our latest pre-print: we show that the LINE-1 retrotransposon is a potent source of chromosomal rearrangements and instability in addition to insertional mutagenesis using shotgun and long-read WGS.

www.biorxiv.org/content/10.1...

Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon https://www.biorxiv.org/content/10.1101/2024.12.14.628481v1

Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions Repeat-mediated deletions (RMDs) are a type of deletion rearrangement that utilizes two repetitive elements to bridge a DNA double-strand break (DSB) …

So excited to see the second piece of my PhD project out 🥳

www.sciencedirect.com/science/arti...

Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions Repeat-mediated deletions (RMDs) are a type of deletion rearrangement that utilizes two repetitive elements to bridge a DNA double-strand break (DSB) …

New study from the lab @hannahtrost.bsky.social Functions of PMS2 and MLH1 important for regulation of divergent repea... www.sciencedirect.com/science/arti...

Come join us in Ventura at the 2025
@GordonConf
GRS on Mammalian DNA Repair on Feb 1-2! Spots are filling up fast!! Talks selected from submitted abstracts
grc.org/mammalian-dn...

Hi BlueSky! It's great to be here. Here's a handy Starter Pack of DNA repair & genome stability groups that I found so far go.bsky.app/NvFWKvL