bioRxiv Genetics

Cultural norms of exogamy and mobility shape hunter-gatherer genetic evolution https://www.biorxiv.org/content/10.64898/2026.03.10.710787v1

Phenome-wide genetic framework to identify mechanisms of social effects https://www.biorxiv.org/content/10.64898/2026.03.10.710784v1

Distinct cellular DNA methylation mechanisms underlie common and rare genetic risk for brain disorders https://www.biorxiv.org/content/10.64898/2026.03.09.710649v1

Loss-of-function phenomics, ncORFs, and ambiguity of mutant phenotypes in Medicago truncatula https://www.biorxiv.org/content/10.64898/2026.03.07.710271v1

Downregulation is the dominant effect of new regulatory mutations in a fungal pathogen https://www.biorxiv.org/content/10.64898/2026.03.06.710201v1

Distinct genetic architecture of gene and isoform level QTL in the Diversity Outbred (DO) mouse population https://www.biorxiv.org/content/10.64898/2026.03.06.710203v1

Blood biomarkers and breed genetics of aging in pet dogs https://www.biorxiv.org/content/10.64898/2026.03.07.710297v1

Recessive POPDC1 Truncation Causes Lethal Short-QT Pattern Arrhythmogenic Cardiomyopathy with Multi-Ion Channel Remodeling and Ankyrin-G Scaffold Disruption https://www.biorxiv.org/content/10.64898/2026.03.07.710328v1

Uncovering genetic mechanisms underlying trait variation in switchgrass using explainable artificial intelligence https://www.biorxiv.org/content/10.64898/2026.03.06.710154v1

A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination https://www.biorxiv.org/content/10.64898/2026.03.06.709695v1

A mouse model of autosomal dominant spastic ataxia and myopathy caused by a mutation in Tuba4a https://www.biorxiv.org/content/10.64898/2026.03.06.710113v1

Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects https://www.biorxiv.org/content/10.64898/2026.03.06.710116v1

Heat stress-induced condensation of G3BP1 in perinuclear P-bodies in C. elegans' germline https://www.biorxiv.org/content/10.64898/2026.03.05.709961v1

Circadian Dysregulation in Aging Alters Senescence and Inflammatory Pathways in a Sex- and Time-of-Day Dependent Manner https://www.biorxiv.org/content/10.64898/2026.03.05.709919v1

Sequence effects on patterns of variation and DNA strand asymmetries observed from whole-genome sequenced UK Biobank participants https://www.biorxiv.org/content/10.64898/2026.03.06.710079v1

AAV-Mediated Dual-Gene Therapy Restores Metabolic Function in Mice with Propionic Acidemi https://www.biorxiv.org/content/10.64898/2026.03.06.709717v1

Identification of a miRNA signature for schizophrenia in plasma-derived extracellular vesicles https://www.biorxiv.org/content/10.64898/2026.03.06.710021v1

Discovery of a Genetic Toxin-Antidote System in Vertebrates https://www.biorxiv.org/content/10.64898/2026.03.04.709565v1

Optimal spatial release strategies for confined gene drives and Wolbachia https://www.biorxiv.org/content/10.64898/2026.03.04.709515v1

Comprehensive genomic identification and multi-tissue transcriptomic profiling of vitamin D3-related genes in Atlantic salmon (Salmo salar) https://www.biorxiv.org/content/10.64898/2026.03.03.709343v1

Massive-scale single-nucleus multi-omics identifies novel rare noncoding drivers of Parkinson's disease https://www.biorxiv.org/content/10.64898/2026.03.05.709922v1

Repetitive DNA shapes genome architecture and chromosomal diversification in birds of prey https://www.biorxiv.org/content/10.64898/2026.03.03.709396v1

The chromatin remodeling complex PRC2 safeguards cell fate in alveolar epithelial type 2 cells https://www.biorxiv.org/content/10.64898/2026.03.03.708777v1

Distinct mechanisms of CNV formation at the human 15q13.3 locus https://www.biorxiv.org/content/10.64898/2026.03.03.709017v1

Centromeres are hotspots of cytosine methylation epimutations in a filamentous fungus https://www.biorxiv.org/content/10.64898/2026.03.03.709258v1

ggDNAvis: a ggplot2-based R package for creating high-quality DNA sequence and modification visualisations https://www.biorxiv.org/content/10.64898/2026.03.02.708895v1

A screen for stress-induced sleep genes in C. elegans reveals a role for glutamate signaling https://www.biorxiv.org/content/10.64898/2026.03.02.709123v1

Large-scale Perturbation of Systems Biology-Derived Genes Reveals Modifiers of HD-associated Transcriptomic Networks and Pathology https://www.biorxiv.org/content/10.64898/2026.03.02.709091v1

A flexible diet platform for the nutrigenomic screening of Drosophila disease models https://www.biorxiv.org/content/10.64898/2026.03.01.708389v1

Structural variants contribute substantially to complex trait heritability https://www.biorxiv.org/content/10.64898/2026.02.28.708732v1