Roisin OFlaherty

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibitin....

Delighted to share our latest publication in Advanced Science, where we show that hypersialylation is a key feature of intervertebral disc degeneration and that inhibiting this glycosylation change can modulate inflammatory and metabolic pathways.

doi.org/10.1002/advs...

Proud moment too — this is the first first-author paper from my PhD student, Andreea Cislaru! 🎉

🚨 New paper in Glycobiology! 🚨
Thrilled to share our latest work on serum glycosylation in nephropathic cystinosis and the understudied IgG glycosylation in juveniles.

Read it here: academic.oup.com/glycob/artic...

#Glycoscience #Glycobiology #RareDisease #Biomarkers #TeamMaynooth