Loïc Guillot

The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity Genes & Immunity - The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity

👏 J. Bigot & V. Balloy @CRSA-paris.bsky.social @sorbonne-universite.fr @hopital-stantoine.bsky.social, R. Legendre & C. Chica @Pasteur.fr + team
🫁 New insights into innate immune memory in lung epithelium #Flagellin 🦠
🙏 @vaincrelamuco.bsky.social & Fondation Air Liquide for support 🔬📄 👉 rdcu.be/eHY

Allergic bronchopulmonary aspergillosis in cystic fibrosis: Case-control study from the French registry Abstract. Allergic bronchopulmonary aspergillosis (ABPA) is a significant complication in people with cystic fibrosis (pwCF), driven by hypersensitivity to

Our last study about #aspergillus ABPA in #cysticfibrosis: Case-control study from the French registry academic.oup.com/mmy/article/...
@crsa-paris.bsky.social @inserm.fr @fac-sante-sorbonne.bsky.social thanks @vaincrelamuco.bsky.social for funding 🙏

Illustration of lungs, half is red and other half is blue. The patients in the background are also either blue or red. The lungs is surrounded by epithelial cells and #SARS-COV2. A volcano plot is emerging out from the centre #sciart #Scicomm #medsky #Biosky #COVID

Our proposed #coverart for a new study in @cp-iscience.bsky.social, from the labs of @loicguillot.bsky.social ky.social and @olivierterrier.bsky.social 🧪

📖 Full paper: lnkd.in/dSfrd8Z5

#biosky #medsky #lunghealth #COVID #Cysticfibrosis #chronicobstructivepulmonarydisease #sciart #scicomm

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

A previously unknown immunological function of the proteasome is its ability to release bactericidal compounds. This discovery presents a potential paradigm shift in antimicrobial therapy. It may contribute to addressing the global challenge of #AMR.

www.nature.com/articles/s41...

Image of Francis Collins, with text at the top of the image that says Speaker Announcement and at the bottom that says Stand Up for Science, March 7th, 2025 and a link to standupforscience2025.org.

STAND UP FOR SCIENCE SPEAKER ANNOUNCEMENT! ☀️

Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th!

More speaker announcements coming soon, stay tuned! 👀☀️

Divergent responses to SARS-CoV-2 infection in bronchial epithelium with pre-existing respiratory diseases Pre-existing respiratory diseases may influence coronavirus disease (COVID-19) susceptibility and severity. However, the molecular mechanisms underlying the airway epithelial response to severe acute ...

Glad to share our work about SARS-COV-2 epithelial response according to pathological origin #CF #COPD with @olivierterrier.bsky.social Simon Rousseau @mcgill.ca & co! Grateful for the support from @sorbonne-universite.fr & Air Liquide foundation. @cnrs.fr @inserm.fr www.cell.com/iscience/ful...

Great to share our last collaborative work on trained immunity in bronchial cells. Bravo Jeanne Bigot @crsa-paris.bsky.social @sorbonne-universite.fr Rachel Legendre @pasteur.fr 🧪

Fungal biofilms in human health and disease Nature Reviews Microbiology, Published online: 05 February 2025; doi:10.1038/s41579-025-01147-0Fungal biofilms encompass a wide range of diseases with increasing clinical impact. In this Review, Ramage et al. discuss the clinical importance of fungal…

New online! Fungal biofilms in human health and disease

Le CRSA change de tête: Félicitations à @loicguillot.bsky.social et Xavier Houard, nos nouveaux directeurs !

One Health: EU agencies unite to tackle azole fungicide resistance in Aspergillus fungi | European Medicines Agency (EMA) The extensive use of azole fungicides (azoles), particularly in some agricultural and horticultural practices, can increase the risk of Aspergillus fungi developing resistance to essential antifungal ...

Widespread use of azole fungicides in agriculture may reduce the effectiveness of antifungal treatments for patients with aspergillosis. EMA highlights that nearly all 120,000 tonnes of azoles sold in the EU were used as pesticides, potentially contributing to #AMR

www.ema.europa.eu/en/news/one-...

Job alert! post-doctoral position on #macrophages biology to study the role of a post-translational modification in inflammation and ROS production with Tarik Issad's team @institutcochin.bsky.social in #Paris! Please apply on the @cnrs.bsky.social website: emploi.cnrs.fr/Offres/CDD/U...

Highlights

#MedSky🧪 #IDsky #publichealth @thelancet.bsky.social Multidrug resistant Gram-ve bacterial infections cause significant morbidity & mortality globally. A new diagnostic & antibiotic Tx provide hope that we can better address this important #globalhealth issue.

www.sciencedirect.com/science/arti...

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.

🙏 to @niaidnews.bsky.social, first author @pauljbaker.bsky.social and my amazing lab team, our collaborators @kerryhilligan.bsky.social @danbarberphd.bsky.social 🙏to editor extraordinaire @hannah-isles.bsky.social and the reviewers who guided us along the way 9/9
www.science.org/doi/10.1126/...

Harnessing neutrophils to enhance efficacy of host-directed therapy in pneumococcal pneumonia: www.mucosalimmunology.org/article/S193...

Evaluating the association between the introduction of mandatory calorie labelling and energy consumed using observational data from the out-of-home food sector in England - Nature Human Behaviour The introduction of mandatory calorie labelling in out-of-home food outlets in England was not associated with a reduction in calories purchased or consumed. There was a post-policy increase in self-r...

Does calorie labeling change food/energy consumption?
Not in this new open-access report
www.nature.com/articles/s41... @naturehumbehav.bsky.social

The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?

direct.mit.edu/qss/article/...

A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub

🆕 Few thoughts we wanted to share with the community to look at 🍄 #aspergillosis diagnosis from a different perspective when we are still struggling on the topic.

w/ @simonfeys.bsky.social @agocarvalho.bsky.social & cie

Actively working on more answers. Stay tuned.

👉 doi.org/10.1016/j.cm...

A schematic of a macrophage detailing glycolysis pathways in homeostasis and during allergic airway disease.

Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen: www.mucosalimmunology.org/article/S193...

St. Jude Is Hiring | Join Our Mission | St. Jude Careers Explore job opportunities at St. Jude Children’s Research Hospital. Career opportunities exist in the areas of science, clinical care, operations, and more!

Do you know an experienced immunologist who is interested in studying human #immune development with next-generation methods? My lab is #hiring! Great pay, job stability, and a great place to work! Please share widely talent.stjude.org/careers/jobs...

mBio Formatting Information Overview of types of content published in mBio

🦠🧬🧫 Reminder that mBio publishes review articles and perspectives. If you have an idea in any area of microbiology or infection immunology, message me. No publication charge. Support Amer Soc Micro rather than a for-profit publisher! 📑💰 journals.asm.org/journal/mbio...

Please Tobias add me @loicguillot.bsky.social