If I have to explain to you why it's a bad idea to use a machine that makes shit up 15-80% of the time AND destroys the environment AND contributes to rising fascism and genocide AND puts brilliant skillful creatives out of work by stealing their work, then we're already speaking different languages
Final call to join us the Munich Symposium on Generative AI in Molecule Discovery, for a day full of insights and networking opportunities, at our brand-new β¨ Conference Center @www.helmholtz-munich.de
Check our agenda and secured your spot before June 24: events.hifis.net/event/2015/
Last days to register! Come and join us at the Symposium!
"Life is the shape it is for a purpose
And when you see how things really are
all the hurt and the waste falls away.
What's left is the beauty" Rosalind Franklin, in the "Life Story" movie (1987), especially recommended watching for early career scientists.
vimeo.com/179934156?&l...
Dark academia: spending a lot of time in the microscopy room as a grad student
Save the date for the Helmholtz Munich AI for Health Symposium 2025, devoted to the topic of Generative AI in Molecule Discovery!
July 4, 2025
Helmholtz Munich Campus in Neuherberg, Germany
What now?
Register and submit abstracts (deadline May 2, 2025!)
events.hifis.net/event/2015/r...
method summary
results summary
Use reward-guided generation and iterative refinement to steer the proteins generated from EvoDiff!
arxiv.org/abs/2502.14944
Programming languages named after people:
Ada, after Ada Lovelace
Haskell, after Haskell Curry
Bourne and Korn shells, after their inventors
Pike, after Rob Pike
Wolfram, after Stephen Wolfram
Julia, after no one in particular
Erlang, after Agner Erlang
Pascal, after Pedro Pascal
Hearing from Community Partners International, which works from Myanmar to Bangladesh, that USAID cuts mean 14,000 people with HIV losing access to lifesaving meds and a total stop in all HIV and TB screening. So many people will die due to these chaotic, sudden, horrifically implemented cuts.
Here I react to the shameful encounter between American leaders and media and the Ukrainian president. No doubt there were more, but I saw five failures on our side: of hospitality, decency, democracy, strategy, and independence. Please watch and share.
snyder.substack.com/p/five-failu...
All probationary federal employees at NOAAβs EMC thatβs responsible for keeping all US weather model systems running have been fired with 1 hours notice. And that includes me and colleagues. We will not go quietly because we care about the NOAA mission to protect the public.
Per Dr Atul Gawande, ex USAID: βAll malaria supplies protecting 53 million people, mostly children, including bed nets, diagnostics, preventive drugs, and treatments β terminated.β
There are no words that sufficiently describe this level of cruelty and sadism.
At the Antimicrobial peptides GRC Conference in beautiful Ventura, California. Thanks to Delphine Destoumieux-GarzΓ³n and Gerard Wood for the invitation and the opportunity to talk about Generative AI for antimicrobial peptide discovery! With
@szymczakpau.bsky.social, her poster and amazing sunset:)
Good to see moscot-tools.org published in @nature.com ! We made existing Optimal Transport (OT) applications in single-cell genomics scalable and multimodal, added a novel spatiotemporal trajectory inference method and found exciting new biology in the pancreas! tinyurl.com/33zuwsep
Congrats! Much deserved!
overview of results for PLAID!
1/𧬠Excited to share PLAID, our new approach for co-generating sequence and all-atom protein structures by sampling from the latent space of ESMFold. This requires only sequences during training, which unlocks more data and annotations:
bit.ly/plaid-proteins
π§΅
Next up - contributed talk.
HelixFlow, SE(3)βequivariant Full-atom Design of Peptides With Flow-matching Models
Xuezhi Xie, Pedro A Valiente, Jisun Kim, Jin Sub Lee, Philip Kim
Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! π€―
www.nature.com/articles/s41...
Hi @ddelalamo.bsky.social unfortunately, this paper from Jain et al. contains falsehoods, misleading comparisons, seemingly deliberate omissions, and is written in a tone not intended as a serious research paper. Please see our detailed response: www.linkedin.com/pulse/respon...
Looks like yet another case of overhyped results due to poor #bioMLeval evaluation of deep learning models -this time deep docking methods - specifically DiffDock. Look forward to the DiffDock authors response. But dont see any major flaws in this critique. Conclusion is REALLY worth reading!
Oh wow. Maybe kind of a harsh attack, but we really do need a healthy debate about docking benchmarks. While I'm excited to see this one being fought out, may I already suggest the next point of debate: can we find a better metric than the utterly inadequate 2 Γ RMSD cutoff?
scRNA-seq has revolutionized biology, but itβs not without challenges. We uncovered significant quality issues in widely used reference cell atlases like the Human Cell Atlas and Tabula Sapiens. Up to 85% of cells in some datasets are low-quality or misidentified!
2/8
Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...
I have created a starter pack for the Polish ML community. Let's grow it together! Let me know if you know somebody who should be included.
go.bsky.app/TSkgFjK
Me as well!
Nauka na okΕadce! Polecam jeszcze raz Εwietny tekst @alicjagardulska.bsky.social, ktΓ³rego nie sposΓ³b przeoczyΔ w weekendowej Wyborczej π
Online Now! A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden by Olivia N. Rebeck, Miranda J. Wallace, Jerome Prusa, Gautam Dantas, et al at @WUSTL @MDAndersonNews http://dlvr.it/TGPvW1
Valid point
