Pinki Gahlot

Great story, João! 👏

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...

Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...

Thank you! :)

Excellent thesis defense by Pinki Gahlot concluding brillant work on a sensor module, SPG20-ITCH that detects lipid packing defects in the limiting membrane of permeabilized #lysosomes and initiates #lysophagy.

Lysosomal membrane homeostasis and its importance in physiology and disease Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.

New Online! Lysosomal membrane homeostasis and its importance in physiology and disease

ATXN3-p97 facilitates #lysosomal restoration after damage by deubiquitinating LAMP2 and targeting it for degradation via microautophagy
Hemmo Meyer and coworkers @hemmo-lab.bsky.social
www.embopress.org/doi/full/10....

Timing could be one of the factors. Additionally, I would say that the extent of damage would be a determinant as well in that case.

Thrilled to share our work on the role of Ataxin-3 in lysosome regeneration published in @embojournal.org . Here we show that Atxn3 targets K48-K63 branched ubiquitin chains on damaged lysosomes and mediates restoration of lysosomal function via microautophagy.

www.embopress.org/doi/full/10....