Alessandro Sessa

I have position for research assistant in my Lab at Ospedale San Raffaele in Milan. Please spread the voice and drop me a message if interested

Happy New Year to all! May this year be filled with laughter, love, and all the good things life has to offer (including exciting scientific achievements!)

A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development The SOX2 epigenetic silencer (SES) is a synthetic GBM inhibitor factor that represses the SOX2 oncogenic transcriptional network.

Here the ESF based on SOX2 DNA binding activity www.science.org/doi/10.1126/.... This technology is now the core business of the spin-off company Repron therapeutics (www.reprontherapeutics.com/).5/n

On the other side of the lab, we are developing epigenetic silencer factors which, acting as dominant negative counterpart of oncogenic TFs, induce the death of tumor cells in cell-autonomous fashion. 4/n

SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome - Nature Communications Schinzel-Giedion syndrome (SGS) is a fatal developmental syndrome characterized by severe intellectual and physical deficits due, at least in part, to early neurodegeneration. Here the authors introdu...

See for example our works of Schinzel-Giedion syndrome www.nature.com/articles/s41... and www.nature.com/articles/s41.... 3/n

Regarding the first topic, we are active in creating experimental models useful to both better understand the physiopathology of the diseases and as platform to test new treatments. 2/n

Let’s to introduce myself. I am a developmental neurobiologist by training, currently serving as a group leader at the San Raffaele Scientific Institute in Milan. My research focuses on two main areas: 1) rare disorders and 2) synthetic epigenetic editors for the treatment of tumors.1/n