Stefan O. Bassler

Proud that this work is now published!

We hope it helps orient future #Nanopore long-read sequencing studies hunting for structural variants

Also really happy to share eight new high-coverage (>100x) long-read read pools and assemblies with the #Drosophila community!

doi.org/10.1093/g3jo...

Very proud of this contribution. Beautiful and hyper careful work by @jahemker.bsky.social showing that not all long read assembles are created equal and at times it really does matter to have enough not just long but very long reads. Curious what you all think!

Very proud of this paper, now officially out at PRX LIFE journals.aps.org/prxlife/abst.... Here @mrazo.bsky.social shows that geometry-aware autoencoder architecture can discover low dimensional phenotypic spaces traversed by evolution. 1/2

Integrative Proteomic and Metabolomic Signatures of Accelerated PhenoAge in the UK Biobank Aging is accompanied by molecular changes across multiple biological systems that contribute to functional decline and increased disease risk, but the underlying mechanisms and inter-individual variat...

Excited to share our new preprint on multi-omics signatures of accelerated PhenoAge.

By integrating plasma proteomics and metabolomics, we identified pathways associated with faster aging, including immune-inflammatory activity.

www.medrxiv.org/content/10.6...

Benchmarking EGF signaling pathway inference using phosphoproteomics and kinase-substrate interactions - Nature Communications To what extent can large-scale approaches accurately reconstruct classic signaling pathways? Here, authors revisit the EGF pathway using phosphoproteomics and kinase-substrate interactions

Is the linear map of cell signaling a myth?
New research suggests the reality of cellular networks is more complex.
@savitski-lab.bsky.social & @saezlab.bsky.social combined experimental and computational expertise to test how we map kinase–substrate interactions.
www.nature.com/articles/s41...

Applications for our Next Generation Leaders program are open!

For 3 years, accepted early career scientists will join a supportive network and contribute to our research initiatives.

Apply by Mar. 31: https://bit.ly/3OjzdRa

📸 Photo by NGL Alum @bjmarlin.bsky.social

Link: www.biorxiv.org/content/10.6...

The increased mutation rate of DNA-repair–deficient mutators accelerates resistance evolution in bacteria and cancer. In a great collaboration with @mulkern.bsky.social, we find that DNA-damaging antibiotics can turn this advantage into a liability—but only for certain genotypes.

Text: We seek: Game changers in infection research; Human Microbe Alliance for Universal Health (HUMAN) program; in the background a night sky with a shooting star and an electron micrograph of different bacteria

Are you a game changer in infection research? Apply for a HUMAN junior research group leader position (with professorship and tenure options) at the HZI by March 30!

Infection Biology: jobs.helmholtz-hzi.de/job/Braunsch...

AI in Health and Infection Research: jobs.helmholtz-hzi.de/job/Braunsch...

The next BAPG has been announced! April 11 at Davis organized by the inimitable @jrossibarra.bsky.social! bapg-conference.github.io

EMBL International PhD Programme - summer recruitment 2026! 👀

Research groups across EMBL are recruiting now! www.embl.org/about/info/e...

Don’t miss this opportunity to receive dedicated mentoring while doing interdisciplinary research.

Call for the position as Helmholtz Junior Research Group Leaders at the Helmholtz Institute for RNA-based Infection Research or Helmholtz Institute for Pharmaceutical Research Saarland

Join the HZI as a Junior Research Group Leader at @helmholtz-hiri.bsky.social or @helmholtzhips.bsky.social!
We’re seeking exceptional postdocs for the @helmholtz.de Investigator Groups program. Shape cutting-edge research in infection biology & apply by Feb 15!
jobs.helmholtz-hzi.de/job/Saarbr%C...

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

📢 Prof. Dr. Dmitri Petrov from the School of Humanities and Science | Department of Biology, Stanford University, will give a lecture on “Barcoding Fitness Landscapes of Tumorigenesis” at the @leibnizfli.bsky.social on January 22, 2026.

👉 More information: bit.ly/4pGtqSu

Interview with Prof. Dr. Dmitri Petrov YouTube video by Leibniz-Institut für Alternsforschung - FLI e.V.

➡️ Prof. Dr. Dmitri Petrov from the School of Humanities and Science | Department of Biology, Stanford University, spoke today at the @leibnizfli.bsky.social about “Barcoding Fitness Landscapes of Tumorigenesis”. Before he gave his lecture, we had the opportunity to interview him.

🎤 bit.ly/4r66mxG

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease. Here, ...

Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025

PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized non-ribosomal proteins Building a universal biochemical constructor, an autonomously self-replicating biochemical system, is a major challenge in synthetic biology. The PURE cell-free system is an ideal starting point for e...

Saeed's latest paper is now out on bioRxiv:

"PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized non-ribosomal proteins"

www.biorxiv.org/content/10.6...

Excited to co-organize with @weieli.bsky.social a symposium at SMBE 2026 on how synthetic & systems biology can illuminate the molecular mechanisms of evolution. Honored to have @christianlandry.bsky.social as invited speaker! Join us!

How do new centromeres evolve while staying compatible with the division machinery?

Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.

👉 doi.org/10.1038/s41586-025-09779-1

Super excited that the bulk of my PhD work is now preprinted! Here we used whole-community competition, or coalescence, experiments to quantify selection acting on genetically diverged strains within larger communities. (1/n)
www.biorxiv.org/content/10.1...

For population genetics and evolutionary biology folks in the Bay Area: the next BAPG will be hosted by Stanford CEHG and the Petrov lab at Stanford on 12/6.
Registration is free but required. The deadline for talk submission is Nov. 16. Hope to see you soon! Pls RT!
docs.google.com/forms/d/e/1F...

Job alert🚨📢! Join us as Director of the SIB Centre for Pathogen Bioinformatics, on a topic where global collaboration is particularly important, in a highly stimulating environment. This is a research infrastructure leadership position.

Apply or spread the word!

apply.refline.ch/499599/0346/...

Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...

One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.

www.biorxiv.org/content/10.1...

How nutrient starvation impacts the gut microbiome - Nature Microbiology In this Perspective, Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.

#Perspective

Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.

#MicroSky #MicrobiomeSky 🦠

www.nature.com/articles/s41...

Excited to share our preprint led by Carlos Voogdt et al

We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...

E15 Groups The Helmholtz Institute for RNA-based Infection Researchopens a call for

Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

📣The 2026 ERC Consolidator Grant competition is now open! 📣

Already preparing your proposal? Info links ⬇️

Info for applicants 👉 buff.ly/PSbeUxX

Application portal 👉 buff.ly/mauZoqo

Deadline: 13/01/26

General info on #ERCCoG 👉 buff.ly/KCN6GTh

Graphic with a blue background and light green dots. The text 'call for applications' appears in green, and 'Ausschreibung' in white. A white arrow on the right points diagonally upward.

Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Directors The Max Planck Society offers Directors a unique platform for groundbreaking research and leadership in diverse scientific fields.

Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors