Epigenetic and chromatin mechanisms
Post-transcriptional mechanisms
Translational/post-translational mechanisms
Metabolic rewiring and mitochondrial biology
Their crosstalk and emerging models and technologies to study them
Featuring an exceptional lineup to discuss the complex molecular landscape that contributes to drug resistance, including:
Heading to #ASH25?
Don't miss our Scientific workshop on Mechanisms of Therapy Resistance in Blood Malignancies. Tomorrow, Friday, December 5, 2025, 3:00 p.m. - 6:00 p.m. ET. Room OCCC - W414CD
lnkd.in/ePKx5bg6
@ash.hematology.org
When mitochondria shift, cancer shifts.
Our new review dives into how mitochondrial fusion/fission rewire blood cancer behavior and treatment responses.
New opportunities for targeted therapies, better outcome prediction, & the key knowledge gaps👇
link.springer.com/article/10.1...
Kudos to my first trainees: Sofia, Saurav, and the whole team of the Glytsou Lab.
Huge thanks to my mentors and all our collaborators throughout this journey.
We also thank the editors and reviewers.
Our studies that shed light on developing more effective leukemia therapies would not have been possible without support from the NIH, @bloodcancerunited.bsky.social
, Rutgers Cancer Institute, the V Foundation, and the NJCCR.
Extensive metabolomics, fluxomics & transcriptomics revealed that OPA1 inhibition rewires AML metabolism, rendering AML cells dependent on glutamine, sensitive to glutamine depletion/glutaminase inhibition, & prone to erastin-induced lipid peroxidation/ferroptosis.
Mechanistically, OPA1 inhibitors amplify apoptotic cristae remodeling upon stimulation and sensitize AML models to programmed cell death, independent of the mutational background.
We next leveraged the first-in-class small molecules that inhibit OPA1, developed by the team of Luca Scorrano
pubmed.ncbi.nlm.nih.gov/40614185/ and showed that they synergize with BH3-mimetic drugs to curtail resistance in AML PDXs in vivo, without affecting healthy hematopoietic cells.
Genetic targeting of OPA1 in combination with venetoclax significantly extends animal survival in AML xenograft models.
Using electron microscopy and morphometric analyses in AML cell lines and patient samples, we demonstrate that OPA1-dependent tightening of mitochondrial cristae is a common feature of therapy-resistant AML.
Big news from the #Glytsoulab today!✍️Our research on drug resistance in leukemia is published in
@ScienceAdvances
Targeting OPA1 can help overcome therapy resistance in AML, including the most challenging cases. www.science.org/doi/10.1126/...
📢Interested in #CancerMetabolism and #leukemia using mouse models in vivo? Come join us!! We're looking for a #postdoc to help us drive one of our multiple currently funded projects! Friends & colleagues, please RT!
👇👇👇
jobs.rutgers.edu/postings/260...
Did you know the Scientific Workshops at #ASH25, taking place Friday before the meeting, are included in your meeting registration?
Make connections and share your work!
Learn more about the topics: https://bit.ly/4m8HymN #Hemesky #MedSky
A comprehensive review of the BH3 mimetics transforming the treatment of AML and the ongoing efforts to identify and overcome resistance mechanisms.
Grateful to be part of this collaborative endeavor.
www.nature.com/articles/s41...
We'll cover 4 key areas:
• Epigenetic & chromatin mechanisms
• Post-transcriptional regulation
• Translational/post-translational control
• Metabolism & mitochondrial biology
www.hematology.org/meetings/ann...
Got new insights into therapy resistance mechanisms in heme malignancies? We'd love to hear from you-please reach out to Panos Ntziachristos, Dan Starczynowski, or me to secure a speaker slot and share your findings at the @ash.hematology.org Workshop #ASH25 -Friday, Dec 5, 2025, 3-6pm, Orlando, FL
Marta Romo is representing the #Glytsoulab at the FASEB Heme Malignancy conference this week. Stop by her poster tomorrow to check out her recent research findings 🧪 #HEMSRC events.faseb.org/event/7960e1...
Two compendia to visualize and predict the dynamic nature of mitochondrial complexes during mitochondria remodeling. Check it out:
www.cell.com/cell-metabol...
Started as part of my PhD studies and brought across the finish line by a fantastic team! Very proud and grateful to all the co-authors!
New book chapter published! Electron Microscopy to Visualize and Quantify Mitochondrial Structure and Organellar Interactions in Cultured Cells During Senescence
part of the book Oncogene-induced senescence in Methods in Molecular Biology link.springer.com/protocol/10....
